Abstract: According to the invention, a safety device for a pre-filled syringe comprises of a needle shield adapted to cover an injection needle of the pre-filled syringe before and after an injection, a support body with at least one pivoting arm adapted to engage a barrel collar of the pre-filled syringe and an outer body with a first inner sleeve comprising a bevelled section. The needle shield, the support body and the outer body are telescopically arranged. The needle shield, the support body and the outer body may telescope with respect to each other to cover and to expose the injection needle of the pre-filled syringe. The bevelled section is arranged to abut against the pivoting arm connected to the support body by a living hinge to deflect the pivoting arm radially inwards, so that the pivoting arm may engage the barrel collar after a dose of a medicament contained in the pre-filled syringe has been disposed beneath the skin of a patient receiving the injection.

Abstract: The invention relates to a front end for an auto-injector, the front end comprising a syringe with an injection needle and a stopper, wherein the syringe is slidably arranged within a syringe retainer, wherein an outer sleeve for preventing access to the needle is removably arrangeable over the syringe retainer, wherein the syringe retainer comprises a screw thread for connecting it to a correspondent screw thread of a mounting of a re-usable auto-injector back end comprising a drive means for advancing the syringe and needle in a proximal direction for needle insertion and for advancing the stopper within the syringe for injection, wherein a resilient locking barb is arranged to rotationally lock the syringe retainer to the mounting in an unscrewing direction when the front end is screwed to the re-usable back end and when the outer sleeve is removed, wherein the outer sleeve is arranged to unlock the resilient locking barb when arranged over the syringe retainer.

Abstract: The invention relates to a compression connection means for an auto-injector (A), wherein the compression connection means adapted to attach a front-end device of the auto-injector (A) to a back-end device of the auto-injector (A) comprises of an annular mounting sleeve that is axially displaceable parallel to a longitudinal axis (X) between a locked position (L) and an unlocked position, a mounting sleeve spring biasing the mounting sleeve towards a locked position (L), at least one latch arm connected to one of either the front-end device or the back-end device, wherein the latch arm is deflectable in a radial direction, wherein the mounting sleeve in the locked position (L) is arranged to prevent the radial deflection of the latch arm and wherein the mounting sleeve in the unlocked position allows for a radial deflection of the latch arm, so as to allow the latch arm to be deflected on assembly or disassembly of the front-end device to the back-end device and to latch to or unlatch from the other of the fr

Abstract: According to the invention, a safety device for a pre-filled syringe with an injection needle comprises of a support body adapted to mount the pre-filled syringe, a needle shield slidably arranged with respect to the support body, a retention and locking means (M) for retaining and locking the needle shield with respect to the support body in a first and a second advanced position (PA1, PA2) and in a retracted position (PR). The needle shield comprises an annular flange adapted to rest on the skin of the patient receiving an injection. The retention and locking means (M) are arranged at a distal end of the safety device.

Abstract: Auto-injector for delivering a liquid medicament (M), the auto-injector comprising an elongate housing having a loading bay configured to receive a packaged syringe, wherein the loading bay is configured to be laterally accessible for inserting or removing the packaged syringe, wherein a sliding door is slidably arranged over the housing in a manner to reveal the loading bay in a distal position and to cover the loading bay in a proximal position.

Abstract: The invention refers to an engine for an auto-injector for administering a dose of a liquid medicament, the engine comprising a case having a distal end and a proximal end arranged to be attached to a packaged syringe containing a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, wherein the syringe is slidably arranged with respect to the case, the case containing: drive means capable of, upon activation: pushing the needle from a covered position into an exposed position, and operating the syringe to supply the dose of medicament, and activating means arranged to lock the drive means in a loaded state prior to manual operation and capable of, upon manual operation, releasing the drive means for injection, characterized in that the drive means is arranged as a gas spring comprising a cylinder and a piston with a plunger for transmitting the spring force, wherein a compressed gas is provided in a high pressure cavity defined between the piston and a dista

Abstract: The invention refers to an auto-injector for administering a dose of a liquid medicament, comprising: an outer casing, a syringe with a hollow needle and a stopper a torsion spring and a gear arrangement for inserting the needle, delivering the medicament, and retracting the syringe after injection. At least one skin contact trigger element is arranged at a proximal end of the outer case, the skin contact trigger element translatable in longitudinal direction between a proximal position and a distal position and biased in proximal direction in a manner to protrude from the outer casing in the proximal position, wherein in its proximal position the skin contact trigger element is arranged to prevent the spring means from being released and wherein the skin contact trigger element in its distal position is arranged to allow release of the spring means.

Abstract: The invention relates to an auto-injector (A) for administering a dose of a liquid medicament, comprising of a substantially tubular front-end device adapted to contain a syringe with an injection needle and a barrel containing the dose of the medicament and comprising a needle shroud adapted to rest on the skin of a patient receiving an injection and a reusable back-end device comprising of a housing, a plunger connected to or adapted to engage a stopper providing a fluid tight seal for a distal end of the barrel, a motor for displacing the plunger connected to the stopper, wherein the front-end device is attachable to the back-end device, wherein the needle shroud is slidably arranged with respect to the injection needle and wherein an interlock switch is capable of detecting an axial position (PA, PR) of the needle shroud.

