Abstract: A method and system for autoregressive model based pigtail catheter motion prediction in a fluoroscopic image sequence is disclosed. Parameters of an autoregressive model are estimated based on observed pigtail catheter tip positions in a plurality of previous frames of a fluoroscopic image sequence. A pigtail catheter tip position in a current frame of the fluoroscopic image sequence is predicted using the fitted autoregressive model. The predicted pigtail catheter tip position can be used to constrain pigtail catheter tip detection in the current frame. The predicted pigtail catheter tip position may also be used to predict abnormal motion in the fluoroscopic image sequence.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: Robust calcification tracking is provided in fluoroscopic imagery. A patient with an inserted catheter is scanned over time. A processor detects the catheter in the patient from the scanned image data. The processor tracks the movement of the catheter. The processor also detects a structure represented in the data. The structure is detected as a function of movement with a catheter. The processor tracks the movement of the structure using sampling based on a previous location of the structure in the patient. The processor may output an image of the structure.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: A method and system for fusion of multi-modal volumetric images is disclosed. A first image acquired using a first imaging modality is received. A second image acquired using a second imaging modality is received. A model and of a target anatomical structure and a transformation are jointly estimated from the first and second images. The model represents a model of the target anatomical structure in the first image and the transformation projects a model of the target anatomical structure in the second image to the model in the first image. The first and second images can be fused based on estimated transformation.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: A method and system for aorta segmentation in a 3D volume, such as a C-arm CT volume is disclosed. The aortic root is detected in the 3D volume using marginal space learning (MSL) based segmentation. The aortic arch is detected in the 3D volume using MSL based segmentation. The ascending aorta is tracked from the aortic root to the aortic arch in the 3D volume, and the descending aorta is tracked from the aortic arch in the 3D volume.

Abstract: A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.

Abstract: A method for real-time fusion of a 2D cardiac ultrasound image with a 2D cardiac fluoroscopic image includes acquiring real time synchronized US and fluoroscopic images, detecting a surface contour of an aortic valve in the 2D cardiac ultrasound (US) image relative to an US probe, detecting a pose of the US probe in the 2D cardiac fluoroscopic image, and using pose parameters of the US probe to transform the surface contour of the aortic valve from the 2D cardiac US image to the 2D cardiac fluoroscopic image.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.

Abstract: A method and system for extracting a silhouette of a 3D mesh representing an anatomical structure is disclosed. The 3D mesh is projected to two dimensions. Silhouette candidate edges are generated in the projected mesh by pruning edges and mesh points based on topology analysis of the projected mesh. Each silhouette candidate edge that intersects with another edge in the projected mesh is split into two silhouette candidate edges. The silhouette is extracted using an edge following process on the silhouette candidate edges.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.