Abstract: The present invention relates to new dihydropteridinones of general formula (I) 1

Abstract: Disclosed are dihydropteridinones of the formula (I): 1

Abstract: A compound of formula 1 1

Abstract: The invention relates to a driving unit especially adapted to adjusting devices for motor vehicles and comprising an electric motor (1), a gear box (2) and an electronic control device (15). The invention is characterized in that at least one element of the electric motor (1), for example, at the driving shaft (9), the magnetic short-circuit (5) or the motor side crankcase casing (11), additionally provides a gear box (2) mechanical feature and/or in that a mechanical member, for example, a gear box (12) side crankcase casing, provides an electric motor (1) or electronic control device (15) feature.

Abstract: The present invention relates to new dihydropteridinones of the formula (I) 1

Abstract: The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for lowering blood pressure levels.

Abstract: This invention involves a compound represented by the general formula (I): 1

Abstract: New imidazotriazolopyrimidine derivatives of the formula Preferred are those compounds wherein: R1 denotes methyl, which is optionally substituted by phenyloxy or pyrrole; or R1 denotes benzyl which is optionally substituted by hydroxy, methoxy, dimethylaminoethoxy or fluorine; or R1 denotes cyclopentyl, furan or phenylethyl; R2 or R3 denote ethyl, n-propyl, allyl or propargyl; R4 or R6 denote hydrogen; and, R5 denotes methyl, n-propyl, tert.butyl, cyclopentyl or norbornenyl. These are adenosine antagonists are are useful for, inter alia, the treatment of senile dementia of the Alzheimer's type.

Abstract: A compound of formula I or of tautomeric formula II 1

Abstract: A method for the continuous synthesis of baccatin-III is performed by means of the enzymatic acetylations of 10-deacetyl baccatin-III (10-DAB) in an enzyme reactor. This objective is accomplished by a method, for which an aqueous reaction batch is used, which contains a partially purified or a very pure acetyl transferase from a Taxus species and synthesis components, especially 10-DAB, acetyl compounds or optionally an acetyl coenzyme A, which can be regenerated, a protective colloid and optionally a buffer substance in solution. The solution is separated by a semipermeable membrane from an organic solvent, which serves as extraction agent for baccatin-III, the reaction batch being regenerated at regular intervals in an aqueous buffer system and the solvent continuously being exchanged. By conducting the reaction, the product can be removed continuously from the reaction batch for the partial synthesis of taxol and taxoter. By the above method, achievable yields are increased significantly.

Abstract: The invention relates to the use of tricyclic nitrogen heterocycles of general formula I as pharmaceutical compositions with an inhibitory effect on PDE IV, wherein the groups R1, R2 and R3 have the meanings given in the specification and claims.

Abstract: The invention comprises the use of activity-reducing effectors of dipeptidyl peptidase (DP IV) and DP IV-analogous enzyme activity in the blood of a mammal to lower the blood sugar level and the blood pressure in mammalian organisms.

Abstract: The present invention relates to N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula 1, processes for preparing such compounds, pharmaceutical compositions containing such compounds and methods for using such compounds for the treatment of various diseases caused by a functional disorder resulting from overstimulation.

Abstract: Asymmetrically substituted xanthine derivatives having adenosine A1 antagonistic activity. These are useful as pharmaceuticals. Exemplary are: (a) 3-(2-(2-acetyloxyethyl)sulphonylethyl)-8-(1-noradamantyl)-1-n-propyl-xanthine; (b) 3-(2-(hydroxyethyl)sulphonylethyl)-8-(1-noradamantyl)-1-n-propyl-xanthine; and, (c) 3-(2-(carbamoylethyl)-8-(1-noradanantyl)-1-n-propyl-xanthine.

Abstract: The present invention relates to ceramic bodies suitable for use in high temperature applications such as molten metal filters and kiln furniture. The ceramic bodies are formed from partially stabilized zirconia and are characterized by the presence of from about 12% to about 80% by weight zirconia in a monoclinic phase and the balance essentially in a cubic phase at room temperature. The ceramic bodies possess an excellent combination of physical properties including high temperature strength and thermal shock resistance. The invention also relates to the process for forming the ceramic bodies and the thixotropic ceramic slurry used therein.

Abstract: The present invention relates to ceramic bodies suitable for use in high temperature applications such as molten metal filters and kiln furniture. The ceramic bodies are formed from partially stabilized zirconia and are characterized by the presence of from about 12% to about 80% by weight zirconia in a monoclinic phase and the balance essentially in a cubic phase at room temperature. The ceramic bodies possess an excellent combination of physical properties including high temperature strength and thermal shock resistance. The invention also relates to the process for forming the ceramic bodies and the thixotropic ceramic slurry used therein.

Abstract: The solid cathodes built into reduction cells for aluminum production have at least one workface which can be wet by the precipitated metal. The starting materials, which contain titanium, boron and carbon in powder form, are first intimately mixed in such proportions that the sum of the powdered carbon and any carbon extracted from the substrate is in excess with respect to the amount required by the starting materials to form titanium diboride. This mixture is heated under a neutral or reducing atmosphere to 1600.degree.-2200.degree. C. and held for 5-45 min at this temperature. The reaction product containing pores and channels is then heated further, to 2250.degree.-2600.degree. C., and held there for 10-60 min to form a compact titanium diboride/carbon eutectic. Subsequently, the solid cathode is cooled to room temperature.

Abstract: The solid cathodes built into reduction cells for aluminum production have at least one workface which can be wet by the precipitated metal. The starting materials, which contain titanium, boron and carbon in powder form, are first intimately mixed in such proportions that the sum of the powdered carbon and any carbon extracted from the substrate is in excess with respect to the amount required by the starting materials to form titanium diboride. This mixture is heated under a neutral or reducing atmosphere to 1600.degree.-2200.degree. C. and held for 5-45 min at this temperature. The reaction product containing pores and channels is then heated further, to 2250.degree.-2600.degree. C., and held there for 10-60 min to form a compact titanium diboride/carbon eutectic. Subsequently, the solid cathode is cooled to room temperature.