Abstract: A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.

Abstract: In one embodiment, a method includes receiving a credit inquiry for a monitored consumer. The method further includes performing at least one credit-inquiry analysis on the credit inquiry. The performing yields at least one of a matched creditor from master creditor records and an inferred credit category based on a lexical analysis. In addition, the method includes, responsive to the performing, determining whether the credit inquiry is related to a previous credit inquiry for the monitored consumer. Further, the method includes, responsive to a determination that the credit inquiry is related to a previous credit inquiry, suppressing a credit alert to the monitored consumer.

Abstract: A method and an automatic layup system for making a stack of a plurality of composite plies are presented. The automatic layup system includes a stacking assembly located in a first plane and a layup tool located in a second plane parallel to the first plane. The stacking assembly and the layup tool are movable towards each other. The method includes the steps of (a) providing one or more composite sheets between the layup tool and the stacking assembly, (b) generating a first composite ply from the one or more composite sheets, (c) placing the first composite ply on the layup tool by the stacking assembly by bringing the stacking assembly and the layup tool close to each other, and (d) repeating the steps (b) and (c) for generating and placing a second composite ply on the first composite ply, which is placed on the layup tool.

Abstract: Disclosed is an anchor for rock or similar material, and methods therefor. The anchor has a hinged base, which base consists of at least a pair of pivotally connected wings, the wings able to pivot about at least one longitudinal axis between, a first position in a closed state and a second position in an open state, the open state having a dimension between opposing parts of each wing that is greater than when in the closed state. A locking mechanism locks the wings in either the first position, or the second position. A connecting portion adapted to enable a load to be connected to the anchor connects to the hinged base, the connecting portion having a loading axis which is substantially parallel to the longitudinal axis. The anchor can be set between either the first position, or the second position, and then anchored to enable a load to be connected thereto.

Abstract: A method includes parsing a text source document to construct a document node tree such that the document node tree includes text offsets indicating the location of the text within the text source document corresponding to each node of the document node tree. The method includes constructing, from the document node tree, a Document Object Model (DOM) and a view node tree that represents the DOM. The constructing of the view node tree includes mapping the view node tree to the document node tree. The method includes providing a running representation of the DOM such that DOM elements of the DOM are linked to the text within the text source document corresponding to the DOM elements via the view node tree and the document node tree.

Abstract: A method includes parsing a text source document to construct a document node tree such that the document node tree includes text offsets indicating the location of the text within the text source document corresponding to each node of the document node tree. The method includes constructing, from the document node tree, a Document Object Model (DOM) and a view node tree that represents the DOM. The constructing of the view node tree includes mapping the view node tree to the document node tree. The method includes providing a running representation of the DOM and one of tracking a modification to the DOM to provide first change information and tracking a modification to the text source document to provide second change information.

Abstract: The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.

Abstract: A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.

Abstract: Aspects of the disclosure relate to providing an end of trip sequence when a vehicle is nearing its destination. One or more computing devices may generate and display a video indicating a projected trajectory of the vehicle and objects detected by sensors on the vehicle, on a map corresponding to a route the vehicle is currently following, where the video is generated from a perspective of a virtual camera at a default position and default pitch A determination that the vehicle has reached a threshold relative to the route of the vehicle may be made and the position and pitch of the virtual camera may be adjusted to an updated position above the vehicle and a perspective which looks downwards towards a roof of the vehicle. The video may then be generated and displayed from the perspective of the virtual camera at the updated position.

Abstract: A multi-purpose munition operates in either a blast mode or a fragmentation mode according to a user input. When operating in the fragmentation mode, a fuze initiates a main explosive fill of the munition which in turn disperses fragments formed from a fragmentation layer of the munition. When operating in a blast mode, prior to initiating the main explosive fill, the fuze initiates a secondary energetic layer which discards the fragmentation layer. The fuze then initiates the main explosive fill thereby producing a blast effect.

Abstract: A method and an automatic layup system for making a stack of a plurality of composite plies are presented. The automatic layup system includes a stacking assembly located in a first plane and a layup tool located in a second plane parallel to the first plane. The stacking assembly and the layup tool are movable towards each other. The method includes the steps of (a) providing one or more composite sheets between the layup tool and the stacking assembly, (b) generating a first composite ply from the one or more composite sheets, (c) placing the first composite ply on the layup tool by the stacking assembly by bringing the stacking assembly and the layup tool close to each other, and (d) repeating the steps (b) and (c) for generating and placing a second composite ply on the first composite ply, which is placed on the layup tool.

