Abstract: An actuator for aviation applications, in particular for adjusting rotor blades in a helicopter, may include an electromechanical drive assembly connected to an output drive via a downstream transmission, where the drive assembly is divided into sub-drives that can be operated independently, and where at least two sub-drives are spatially separated from one another in that the transmission is placed between these sub-drives. The transmission may include at least two harmonic gearings coupled to one another by at least one first coupling element, where a first harmonic gearing is located inside a non-rotating first housing, where a second harmonic gearing is located inside a rotating second housing, and where the second housing is connected to the output drive.

Abstract: A generator for a wind power installation for generating electrical energy from kinetic energy comprises an outer peripheral surface portion, the outer peripheral surface portion having: an incident-flow surface portion against which wind flows in an incident-flow direction in the installed state of the generator, the incident-flow surface portion extending along an axial direction and orthogonally thereto along a peripheral direction, and a cooling surface portion, designed for cooling the generator and disposed downstream of the incident-flow surface portion in the installed state in the incident-flow direction, the cooling surface portion extending along an axial direction and orthogonally thereto along a peripheral direction, wherein one or more vortex generators for passive cooling of the generator are arranged in a region of the outer peripheral surface portion, in particular in a region of the incident-flow surface portion and/or in a region of the cooling surface portion.

Abstract: A wind turbine comprising a tower, a nacelle arranged on the tower, a generator, and a rotor comprising at least one rotor blade, wherein the wind turbine comprises vortex generators arranged on an outer surface of the tower, wherein the vortex generators have a fin extending from the outer surface of the tower, and wherein the fin has a height extending perpendicularly from the surface of the tower and a fin chord extending parallel to the surface of the tower. The fin chord has a curvature such that a first end of the fin chord has a smaller angle to the horizontal than the opposite second end of the fin chord.

Abstract: Described herein are methods for identifying mitochondrial defects using metabolomics and genetic analyses and using this information to stratify patients and to correct for metabolic defects in a precision medicine approach. One embodiment is a method for isolating and analyzing samples containing one or more mitochondrial biomarker metabolites or genetic markers useful for the analysis, identification, stratification or classification, and treatment of metabolic changes associated with a CNS or neuropsychiatric disease in a subject and therapies useful for the treatment thereof. In one aspect, the biomarker metabolites comprise mitochondrial metabolites including acylcarnitines and endocannabinoids and the genetic analyses focus on metabolic enzymes or transport mechanisms.

Abstract: The invention relates to a single-use connection device for insertion into a connection opening of a bioreactor, in particular in a connection opening of a top plate of a dimensionally-stable bioreactor or in a connection opening of a connection element of a pouch bioreactor. The single-use connection device is inserted in a connection opening of a top plate of a bioreactor and/or in a connection opening of a pouch reactor and is provided with multiple passages and an attachment section, wherein the single-use connection device is formed as a single piece and is made of plastic. The attachment section, on an outer peripheral surface, has an attachment structure for attaching the single-use connection device in the connection opening.

Abstract: A method for ascertaining a wind direction at a wind power installation having a rotor on which at least one rotor blade is arranged. The method includes measuring first wind speeds in a predefined first measuring direction and second wind speeds in a predefined second measuring direction different from the first measuring direction in each case with a measuring frequency at a measuring point for a measuring period, wherein the measuring period is defined by a rotational distance of the rotor or by a prespecified time, wherein the rotor blade or one of the rotor blades passes the measuring point in the measuring period, and determining a wind direction by vectorial evaluation of the first wind speeds and of the second wind speeds.

Abstract: Described herein are methods for stratifying Alzheimer's disease among male and female subjects by analyzing biomarker metabolites. In one aspect, the biomarker metabolite comprises one or more of PC ae C44:4, PC ac C44:5, or PA ae C44:6; or PC ac C44:4, PC ac C44:5, PC aa C32:1, PC aa C32:0, or PC ae C42:4.

Abstract: A device for customizing a washing program for removing soiling from items being washed in a water-conducting household appliance includes a sensor configured to acquire spectral measurement values of organic compounds in washing water in the water-conducting household appliance. A determination unit determines functional groups of the organic compounds based on the acquired spectral measurement values of the organic compounds, and a customization unit customizes washing parameters of a current washing program based on the determined functional groups.

Abstract: Embodiments of the present disclosure relate generally to the analysis and identification of global metabolic changes in Alzheimer's disease (AD). More particularly, the present disclosure provides materials and methods relating to the use of metabolomics as a biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance. Defining metabolic changes during AD disease trajectory and their relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery.