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising of an elongate housing arranged to contain a syringe with a hollow needle and a bung for sealing the syringe and displacing the medicament (M), the elongate housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing; spring means capable of, upon activation, pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P) as well as operating the syringe to supply the dose of medicament (M); and activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: The invention relates to a front end for an auto-injector, the front end comprising a syringe with an injection needle and a stopper, further comprising an outer sleeve arranged to be attached to an auto-injector back end comprising a drive means for advancing the syringe and needle in a proximal direction for needle insertion and for advancing the stopper within the syringe for injection, wherein the syringe is slidably arranged within a transfer sleeve which is slidably arranged in the outer sleeve, wherein the transfer sleeve is biased in the proximal direction against the syringe, wherein a locking mechanism is arranged for limiting a proximal extension of the transfer sleeve from the outer sleeve to an initial position in an initial state, wherein the locking mechanism is arranged to allow the transfer sleeve to be extended into a needle safe position covering the advanced needle beyond the initial position after having been translated in the distal direction into a depressed position.

Abstract: The invention refers to an auto-injector comprising: a body, a syringe with a hollow injection needle and a stopper, wherein the syringe is slidably arranged with respect to the body, a torsion spring capable of, upon activation: pushing the needle from a covered position inside the body into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection, wherein the torsion spring is grounded at one end in the body and at the other end in a first gear member rotatable about a longitudinal axis, wherein the first gear member, upon rotation, is arranged for translating a second gear member toward the proximal end (P), the second gear member prevented from rotating and arranged to be coupled to the stopper in order to push it towards the proximal end (P),

Abstract: The invention relates to a front-end device of an auto-injector (A) for administering a dose of a liquid medicament, comprising of a support sleeve with a first screw thread adapted to engage a housing of a back-end device of the auto-injector (A) to attach the front-end device to the back-end device and an outer sleeve mounted onto a support sleeve of the front-end device by a second screw thread, wherein the front-end device is adapted to receive a syringe with an injection needle and a barrel containing the dose of the medicament and wherein the direction of rotation of the first screw thread is opposite to the direction of rotation of the second screw thread.

Abstract: According to the invention, an adaptor means for use in combination with a pre-filled syringe and a safety device for the pre-filled syringe is adapted to affix the pre-filled syringe thereto, whereby the adaptor means engages a barrel of the pre-filled syringe. The adaptor means comprises at least one locking projection that is adapted to lock the adaptor means to the safety device.

Abstract: The invention refers to an auto-injector for administering a dose of a liquid medicament (M), the auto-injector having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising: an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), wherein the syringe (3) is slidably arranged with respect to the housing, a drive means capable of, upon activation: pushing the needle from a retracted position into an advanced position through the orifice and past the proximal end (P), and operating the syringe to supply the dose of medicament (M), a plunger for transmitting power from the drive means to the syringe and/or stopper, activating means arranged to lock the drive means in a compressed state prior to manual operation and capable of, upon manual operation, releasing the drive means for injection, characterized in that translation of the needle and the syringe and/

Abstract: According to the invention, a back-end device of an auto-injector adapted to be attached to a packaged syringe comprises a plunger arranged to abut against a stopper of the packaged syringe to translate an injection needle of the packaged syringe in a proximal direction and to expel a dose of a medicament contained in the packaged syringe through the injection needle, a drive means capable of, upon release, driving the plunger in the proximal direction towards a proximal position, a rotary sleeve with a cam surface adapted to be engaged by a plunger follower formed to the plunger, a torsion spring arranged to exert a torque upon the rotary sleeve and a release element capable of, upon manual actuation, releasing the engagement of the plunger follower with the cam surface. The plunger follower is arranged to engage the cam surface to prevent the rotary sleeve from rotating with respect to the chassis in an initial state.

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe; a syringe retainer slidably arranged with respect to the housing that mounts a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel of the pre-filled syringe; a coupling shroud slidably arranged within the housing and releasably coupled to the plunger; and a single drive means. Upon release, the single drive means is capable of driving the coupling shroud in the proximal direction (P).

Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical chassis arranged to contain a pre-filled syringe with a syringe barrel filled with the medicament (M), an injection needle and a stopper for sealing the syringe barrel, a needle shroud slidably arranged within the chassis and adapted to rest on the skin of a patient receiving an injection, a plunger adapted to translate the stopper to expel the dose of the medicament (M) through the injection needle, a coupling shroud slidably arranged within the chassis and releasably coupled to the plunger and a drive means. Upon release, the drive means is capable of driving the coupling shroud from a first position (I) in a proximal direction (P).

Abstract: An auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel and a drive means releasably coupled to the plunger for advancing the syringe in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means is arranged to be decoupled from the plunger for advancing a needle shroud to a safe position (PS) to surround the injection needle after the injection. According to the invention, the drive means bears against a thrust collar arranged to be releasably coupled to the plunger through a ramped engagement of a first tongue and a first recess so as to rotate the thrust collar on translation in proximal direction (P).

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body having a releasable mounting means adapted to mount a pre-filled syringe within the support body, a hollow outer body sildably arranged with respect to the support body and adapted to receive the support body and a release collar non-rotatably arranged within the support body. The release collar is movable relative to the support body and adapted to release the mounting means. A guide track is formed into at least one substantially planar side wall of the support body. The release collar comprises at least one flexible arm with a guide pin that extends from the flexible arm and protrudes through the guide track. The guide pin is movable within and along the guide track in a plane defined by the substantially planar side wall. A guide rail is formed into at least one substantially planar inner surface of the outer body.