Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Abstract: A semiconductor device for outputting a control parameter includes a receiving unit, a storage unit and an output unit. The semiconductor device also contains antenna connections, supply connections and at least one output connection for outputting a control parameter signal. The receiving unit contains connections for connection to an antenna, from which the receiving unit receives signals. The receiving unit converts the signals received from the antenna into data. The data are stored in the storage unit. The semiconductor device outputs an output signal at the output connection on the basis of the data stored in the storage unit. The semiconductor device additionally contains a calculation unit which determines the operating hours (time) of the semiconductor device. The output signal depends both on the data stored in the storage unit and on the determined operating hours (time).

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.

Abstract: A control circuit for a switching converter is described herein. In accordance with one embodiment the control circuit includes an analog bus that receives a plurality of input signals and a first set of functional units that are operable to receive at least some of the input signals via the analog bus and to process the input signals to generate digital output data based on the input signals. The control circuit further includes an event bus that has an event bus controller and a plurality of bus lines and a second set of functional units that are operable to receive the output data, via the event bus, from the functional units of the first set. At least one functional unit of the second set of functional units is operable to determine switching time instants for the switching converter based on the output data received via the event bus, and the event bus controller includes an arbiter operable to arbitrate data transmission across the bus lines.

Abstract: In a method for producing a component by further forming of a preformed contour of a blank, the blank which has previously been cut to size at ambient temperature from a strip or a metal sheet undergoes after optional further manufacturing steps carried out at ambient temperature, e.g. punching or cutting operations to realize recesses or openings, in selected edge regions that have been strain hardened by the punching or cutting operations to obtain a preformed contour a first forming operation at ambient temperature. The edge regions intended to undergo the forming operation or at least the edge regions that have undergone the first forming operation are heated to a temperature of at least 600° C. for maximal 10 seconds. After the heat treatment, the edge regions undergo at any time a second forming operation or further forming operations at ambient temperature with respectively preceding heat treatments.

Abstract: The invention relates to a method for the optimized production of a component, in particular from steel, with at least one secondary formed element, comprising the steps of a) providing a blank which has been cut to size at room temperature from a strip or a sheet and in which cut-outs and/or holes have optionally been created by stamping or cutting operations; b) thermal treatment of selected edge regions of the blank that have been cold-hardened by the stamping or cutting operations, in which the edge regions are heated to a temperature of at least 600° C.

Abstract: A container is provided having a container body (2), which forms a receiving space (3) for goods to be packaged. The container body (2) has a side wall (4) and a container base (5) connected integrally to the side wall (2), The container body (2) also has an opening (6), wherein the container body (2) has a chamber (13), which is filled with a solid treatment substance (14). The chamber (13) is provided with a cover (15), which prevents the solid treatment substance (14) from leaving the chamber (13) and is moisture-permeable and/or gas-permeable. The container is characterized in that the container body (2) has a synthetic material injection-moulded part, which forms the container base (5) and the side wall (4). The invention also relates to a method for producing such a container.

Abstract: A control circuit for a switching converter is described herein. In accordance with one embodiment the control circuit includes an analog bus that receives a plurality of input signals and a first set of functional units that are operable to receive at least some of the input signals via the analog bus and to process the input signals to generate digital output data based on the input signals. The control circuit further includes an event bus that has an event bus controller and a plurality of bus lines and a second set of functional units that are operable to receive the output data, via the event bus, from the functional units of the first set. At least one functional unit of the second set of functional units is operable to determine switching time instants for the switching converter based on the output data received via the event bus, and the event bus controller includes an arbiter operable to arbitrate data transmission across the bus lines.

Abstract: A container having a childproof safety device is provided. The container has a container body with a container opening, comprising a container closure for the container opening, said closure being movable from a closed to an open position, and comprising a removable tamper-proof element. A child safety device that comprises an actuating element is associated with the container closure. The invention is characterized in that the tamper-proof element blocks movement of at least a portion of the actuating element and in that after the tamper-proof element is removed at least a portion of the actuating element is movable from a first position, in which the container closure is secured, to a second position, in which the container closure is not secured.

