Abstract: Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.

Abstract: Methods for improving a therapeutic response and/or preventing adverse events that may occur upon or during treatment with a compound with activity as an aryl hydrocarbon receptor (AhR) agonist are described. An exemplary method comprises, prior to treating a subject with an AhR agonist compound, testing, or instructing to test, a sample from a subject to be treated for a diagnostic marker related to aryl hydrocarbon receptor biology. Based on a result from the testing one or more of (i) administering the AhR agonist compound, (ii) not administering the AhR agonist compound, and (iii) altering a dose or a dosing protocol of the AhR agonist compound is/are performed.

Abstract: Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.

Abstract: A compound having one of the following structures of Formula (IV) or (V): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5 R6, R7, R8, R10, R11a R11b, R12a R12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: A compound having one of the following structures of Formula (IV) or (V): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5 R6, R7, R8, R10, R11a R11b, R12a R12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: A system includes sensors deployed along a vehicle pathway to detect the presence of a plurality of vehicles. An embodiment of a method for detecting speed may include generating from the sensors presence data of each of the plurality of vehicles and transmitting the detected presence data to a base station. The transmitting may include transmitting the detected presence data from the sensors to an access point and transmitting the detected presence data from the access point to the base station. The base station determines a speed of each of the plurality of vehicles. The speed may be determined at a periodic interval responsive to a predetermined distance between the sensors and a difference in the detection time of each of the plurality of vehicles at each of the sensors.

Abstract: A compound having one of the following structures of Formula (IV) or (V): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5 R6, R7, R8, R10, R11a R11b, R12a R12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: Systems and methods for redundant storage among networked video cameras are described. Video data for a group of video cameras is received by a parity video camera. The parity video camera calculates parity across the peer video data, stores the parity data to one storage location and backup video data for the storage location to another storage location. In some examples, the storage locations are selected from among the non-volatile memory of the group of video cameras or another group of video cameras.

Abstract: Systems and methods for redundant storage among networked video cameras are described. Video data for a group of video cameras is received by a parity video camera. The parity video camera calculates parity across the peer video data, stores the parity data to one storage location and backup video data for the storage location to another storage location. In some examples, the storage locations are selected from among the non-volatile memory of the group of video cameras or another group of video cameras.

Abstract: The present invention provides radical crosslinked zwitterionic gels, methods of preparing the radical crosslinked zwitterionic gels, and methods of using the radical crosslinked zwitterionic gels for treating a wound.

Abstract: Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.

Abstract: Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.

Abstract: The present disclosure provides methods for purifying a solution comprising cantharidin and cantharidin-associated impurities. A method to purify the solution can comprise recrystallization or sublimation, for example. The purified cantharidin can be analyzed using a detection method comprising a stationary phase and one or more mobile phases.

Abstract: Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.

Abstract: Provided is a multi-fiber system that undergoes new chemical bonds in response to mechanical manipulation and has self-adhesive properties based on specific chemical reactions.

Abstract: Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.

Abstract: A system includes sensors deployed along a vehicle pathway to detect the presence of a plurality of vehicles. An embodiment of a method for detecting speed may include generating from the sensors presence data of each of the plurality of vehicles and transmitting the detected presence data to a base station. The transmitting may include transmitting the detected presence data from the sensors to an access point and transmitting the detected presence data from the access point to the base station. The base station determines a speed of each of the plurality of vehicles. The speed may be determined at a periodic interval responsive to a predetermined distance between the sensors and a difference in the detection time of each of the plurality of vehicles at each of the sensors.

Abstract: Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.

Abstract: Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.

Abstract: The present disclosure provides methods for synthesizing cantharidin and cantharidin derivatives.