Abstract: A control methodology and apparatus for an engine suitable for use in capacitor discharge ignition systems for internal combustion engines or brushless DC motors is provided, which make use of a simple logic block to determine for instance an ignition timing advance angle or duty cycle signal based on actual engine speed versus engine control parameter data stored in a table, which is a read-only memory, preferably configurable. To minimize memory space, a small number of values of engine control parameter versus engine speed are stored in the table and the logic block determines the required engine control signal for a measured value of engine speed by an interpolation process, preferably linear interpolation.

Abstract: An ignition control device having an Electronic Fuel Injection mode and a Capacitive Discharge ignition mode is described. The ignition control device comprises: an output for providing an output voltage, connected or connectable to a load, the load being a fuel injection actuator of an EFI system or an ignition capacitor of a CDI system; and a driver unit connected to the output, for driving the output voltage from a low level to a high level and from the high level to the low level in dependence on an input signal, each transition of the output voltage from the low level to the high level having a low-to-high transition time which is longer for the CDI mode than for the EFI mode.

Abstract: In one embodiment, a method includes receiving a credit inquiry for a monitored consumer. The method further includes performing at least one credit-inquiry analysis on the credit inquiry. The performing yields at least one of a matched creditor from master creditor records and an inferred credit category based on a lexical analysis. In addition, the method includes, responsive to the performing, determining whether the credit inquiry is related to a previous credit inquiry for the monitored consumer. Further, the method includes, responsive to a determination that the credit inquiry is related to a previous credit inquiry, suppressing a credit alert to the monitored consumer.

Abstract: A method of treating ovarian cancer in a subject afflicted therewith comprising administering to the subject an effective amount of an anti-cancer agent and an effective amount of a compound having the structure:

Abstract: In one embodiment, a method includes receiving a credit inquiry for a monitored consumer. The method further includes performing at least one credit-inquiry analysis on the credit inquiry. The performing yields at least one of a matched creditor from master creditor records and an inferred credit category based on a lexical analysis. In addition, the method includes, responsive to the performing, determining whether the credit inquiry is related to a previous credit inquiry for the monitored consumer. Further, the method includes, responsive to a determination that the credit inquiry is related to a previous credit inquiry, suppressing a credit alert to the monitored consumer.

Abstract: A control methodology and apparatus for an engine suitable for use in capacitor discharge ignition systems for internal combustion engines or brushless DC motors is provided, which make use of a simple logic block to determine for instance an ignition timing advance angle or duty cycle signal based on actual engine speed versus engine control parameter data stored in a table, which is a read-only memory, preferably configurable. To minimise memory space, a small number of values of engine control parameter versus engine speed are stored in the table and the logic block determines the required engine control signal for a measured value of engine speed by an interpolation process, preferably linear interpolation.

Abstract: An ignition control device having an Electronic Fuel Injection mode and a Capacitive Discharge ignition mode is described. The ignition control device comprises: an output for providing an output voltage, connected or connectable to a load, the load being a fuel injection actuator of an EFI system or an ignition capacitor of a CDI system; and a driver unit connected to the output, for driving the output voltage from a low level a high level and from the high level to the low level in dependence on an input signal, each transition of the output voltage from the low level to the high level having a low-to-high transition time which is longer for the CDI mode than for the EFI mode.

Abstract: The invention relates to an internal combustion engine (1) with a crankcase (3) and a cylinder head (4) having exhaust ports (9) feeding into an exhaust manifold (10) for exhaust gas from the combustion chambers (5) of the internal combustion engine (1). Provision is hereby made for the cylinder head (4) to include at least one region of a heating channel (12) which is different from the exhaust ports (9) and the exhaust manifold (10) and has an inlet side (14) branching from one of the exhaust ports (9) or the exhaust manifold (10), and which is flowed through by an exhaust mass flow that is adjustable by an actuator (13). The invention further relates to a method for operating an internal combustion engine (1).

Abstract: In one embodiment, a method includes receiving a credit inquiry for a monitored consumer. The method further includes performing at least one credit-inquiry analysis on the credit inquiry. The performing yields at least one of a matched creditor from master creditor records and an inferred credit category based on a lexical analysis. In addition, the method includes, responsive to the performing, determining whether the credit inquiry is related to a previous credit inquiry for the monitored consumer. Further, the method includes, responsive to a determination that the credit inquiry is related to a previous credit inquiry, suppressing a credit alert to the monitored consumer.