Abstract: The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.

Abstract: A method of checking the operability of an actuator is provided. The actuator includes a control valve adjustable via an actuating drive by an actuating element, a position sensor detecting the actual position of the actuating element, and an electropneumatic position controller creating a pneumatic controlled variable depending on an actual position and a target position. The target position is provided to the actuating drive via an activated magnetic valve. The actuating element is moved over a section of an adjustment path for an execution of a partial-stroke test of the actuating element, the adjustment movement being detected. The magnetic valve is deactivated for a short time such that the actuating element is moved over only a section of the adjustment path. To facilitate the monitoring of the operability of the actuator, the partial-stroke test and the test of the magnetic valve are performed in a single test sequence.

Abstract: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.

Abstract: A method for operating an electric control device for at least one power unit of a motor vehicle, an operating temperature range being assigned to the control device, and the control device being automatically switched off if its temperature exceeds the operating temperature range. A switch-on of the automatically switched-off control device may be implemented only if its temperature is within the operating temperature range. Furthermore, a corresponding electric control device.

Abstract: The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.

Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: A drive train having a clutch assembly for transmitting torque between an engine and a transmission. The clutch assembly is selectable for transmitting torque between the engine and the transmission and includes at least one friction clutch, the clutch assembly being supported on the transmission housing so that the clutch assembly is radially fixed and displaceable in an axially limited manner.

Abstract: In various embodiments of the present invention, methods are provided for transmitting scheduling requests over uplink channels. One embodiment includes determining whether a first resource for transmission of a scheduling request over an unscheduled uplink control channel is allocated concurrently with a second resource for transmission of user data over a scheduled uplink shared channel. This embodiment also includes encoding the user data and bit(s) of control information to form encoded information for transmission using the second resource. The additional bit(s) indicate whether the mobile unit is transmitting the scheduling request. Another embodiment includes determining whether a first resource for transmission of a scheduling request over an unscheduled uplink control channel is allocated concurrently with a second resource for transmission of other control information over the unscheduled uplink control channel.

Abstract: A process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate as well as rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate at a purity of at least 98.55% is described.

Abstract: The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.

Abstract: This invention concerns a method of providing a VoIP connection through wireless communication links of a packet-based wireless communication system, and a corresponding base station and terminal. The wireless communication links comprise an uplink transmission path (2uc, 2us) from the terminal to the base station, and a downlink transmission path (2dc, 2ds) from the base station to the terminal. Each of the uplink and downlink transmission paths (2uc, 2us, 2dc, 2ds) have a control channel (2uc, 2dc) and at least one data channel (2us, 2ds). Control messages (20d, 21d, 220u, 221u, 230d, 250u, 260u) are generated for scheduling network resources and for suspending and/or re-issuing a persistent grant of network resources allocated to the VoIP connection.

Abstract: The invention concerns a method of managing coexisting packet streams (100, 110) in a wireless communication system, and a corresponding controller and a mobile terminal. A first packet stream (110) of the coexisting packet streams (100, 110) requires transmission resources of the wireless communication system at fixed time intervals, and a second packet stream (100) of the coexisting packet streams (100, 110) requires transmission resources of the wireless communication system at dynamically determined time intervals. A schedule defining allocations of transmission resources for the first packet stream (110) is set up. A request for an initial grant of transmission resources for a transmission of a data packet (101) of the second packet stream (100) is issued.

Abstract: The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.

Abstract: A drive train having a clutch assembly for transmitting torque between an engine and a transmission. The clutch assembly is selectable for transmitting torque between the engine and the transmission and includes at least one friction clutch, the clutch assembly being supported on the transmission housing so that the clutch assembly is radially fixed and displaceable in an axially limited manner.

Abstract: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.

Abstract: Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention concerns a device for detecting and representing movements. The device includes a position sensor for detecting the current position of a reference point of the device, a data processor for processing the position data detected by the position sensor and a projector for projecting on a surface an image projection of the detected and processed position data. The data processor takes into account a modification in the current position of the reference point such that the projection image on the surface remains substantially stable concerning location and position.