Abstract: An electronic device is described herein. In accordance with one embodiment, the electronic device includes an embedded controller having a debug logic, an interface circuit coupled to the debug logic, and a memory coupled to the interface circuit. The interface circuit is operative to read debug information stored in the debug logic and to transmit the read debug information to the memory. The interface circuit is further operative to receive debug information stored in the memory and write the received debug information into the debug logic.

Abstract: The invention relates to a container having a container body with a container opening and a container closure. A hinge connects the container closure to the container body. The container body includes a container wall, which forms a container space. The container opening is surrounded by a rim. The container closure is a snap on closure movable between an open position and a closed position. The container closure has a base with a skirt. The container closure has a first sealing segment and a second sealing segment, wherein the first sealing segment is arranged on an inner side of the skirt and the second sealing segment is arranged on the base. In the closed position, the first sealing segment rests against an outer side of the rim and the second sealing segment rests against a front surface of the rim.

Abstract: A container having a childproof safety device is provided. The container has a container body with a container opening, comprising a container closure for the container opening, said closure being movable from a closed to an open position, and comprising a removable tamper-proof element. A child safety device that comprises an actuating element is associated with the container closure. The invention is characterized in that the tamper-proof element blocks movement of at least a portion of the actuating element and in that after the tamper-proof element is removed at least a portion of the actuating element is movable from a first position, in which the container closure is secured, to a second position, in which the container closure is not secured.

Abstract: An injection-molded container for dry-storage of goods to be packaged, has a container body (2), which has a container wall (3) and forms a receiving space (4) for goods to be packaged. A desiccant is arranged in the receiving space (4). The container body (2) has, in an end region (5), an opening (6) for removing the goods to be packaged, and a closure (8) for closing the opening (6. The closure (8) has a lid (9) and a hinge (10) which forms a pivot axis (11), about which the lid (9) can be pivoted, in order to move the lid (9) between a closed position and an open position. The lid (9), the hinge (10) and the container body (2) are injection-molded in one piece. The lid (9) and the hinge (10) are formed and arranged on the container body (2) such that in the open position the lid (9) does not protrude beyond the end region (5) of the container body (2). The lid (9) has a sealing section (13), which, in the closed position of the lid (9), is arranged in the opening (6) of the container body (2).

Abstract: A container is provided having a container body (2), which forms a receiving space (3) for goods to be packaged. The container body (2) has a side wall (4) and a container base (5) connected integrally to the side wall (2). The container body (2) also has an opening (6), wherein the container body (2) has a chamber (13), which is filled with a solid treatment substance (14). The chamber (13) is provided with a cover (15), which prevents the solid treatment substance (14) from leaving the chamber (13) and is moisture-permeable and/or gas-permeable. The container is characterized in that the container body (2) has a synthetic material injection-moulded part, which forms the container base (5) and the side wall (4). The invention also relates to a method for producing such a container.

Abstract: The present invention relates to methods for identifying markers for systemic sclerosis (also referred to as scleroderma; SSc) and the markers identified with the aid of this method, which can differentiate between SSc and other autoimmune diseases on the one hand and between different SSc subgroups on the other hand. The invention also relates to panels, diagnostic devices, and test kits which comprise these markers, and also to the use and application thereof, for example for the diagnosis, prognosis and therapy control of SSc. The invention also relates to methods for screening and for validating active substances for use in SSc subgroups.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.

Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Abstract: The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated diseases including atherosclerosis.

Abstract: A method is proposed for verification of time data from a time signal modulated on a continuous carrier signal with steps to receive a first time signal with a first reference time, to receive a second time signal with a second reference time, which follows the first reference time in time, for calculation of the target time interval lying between the reference times from the time data contained in the received time signal, to determine a time interval and determine a reference time interval, using counting of periods of the continuous carrier signal within the time interval, for comparison of the target time interval with the reference time interval and to send an error signal, if the deviation determined by the comparison surpasses a stipulated tolerance value.