Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: Systems and methods for an intelligent inventory system are disclosed. The systems and methods described herein may receive data from a point-of-sale (POS) device of a merchant indicating an item to add to an inventory catalog of the merchant. A rate may be determined that is associated with how many times the item may be returned or exchanged with a similarly-situated merchant. Additionally, or alternatively, the rate may comprise a fluctuation in price for the item and/or an amount of times the item may be re-stocked and/or re-ordered by the similarly-situated merchant. If the determined rate exceeds a threshold rate, a suggestion may be sent to the POS device of the merchant. The suggestion may comprise a suggested second item rather than the item requested, a suggested price to charge for the item suggested, and/or a suggested quantity to order of the item requested.

Abstract: A coulter assembly for collecting soil samples from an agricultural field in one embodiment comprises an annular collection blade configured for penetrating soil to capture a sample, an annular cam ring configured for stationary mounting to a frame of an agricultural vehicle and comprising a cam track, a blade hub coupled to the blade for rotatably supporting the annular collection blade from the annular cam ring, and a movable sample collector mounted to the annular collection blade. The moveable sample collector is configured and operable for extracting a soil sample as the annular collection blade is rotated through the soil. The moveable sample collector in one embodiment comprises a piston mechanism including a cylinder and rod movably disposed therein which actuated by the annular cam ring to alternatingly open and close a collection end of the cylinder as the annular collection blade rotates through the soil.

Abstract: A coulter assembly for collecting soil samples from an agricultural field in one embodiment comprises an annular collection blade configured for penetrating soil to capture a sample, an annular cam ring configured for stationary mounting to a frame of an agricultural vehicle and comprising a cam track, a blade hub coupled to the blade for rotatably supporting the annular collection blade from the annular cam ring, and a movable sample collector mounted to the annular collection blade. The moveable sample collector is configured and operable for extracting a soil sample as the annular collection blade is rotated through the soil. The moveable sample collector in one embodiment comprises a piston mechanism including a cylinder and rod movably disposed therein which actuated by the annular cam ring to alternatingly open and close a collection end of the cylinder as the annular collection blade rotates through the soil.

Abstract: The present disclosure relates generally to roofing products, for example, shingles suitable for covering and protecting the roofs of houses, buildings, and other structures. The present disclosure relates more particularly to a roofing shingle including an upper edge, a lower edge, a first end, a second end, a headlap section, and an exposed section. A nail zone extends across the roofing shingle from the first end to the second end within the headlap section. The roofing shingle includes a top shingle layer including a top surface and a bottom surface. A reinforcement strip is secured to the bottom surface of the top shingle layer and overlaps with the nail zone. Further, a self-sealing material is disposed within the nail zone and is configured to form a seal around a mechanical fastener that punctures the roofing shingle in order to secure the roofing shingle to an underlying roof structure.

Abstract: A system that includes a fuel dispenser terminal and a remote controller. The fuel dispenser terminal is configured to send a service request for a fuel purchase to the remote controller and receive a personalized offer in response to sending the service request. The fuel dispenser terminal is further configured to display the personalized offer, receive a user response indicating the personalized offer was accepted, and send the user response to the remote controller. The fuel dispenser terminal is further configured to receive an authorization token for retrieving the personalized offer and output the authorization token to the customer. The remote controller is configured to update the service request by adding a purchase associated with the personized offer to the fuel purchase, send an encrypted service request to a service processor, generate the authorization token, and send the authorization token to the fuel dispenser terminal.

Abstract: A system includes a longitudinal rack storing a plurality of packs of cigarettes, a shoe movably attached to the rack, a magnet coupled to the shoe and a longitudinal circuit board arranged along the length of the rack. The circuit board includes an array of sensors along the length of the rack, wherein spacing between each pair of sensors equals a thickness of a pack stored in the rack. Each sensor generates a voltage value depending on a position of the magnet in relation to the sensor. The circuit board further includes a memory storing voltage values generated by the sensors, and a processor configured to monitor voltage values generated by the sensors, detect that a particular sensor has generated a maximum voltage value and determine a number of packs stored in the rack based on a particular number of packs corresponding to the particular sensor.

Abstract: A system includes a longitudinal rack storing a plurality of packs of cigarettes, a shoe movably attached to the rack, a magnet coupled to the shoe and a longitudinal circuit board arranged along the length of the rack. The circuit board includes an array of sensors along the length of the rack, wherein spacing between each pair of sensors equals a pre-selected thickness. Each sensor generates a value depending on a position of the magnet in relation to the sensor. The circuit board further includes a memory storing values generated by the sensors, and a processor configured to determine a position of the shoe/magnet based on the values and determine a pack count of the packs based on the position of the shoe/magnet.

