Abstract: Described herein are compounds that inhibit galactokinase (GALK) and other kinases and methods for producing the same. Also described are methods for using Structure-Activity Relationships (SAR) to develop compounds with enhanced activity.

Abstract: The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof: The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

Abstract: The technology relates to providing an enhanced user experience for riders in autonomous vehicles. Two or more displays may be arranged at different locations within a vehicle to provide notifications, alerts and control options. Information may be dynamically and automatically switched between these displays, as well as a rider's own personal communication device(s). What information to present on each screen can depend on factors including how many riders are in the vehicle, their seating within the vehicle, how their attention is focused and/or display location and size. Certain information may be mirrored or otherwise duplicated among multiple screens while other information can be presented asymmetrically on different screens. Presented information may include a “monologue” from the vehicle explaining why a driving action is taken or not taken, alerts about important conditions, buttons to control certain functionality of the vehicle, or other information that may be of interest to the rider.

Abstract: A table apparatus for connection to a toilet bowl. The apparatus includes a clamp for connecting to a toilet-bowl rim. A longitudinally adjustable arm configured to extend from the rim of the toilet to a distal end above the toilet. A table top is attached to the distal end of the adjustable arm for holding common objects such as electronic devices, smart phones, electronic books, magazines, and the like.

Abstract: A ball tracking and scoring system and also enables a game implementation system using this system.

Abstract: A ball tracking and scoring system and also enables a game implementation system using this system.

Abstract: A computer-implemented method of analysing nuclear magnetic resonance, NMR, data of a target object is provided. The method comprises receiving NMR data of the target object, and analysing the received NMR data using a model of the diffusive behaviour of 5 particles within the target object. The model includes a time parameter and a space parameter, the time parameter describing temporal characteristics of the diffusive behaviour of particles in the model and the space parameter describing spatial characteristics of the diffusive behaviour of particles in the model. The model is constrained such that the value of the time parameter and the value of the space parameter 10 are related according to a correlation function. An apparatus for analysing nuclear magnetic resonance, NMR, data of a target object is also provided.

Abstract: The invention relates to a control arrangement for an application “app” for gamblers, the control including a number of steps. The steps included may include a) identification of a potential member through data input into the app b) verification of the identified user identity, c) registration as a member of the identified and verified user; and d) application for a membership level. The control arrangement membership level limits the periodic spend on gambling and the verified member is incentivised by membership rewards and or betting rewards. The invention also relates to variant methods thereon.

Abstract: The technology involves communicating the reachability status associated with an autonomous vehicle to a user such as a rider within the vehicle, a person awaiting pickup, or a customer that scheduled a package deliver. Reachability information about pickup and/or drop off locations is presentable via an app on a user device, which helps set expectations with customers about where the vehicle is most likely to be able to perform a pickup and/or drop off. This may include indicating how much variance there may be based on current congestion, parking or idling regulations, or weather conditions. The reachability information may be presented via one or more visualization tools to indicate the uncertainty and/or likely final location. Presenting such contextual information may be done based on real time information, and the presentation may be updated as needed. Historical information about the location may also be used to lower the level of uncertainty.

Abstract: Aspects of the disclosure relate to providing an end of trip sequence when a vehicle is nearing its destination. One or more computing devices may generate and display a video indicating a projected trajectory of the vehicle and objects detected by sensors on the vehicle, on a map corresponding to a route the vehicle is currently following, where the video is generated from a perspective of a virtual camera at a default position and default pitch A determination that the vehicle has reached a threshold relative to the route of the vehicle may be made and the position and pitch of the virtual camera may be adjusted to an updated position above the vehicle and a perspective which looks downwards towards a roof of the vehicle. The video may then be generated and displayed from the perspective of the virtual camera at the updated position.

Abstract: Aspects of the disclosure relate to providing an end of trip sequence when a vehicle is nearing its destination. One or more computing devices may generate and display a video indicating a projected trajectory of the vehicle and objects detected by sensors on the vehicle, on a map corresponding to a route the vehicle is currently following, where the video is generated from a perspective of a virtual camera at a default position and default pitch A determination that the vehicle has reached a threshold relative to the route of the vehicle may be made and the position and pitch of the virtual camera may be adjusted to an updated position above the vehicle and a perspective which looks downwards towards a roof of the vehicle. The video may then be generated and displayed from the perspective of the virtual camera at the updated position.

Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

Abstract: Disclosed is an anchor for rock or similar material, and methods therefor. The anchor has a hinged base, which base consists of at least a pair of pivotally connected wings, the wings able to pivot about at least one longitudinal axis between, a first position in a closed state and a second position in an open state, the open state having a dimension between opposing parts of each wing that is greater than when in the closed state. A locking mechanism locks the wings in either the first position, or the second position. A connecting portion adapted to enable a load to be connected to the anchor connects to the hinged base, the connecting portion having a loading axis which is substantially parallel to the longitudinal axis. The anchor can be set between either the first position, or the second position, and then anchored to enable a load to be connected thereto.

Abstract: A simulated environment includes a motion control system. The motion control system comprises a suspension structure, a housing slidably engaged to the suspension structure such that the suspension controller translates in a planar manner relative to the suspension structure. A rotary component is rotatably attached to the housing. A plurality of winches are attached to the rotary component, the plurality of winches having cables to allow longitudinal movement of the cables parallel to a force of gravity.

Abstract: Use of co values in smoking cessation are described where an apparatus may be configured to encourage smoking cessation in a user. The apparatus may include a sampling unit which receives a sample breath and determines a level of exhaled carbon monoxide from the sample breath. The sampling unit may be programmed to initiate a first timer for tracking a cumulative time upon a determination that the level of exhaled carbon monoxide is below a predetermined threshold. The sampling unit may also be programmed to initiate a second timer for tracking a countdown time upon a determination that the level of exhaled carbon monoxide is above the predetermined threshold, wherein the countdown time corresponds to a second length of time until the carbon monoxide level within the body of the user is expected to dissipate below the predetermined threshold.

Abstract: The technology includes communicating the current status of a self-driving vehicle to users, such as passengers within the vehicle and other users awaiting pickup. Certain information about the trip and vehicle status is communicated depending on where the passenger is sitting within the vehicle or where the person awaiting pickup is located outside the vehicle. This includes disseminating the “monologue” of a vehicle operating in an autonomous driving mode to a user via an app on the user's device (e.g., mobile phone, tablet or laptop PC, wearable, or other computing device) and/or an in-vehicle user interface. The monologue includes current status information regarding driving decisions and related operations or actions. This alerts the user as to why the vehicle is taking (or not taking) a certain action, which reduces confusion and allows the user to focus on other matters.

Abstract: The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.