Abstract: Compounds of formula A-I and B-I, compositions comprising the compounds, methods of making the compounds and methods of their uses are disclosed.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, A, A?, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: Compounds of formula A-I and B-I, compositions comprising the compounds, methods of making the compounds and methods of their uses are disclosed.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.

Abstract: Examples provide a configurable item display dolly. The item display dolly includes a plurality of attachment slots for attaching support arms that hold trays and/or items. In a closed configuration, the support arms are configured to hold the trays a minimum distance apart. In an open configuration, two or more of the support arms are separated a maximum distance apart to enable users to access items on the item display dolly. The item display dolly transports trays of items from a storage area in a transport mode and converts to an item display device in a display mode. A controller component analyzes sensor data, including weight data and temperature data, to update item display dolly inventory, identify broken/damaged items, alert users when trays are empty and/or trigger maintenance or other action if temperature levels fall outside acceptable cold-chain compliance temperature ranges.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.

Abstract: A disclosed system for transporting items to destination locations, for example automatically placing stacked products at selected locations within a large retail facility, includes a conveyor assembly, an item identifier, a robotic arm with a plurality of end effectors, and a sorter component operable to select one of the plurality of end effectors and remove items selected for diversion from the conveyor assembly with the robotic arm. The sorter component stacks the removed items, and the stacked items are transported to a selected location within the retail facility, for example using an autonomous ground vehicle (AGV).

Abstract: A disclosed system for transport asset monitoring, for example monitoring truck trailer unloading progress at large retail locations, includes an artificial intelligence (AI) solution for managing operations at a facility. The AI solution analyzes current load percentage and other data to predict availability for moving the transport asset and ability to accept a new incoming transport asset. Predictions of availability can reduce response times, resulting in higher utilization rates for assets, thereby improving efficiency. An exemplary system includes a sensor configured to sense operation progress parameter data for a transport asset; and logic to receive the operation progress parameter data from the sensor; determine, using the AI solution and based at least on the operation progress parameter data, a predicted milestone parameter; and report the predicted milestone parameter to a remote node.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: A shelving system is provided, which includes a plurality of supports, each support of the plurality of supports having a longitudinal opening defining a channel extending from a first end to a second end of the support, the plurality of supports having at least one opening positioned on a surface of the plurality of supports, at least one shelf, the at least one shelf including an extension, the extension being positioned within the channel of each of the plurality of supports to allow a vertical movement of the at least one shelf with respect to the plurality of supports; and an actuator operably coupled to the at least one shelf, wherein actuation of the actuator permits the vertical movement of the at least one shelf within the channel. Furthermore, an associated method is also provided.

Abstract: Compounds of formula A-I and B-I, compositions comprising the compounds, methods of making the compounds and methods of their uses are disclosed.

Abstract: There is provided systems and methods involving a portable distribution center for distributing merchandise in response to emergencies. The distribution center includes a transport vehicle with a locomotion system for movement of the transport vehicle to an emergency location. It also includes a conveyor system for sortation and distribution of merchandise items upon arrival at the emergency location. The conveyor system includes merchandise identifier for reading identification data from merchandise item; a plurality of sortation units for moving merchandise items to uniquely identified destination lanes; and a control circuit configured to: assign merchandise items to uniquely identified sortation destination lanes; receive identification data; and communicate with the plurality of sortation units. The distribution center also includes a power supply for energizing the conveyor system and a communication system.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: Examples provide a configurable item display dolly. The item display dolly includes a plurality of attachment slots for attaching support arms that hold trays and/or items. In a closed configuration, the support arms are configured to hold the trays a minimum distance apart. In an open configuration, two or more of the support arms are separated a maximum distance apart to enable users to access items on the item display dolly. The item display dolly transports trays of items from a storage area in a transport mode and converts to an item display device in a display mode. A controller component analyzes sensor data, including weight data and temperature data, to update item display dolly inventory, identify broken/damaged items, alert users when trays are empty and/or trigger maintenance or other action if temperature levels fall outside acceptable cold-chain compliance temperature ranges.

Abstract: There is provided systems and methods involving a portable distribution center for distributing merchandise in response to emergencies. The distribution center includes a transport vehicle with a locomotion system for movement of the transport vehicle to an emergency location. It also includes a conveyor system for sortation and distribution of merchandise items upon arrival at the emergency location. The conveyor system includes merchandise identifier for reading identification data from merchandise item; a plurality of sortation units for moving merchandise items to uniquely identified destination lanes; and a control circuit configured to: assign merchandise items to uniquely identified sortation destination lanes; receive identification data; and communicate with the plurality of sortation units. The distribution center also includes a power supply for energizing the conveyor system and a communication system.