Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for adjusting an aquaculture camera mounting system. A current combined field of view of two or more cameras that are mounted on an adjustable camera mounting structure in an environment can be determined based upon a current configuration of the adjustable camera mounting structure. A target field of view for the two or more cameras that are mounted on the adjustable camera mounting structure can be determined. Based at least on the field of view target and the current combined field of view, an adjustment parameter for the adjustable camera mounting structure can be determined. The adjustable camera mounting structure can be adjusted according to the adjustment parameter to provide a field of view in accordance with the field of view target.

Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides a heating member that can be formed of a heating element conformed to a heater substrate configured as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size. In some embodiments, the disclosure provides methods of forming an aerosol delivery device, which can include providing a shell, providing a heating member formed of a heating element conformed to a substrate, configuring the heating member as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size, and inserting the heating member within the shell.

Abstract: A method to provide feedback, coaching, and ECG analysis during a cardiac event. A rescuer would typically be attempting cardiopulmonary resuscitation (CPR) and/or administering an electrical shock from a defibrillator and/or collecting electrocardiogram (ECG) data. The method includes a step of providing a data-generation device (e.g., a camera) and computing components. The computer is used to calculate distances on the fly using data generated by the data-generation device, such as a camera, that may be in motion. The method uses the computer to calculate movement of the chest of a patient and to assess outcomes. When CPR contaminates an ECG, the computer removes the unwanted contamination so that proper guidance to the rescuer can be delivered during CPR.

Abstract: A system-directed robotic cart picking system is described. In an example implementation, the system may generate a picking itinerary including pick-to-cart routing based on locations of items in an order fulfillment center and received order data identifying the items, and may transport the carts in the order fulfillment center according to the pick-to-cart routing. The system may determine a zone of the order fulfillment center to which to assign a picker based on the picking itinerary and may determine tasks, such as picking at least one item from the locations to the carts, for the picker located in the zone. In some instances, the system may output pick instructions to a picker client device directing the picker to perform the tasks and may transport the carts to a defined point in the order fulfillment center in response to completion of the tasks.

Abstract: A surgical robotic system includes at least one eye tracking system positioned detect the direction of at least one user's gaze. Input derived from the eye tracking system may be used to enter commands to the surgical robotic system depending on the directions of the gaze detected or other aspects of the gaze such as pupil dilation or speed of eye movement.

Abstract: A data communication apparatus comprising: a plurality of data communication devices comprising a sensor operable to output contextual data associated with a wearer, a plurality of haptic energy generators operable to output a haptic energy toward skin of the wearer, and a control system operable to maintain a data feedback loop with the wearer by causing the plurality of haptic energy generators to output the haptic energy responsive to one of the contextual data and an external data source in data communication with the control system; an electrical network operable to transmit data and power between the plurality of data communication devices; and a wearable structure comprising a biocompatible material shaped to house the plurality of data communication devices and the electrical network, maintain a plurality of air gaps between the plurality of data communication devices, and define a skin contacting surface that is directly engageable with the skin.

Abstract: Exemplary aspects of a treatment device are described, such as a body, a plurality of generator elements, and a housing. The body may contain a processing unit. The plurality of generator elements may be disposed within the body and be independently operable to output different energy types. The housing may be removably securable to the body. The housing may have a proximal end, a distal end, and a circumferential wall surrounding the plurality of generator elements when the housing is secured to the body, the distal end of the housing being positionable on skin about an area of the skin. The housing also may include an insulating material for permitting flows of the different energy types toward the area of skin and limiting flows of the different energy types outside the housing. Related apparatus, methods, and systems are described.

Abstract: Embodiments described herein are directed to an annotation system having a remote processor, and a client processor in data communication with the remote processor. The client processor is adapted to send a first request for an electronic file to the remote processor, receive the electronic file from the remote processor, define at least one new annotation about the electronic file, and define at least one anchor associated with the at least one annotation. The at least one of the remote processor and the client processor is adapted to store the at least one anchor and the at least one annotation in an annotation file that is separate from the electronic file.

Abstract: A user makes a request from a requesting device for access to a secure operation associated with a network-based service. A first biometric authentication is processed for the request and at least one second scope-based authentication is processed for the request based on an analysis of a physical environment for the requesting device. A determination is made based on at least the first biometric authentication and the scope-based authentication whether the secure operation can be: processed on behalf of the user by the network-based service, not processed at all, or processed only if requested from a specific medium/channel associated with a specific device, which may or may not be the requesting device.

Abstract: A consumer is identified at a transaction terminal. A natural-language voice chatbot is initiated for the transaction. The chatbot is configured with store information for a store associated with the terminal and, optionally, with preferences registered to the consumer. A natural language voice dialogue using, at least the store information, is initiated between the chatbot and the consumer while the consumer is at the terminal and during the transaction. The consumer may order store items from the store and pay for the items through the dialogue. In an embodiment, the items ordered are delivered to the terminal where the consumer is located.

Abstract: A valve repair devices and systems for repairing a native valve of a patient include a spacer, a plurality of paddles, and a plurality of moveable clasp arms. The plurality of moveable clasp arms are disposed between the plurality of paddles and the spacer. The moveable clasp arms are configured to attach to leaflets of a heart valve.

Abstract: In a method for applying penalties or incentives to a driver of a rented vehicle, an indication that the driver has agreed to terms for renting the vehicle from the vehicle owner is received, with the terms including the potential application of penalties or incentives to the driver based on driving behavior. Telematics data, indicative of operation of the rented vehicle by the driver during a period of time, is received. By analyzing the telematics data, one or more driving behaviors of the driver during the time period is/are identified. For each driving behavior, a corresponding state of an environment of the rented vehicle when the driving behavior occurred is determined. One or more penalties or incentives are caused to be applied to the driver, based on the driving behavior(s) and the corresponding state(s) of the environment of the rented vehicle.

Abstract: A ball striking device, such as an iron-type golf club head, includes a face having a ball striking surface and a body connected to the face. The body has a sole surface extending rearward from a leading edge of the face, and a toe surface extending rearward from a toe edge of the face. The sole surface configured to confront the playing surface. The iron-type club head may have an elongated channel extending from a heel side in the sole member to an end point within the toe surface. The elongated channel is recessed from the sole surface and toe surfaces and is spaced from the leading and toe edges of the face. The iron-type club head may also have a plurality of weighting elements that are adjustable by the user.

Abstract: The invention provides a neck-worn sensor (referred to herein as the ‘necklace’) that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure. And from pulse pressure and pulse transit time, a second algorithm, also employing a linear algorithm, can estimate systolic blood pressure and diastolic blood pressure. Thus, the necklace can measure all five vital signs along with hemodynamic parameters. It also includes a motion-detecting accelerometer, from which it can determine motion-related parameters such as posture, degree of motion, activity level, respiratory-induced heaving of the chest, and falls.

Abstract: A method for controlling a dual fuel engine system includes determining a friction power loss amount of an internal combustion engine of the dual fuel engine system, where the friction power loss amount is based on an engine speed of the internal combustion engine and a friction torque estimate. The method also includes determining an accessory power loss amount of a power of the internal combustion engine, where the accessory power loss amount is based on the engine speed and an accessory torque estimate. The method further includes estimating a net engine power amount based on the accessory power loss amount and a brake power amount of the internal combustion engine, estimating an indicated diesel power, and estimating, based on the estimated net engine power, a first indicated engine power and a first gas power.