Abstract: Embodiments of the present disclosure relate generally to the analysis of broad metabolic changes associated with neurological disorders. In particular, the present disclosure provides materials and methods relating to the use of metabolomics as a biochemical approach to identify peripheral metabolic changes and corresponding metabolic biomarkers of neurological disorders. Embodiments of the present disclosure include the use of bile acids and their derivatives as metabolic biomarkers to aid in the determination of whether a subject suffers from, or is at risk of developing, a neurological disorder, such as Alzheimer's Disease (AD).

Abstract: A device for customizing a washing program for removing soiling from items being washed in a water-conducting household appliance includes a sensor configured to acquire spectral measurement values of organic compounds in washing water in the water-conducting household appliance. A determination unit determines functional groups of the organic compounds based on the acquired spectral measurement values of the organic compounds, and a customization unit customizes washing parameters of a current washing program based on the determined functional groups.

Abstract: The disclosure relates in particular to a method for ascertaining a wind direction at a wind power installation having a rotor on which at least one rotor blade is arranged, comprising the steps of: measuring first wind speeds in a predefined first measuring direction and second wind speeds in a predefined second measuring direction different from the first measuring direction in each case with a measuring frequency at a measuring point for a measuring period, wherein the measuring period is defined by a rotational distance of the rotor or by a prespecified time, wherein the rotor blade or one of the rotor blades passes the measuring point in the measuring period, and determining a wind direction by vectorial evaluation of the first wind speeds and of the second wind speeds.

Abstract: An integrated circuit is provided with a bandgap voltage reference circuit having a bandgap reference voltage output. A bandgap failure detection circuit is coupled to the bandgap reference voltage output. The bandgap failure detection forms a model value of the reference voltage from a first time, compares a present value of the reference voltage at a second time to the model value; and asserts a bandgap fail signal to indicate when the present value is less than the model value by a threshold value. The integrated circuit is reset by the bandgap fail signal. The detection circuit may be operated from a failsafe voltage domain that also allows a critical circuit to complete a pending operation during a reset.

Abstract: A method for controlling electrical power consumption for a first group of functional which can be used for operational management during operation of the bioreactor components during operation comprises, inter alia, adjusting a present power control signal for one or more of the functional components from the first group in order to optimise power consumption, when a comparison shows for the first group of functional components that the currently required total electrical power consumption is greater than a predefined total electrical power consumption, such that, for the first group of functional components, an adjusted total electrical power consumption is not greater than the predefined total electrical power consumption. A biotechnological apparatus comprises a bioreactor, a reactor vessel formed in the bioreactor and having a cultivation chamber, and a temperature control device provided with a heat pump and configured to control the temperature of the cultivation chamber.

Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.

Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.

Abstract: Object recognition and classification based on data from multiple sensor modalities is disclosed. A computing system can detect an event in a monitored portion of an environment coordinate field associated with a vehicle. The computing system can retrieve data associated with the detected event from a plurality of modalities. At least one of the modalities can include raw data from a sensor associated with the vehicle. The computing system can classify the detected event based at least in part on the retrieved data and one or more parameters of a classifier.

Abstract: The present disclosure relates to compositions and methods for use in the analysis of broad metabolic changes associated with neurological disorders. In particular, the present disclosure provides materials and methods relating to the use of metabolomics as a biochemical approach to identify sex-specific metabolic biomarkers of neurological disorders. Embodiments of the present disclosure include the use of sex-specific metabolic biomarkers to aid in the determination of whether a subject suffers from, or is at risk of developing, a neurological disorder, such as Alzheimer's disease (AD).

Abstract: This patent document relates to the field of biotechnological apparatuses. It relates particularly to a biotechnological apparatus comprising a bioreactor, an exhaust gas temperature control device and a method for treating an exhaust gas stream. This patent document further relates to a connection device for a sterile single-use fluid conduit of a single-use bioreactor and to a method for treating a fluid stream. The reusable connection device comprises a receptacle in which a portion of the fluid conduit can be detachably arranged, and a coupling member connecting the connection device to a temperature control device, the receptacle having a contact surface which is arranged such that the contact surface abuts a fluid conduit arranged in the receptacle, and wherein a portion of a fluid conduit can be introduced into the receptacle in a direction running substantially orthogonally to a longitudinal axis of the connection device.

Abstract: Systems, methods, and computer-readable storage mediums which use annotated environmental models for sensor modification are disclosed. A computing system receives an environmental model for a vehicle. The environmental model can include data from a plurality of modalities. Object annotations are received from sensors which are used to modify the environmental model, creating an annotated environmental model. A classification of a current situation is generated using the annotated environmental model, and a sensor is modified using the classification.