Abstract: A service provider that provides a plurality of merchant services can obtain first merchant information associated with a plurality of merchants registered with the service provider. The service provider can obtain intent data associated with the merchants indicating merchant service(s) that individual merchants of the plurality of merchants use or indicated interest in using during onboarding with the service provider. A machine learning model can be trained using the first merchant information and the intent data. The service provider can receive an indication that a potential merchant has initiated an onboarding process with the service provider. The service provider can determine second merchant information associated with the potential merchant and, based at least in part on the second merchant information and the machine learning model, can determine merchant service(s) of the service provider that the potential merchant is predicted to intend to use.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An exercise machine reversible resistance system for reversing the directional force of resistance against an exercise implement before, during, or after the performance of a routine of one or more exercises. The exercise machine reversible resistance system generally includes a frame, an elongated member movably positioned upon the frame, wherein the elongated member has a first run and a second run, a resistance device that applies a resistance force to the elongated member in a single direction, an exercise implement movably connected to the frame and a clutch connected to the exercise implement. The clutch is adapted to selectively engage the first run or the second run of the elongated member for selective control of the resistance direction of the exercise implement.

Abstract: Provided are methods and apparatus for crushing clay, transporting clay, and processing clay. In examples, provided are movable truss conveyor support apparatuses, movable crusher picker apparatuses, picker shaft rakes to clean picker shafts, adjustable hoppers, and tracked crushers. In an example, provided is a crusher including (i) a crusher frame, (ii) a crusher subframe movably suspended from the crusher frame, (ii) a rotary bearing fastened to the crusher subframe, (iv) a rotatable picker shaft rotatably supported by the rotary bearing and adapted to rotate relative to the crusher subframe, and (v) at least one picker fastened to the rotatable picker shaft.

Abstract: A coulter assembly for collecting soil samples from an agricultural field in one embodiment comprises an annular collection blade configured for penetrating soil to capture a sample, an annular cam ring configured for stationary mounting to a frame of an agricultural vehicle and comprising a cam track, a blade hub coupled to the blade for rotatably supporting the annular collection blade from the annular cam ring, and a movable sample collector mounted to the annular collection blade. The moveable sample collector is configured and operable for extracting a soil sample as the annular collection blade is rotated through the soil. The moveable sample collector in one embodiment comprises a piston mechanism including a cylinder and rod movably disposed therein which actuated by the annular cam ring to alternatingly open and close a collection end of the cylinder as the annular collection blade rotates through the soil.

Abstract: Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra?, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Abstract: A passive NOx absorber for treating an exhaust gas from a diesel engine is described. The passive NOx absorber comprises a first washcoat region comprising a zeolite catalyst, the zeolite catalyst comprising a noble metal and a zeolite having a SAR of 2-15.

Abstract: Techniques described herein are directed to intelligently identifying items for resale based on digital records of past purchases. A computing system of a payment processing service can analyze digital record(s) of a user that are representative of previous purchase(s) of the user. Based at least partly on analyzing the digital record(s), an item previously purchased by the user can be identified as a candidate for resale to another user. The computing system can monitor marketplace(s), and can determine, based at least partly on monitoring the marketplace(s), item information for the item. The computing system can create, based at least partly on the item information, a listing for an ecommerce channel that enables the user to sell the item. The listing can include an actuation mechanism that enables the other user to purchase the item, a transaction for which can be processed by the payment processing service.

Abstract: Provisioning multiple artificial reality devices can be accomplished through network communications between a device distributor, an administration system, a provisioning device, and the artificial reality devices. The device distributor can provide, to the administration system, a list of artificial reality devices corresponding to a particular organization. A provisioning device can sign into an account on the administration system and receive the list. The provisioning device can then scan for wireless connectivity with the listed artificial reality devices and can make a wireless connection with any artificial reality devices that respond and that are on the list. The provisioning device can then send these devices credentials for a local WiFi network. The artificial reality devices can automatically, upon receipt of the credentials, connect to the administration system to obtain the software update and/or the configuration data.

Abstract: The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An energy optimized imaging system that includes a light source that has the ability to illuminate specific pixels in a scene, and a sensor that has the ability to capture light with specific pixels of its sensor matrix, temporally synchronized such that the sensor captures light only when the light source is illuminating pixels in the scene.