Abstract: An integrated circuit is provided with a bandgap voltage reference circuit having a bandgap reference voltage output. A bandgap failure detection circuit is coupled to the bandgap reference voltage output. The bandgap failure detection forms a model value of the reference voltage from a first time, compares a present value of the reference voltage at a second time to the model value; and asserts a bandgap fail signal to indicate when the present value is less than the model value by a threshold value. The integrated circuit is reset by the bandgap fail signal. The detection circuit may be operated from a failsafe voltage domain that also allows a critical circuit to complete a pending operation during a reset.

Abstract: An integrated circuit is provided with a bandgap voltage reference circuit having a bandgap reference voltage output. A bandgap failure detection circuit is coupled to the bandgap reference voltage output. The bandgap failure detection forms a model value of the reference voltage from a first time, compares a present value of the reference voltage at a second time to the model value; and asserts a bandgap fail signal to indicate when the present value is less than the model value by a threshold value. The integrated circuit is reset by the bandgap fail signal. The detection circuit may be operated from a failsafe voltage domain that also allows a critical circuit to complete a pending operation during a reset.

Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.

Abstract: A proportional to absolute temperature (PTAT) generator, for example, generates a PTAT current (IPTAT) and a VBE (voltage base-to-emitter) in a first regulation loop. A voltage-to-current converter is operable to generate a complementary to absolute temperature current (ICTAT). The IPTAT and ICTAT are summed to obtain a zero temperature coefficient current (IZTC). One ICTAT and one resistor are used to generate the IZTC signal.

Abstract: The invention relates to a single-use connection device for insertion into a connection opening of a bioreactor, in particular in a connection opening of a top plate of a dimensionally-stable bioreactor or in a connection opening of a connection element of a pouch bioreactor. The single-use connection device is inserted in a connection opening of a top plate of a bioreactor and/or in a connection opening of a pouch reactor and is provided with multiple passages and an attachment section, wherein the single-use connection device is formed as a single piece and is made of plastic. The attachment section, on an outer peripheral surface, has an attachment structure for attaching the single-use connection device in the connection opening.

Abstract: A single-use bioreactor, suitable in particular for use in a parallel bioreactor system for applications in cell culture and/or microbiology, a head plate for such a single-use bioreactor and a process for manufacturing the single-use bioreactor and the head plate. The single-use bioreactor comprises a head plate, a dimensionally stable container and a mixer, the head plate and the container enclosing a reaction chamber, and the mixer having a mixer shaft and a stirring member, said mixer shaft being mounted rotatably about a rotational axis in a bearing and the stirring member being fastened torsionally rigidly to the mixer shaft. The mixer and the bearing are arranged entirely within the reaction chamber and the mixer shaft has a magnetic portion which is arranged and adapted in such a way that it can be coupled magnetically in an axial direction to a rotary drive.

Abstract: Object recognition and classification based on data from multiple sensor modalities is disclosed. A computing system can detect an event in a monitored portion of an environment coordinate field associated with a vehicle. The computing system can retrieve data associated with the detected event from a plurality of modalities. At least one of the modalities can include raw data from a sensor associated with the vehicle. The computing system can classify the detected event based at least in part on the retrieved data and one or more parameters of a classifier.

Abstract: Determining a situational annotation of a vehicle based on an annotated environmental model is disclosed. A computing system receives an annotated environmental model for a vehicle. The annotated environmental model can include data from a plurality of modalities. The computing system uses a classifier to determine an annotation of the vehicle situation based, at least in part, on the annotated environmental model. The computing system provides the situational annotation to a driving functionality system. The driving functionality system is configured to use the situational annotation to generate signals to control operation the vehicle.

Abstract: A method for controlling electrical power consumption for a first group of functional which can be used for operational management during operation of the bioreactor components during operation comprises, inter alia, adjusting a present power control signal for one or more of the functional components from the first group in order to optimise power consumption, when a comparison shows for the first group of functional components that the currently required total electrical power consumption is greater than a predefined total electrical power consumption, such that, for the first group of functional components, an adjusted total electrical power consumption is not greater than the predefined total electrical power consumption. A biotechnological apparatus comprises a bioreactor, a reactor vessel formed in the bioreactor and having a cultivation chamber, and a temperature control device provided with a heat pump and configured to control the temperature of the cultivation chamber.

Abstract: A method for controlling electrical power consumption for a first group of functional which can be used for operational management during operation of the bioreactor components during operation comprises, inter alia, adjusting a present power control signal for one or more of the functional components from the first group in order to optimize power consumption, when a comparison shows for the first group of functional components that the currently required total electrical power consumption is greater than a predefined total electrical power consumption, such that, for the first group of functional components, an adjusted total electrical power consumption is not greater than the predefined total electrical power consumption. A biotechnological apparatus comprises a bioreactor, a reactor vessel formed in the bioreactor and having a cultivation chamber, and a temperature control device provided with a heat pump and configured to control the temperature of the cultivation chamber.

Abstract: A start-up circuit for a reference circuit such as a bandgap reference circuit. The start-up circuit includes a diode-connected metal-oxide-semiconductor (MOS) transistor connected between a power supply node and a start-up node that is connected in turn to the gate of a current control MOS transistor in the reference circuit. The diode-connected MOS transistor and the current control MOS transistor are matched with one another. To start up the reference circuit, current is conducted through the diode-connected MOS transistor to set the gate voltage of the current control transistor at a threshold voltage below the power supply voltage. Current conducted by the current control transistor initiates operation of the bandgap reference circuit, and disables the start-up circuit.

Abstract: A proportional to absolute temperature (PTAT) generator generates a current PTAT (IPTAT) and a fractional VBE in a first regulation loop. A level shifting voltage-to-current converter is arranged as a second regulation loop and is operable to generate a current ZTC (IZTC) and/or a voltage ZTC (VZTC). Both regulation loops are nested into each other. In an embodiment, the voltage-to-current converter is operable to sum a scaled voltage PTAT (VPTAT/Y) with the fractional VBE (VBE/X) to generate the ZTC signal. In another embodiment, the voltage-to-current converter is operable to sum a delta voltage threshold (?VTH) with the fractional VBE (VBE/X) to generate the ZTC signal.

Abstract: An integrated circuit is provided with a bandgap voltage reference circuit having a bandgap reference voltage output. A bandgap failure detection circuit is coupled to the bandgap reference voltage output. The bandgap failure detection forms a model value of the reference voltage from a first time, compares a present value of the reference voltage at a second time to the model value; and asserts a bandgap fail signal to indicate when the present value is less than the model value by a threshold value. The integrated circuit is reset by the bandgap fail signal. The detection circuit may be operated from a failsafe voltage domain that also allows a critical circuit to complete a pending operation during a reset.

Abstract: A proportional to absolute temperature (PTAT) generator, for example, generates a PTAT current (IPTAT) and a VBE (voltage base-to-emitter) in a first regulation loop. A voltage-to-current converter is operable to generate a complementary to absolute temperature current (ICTAT). The IPTAT and ICTAT are summed to obtain a zero temperature coefficient current (IZTC). One ICTAT and one resistor are used to generate the IZTC signal.

Abstract: A proportional to absolute temperature (PTAT) generator generates a current PTAT (IPTAT) and a fractional VBE in a first regulation loop. A level shifting voltage-to-current converter is arranged as a second regulation loop and is operable to generate a current ZTC (IZTC) and/or a voltage ZTC (VZTC). Both regulation loops are nested into each other. In an embodiment, the voltage-to-current converter is operable to sum a scaled voltage PTAT (VPTAT/Y) with the fractional VBE (VBE/X) to generate the ZTC signal. In another embodiment, the voltage-to-current converter is operable to sum a delta voltage threshold (?VTH) with the fractional VBE (VBE/X) to generate the ZTC signal.

Abstract: An integrated circuit is provided with a bandgap voltage reference circuit having a bandgap reference voltage output. A bandgap failure detection circuit is coupled to the bandgap reference voltage output. The bandgap failure detection forms a model value of the reference voltage from a first time, compares a present value of the reference voltage at a second time to the model value; and asserts a bandgap fail signal to indicate when the present value is less than the model value by a threshold value. The integrated circuit is reset by the bandgap fail signal. The detection circuit may be operated from a failsafe voltage domain that also allows a critical circuit to complete a pending operation during a reset.

Abstract: A start-up circuit for a reference circuit such as a bandgap reference circuit. The start-up circuit includes a diode-connected metal-oxide-semiconductor (MOS) transistor connected between a power supply node and a start-up node that is connected in turn to the gate of a current control MOS transistor in the reference circuit. The diode-connected MOS transistor and the current control MOS transistor are matched with one another. To start up the reference circuit, current is conducted through the diode-connected MOS transistor to set the gate voltage of the current control transistor at a threshold voltage below the power supply voltage. Current conducted by the current control transistor initiates operation of the bandgap reference circuit, and disables the start-up circuit.

Abstract: A bandgap reference circuit with curvature compensation. The circuit includes a first current mirror that mirrors the current conducted by the bandgap reference. A difference between the gate-to-source voltages in the two legs provides a first mirrored current with non-linear temperature stability. This first mirrored current is again mirrored by a second current mirror in which the mirror transistors also have differing gate-to-source voltages, with the current from this second current mirror coupled to the bandgap reference to compensate for curvature in the CTAT current over temperature.

Abstract: An electronic device that includes a power on reset, a variable power supply filter coupled to the power on reset, and control logic coupled to the power on reset and the variable power supply filter. The control logic is configured to activate the variable power supply filter based on a core domain of the electronic device being active.

Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.