Abstract: In one embodiment, a technique is provided for exchanging a design of a structure between a modeling application and an analysis application. The model of the structure is scanned in the modeling application, to identify model elements and their interrelationships. Using the identified model elements and their interrelationships, an analytical interface model is generated within the modeling application that provides an abstracted representation of the structure. Such analytical interface model is viewable and modifiable within the user interface of the modeling application. Information regarding the analytical interface model is transferred to the analysis application. This information is used by the analysis application to create a separate analytical model maintained and used by the analysis application.

Abstract: The present invention relates generally to amide containing heterobicyclic compounds having the following formulas: wherein R1, R2, D, and Q are as defined in the specification. More particularly, the present invention provides a new class of amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: A method for synchronizing a rotation speed of a permanently excited rotor of an electric motor with a frequency of a rotation field of a sensorless commutated stator of the electric motor during a run-up procedure of the electric motor includes determining a phase position of the rotation field and a phase position of a countervoltage that is induced by the rotor in the stator in order to obtain a phase offset between the rotation field and the countervoltage. The method further includes adjusting a prevailing amplitude of one component of the rotation field using the phase offset to synchronize the rotation speed with the frequency. The amplitude of the component is increased if the rotor is lagging behind the rotation field or the amplitude of the component is reduced if the rotor is running ahead of the rotation field.

Abstract: A dispenser for administering strip-shaped substances, includes a housing having a chamber to store a stack of the strip-shaped substances and forming a removal opening for the strip-shaped substances that can be opened and closed again with a lid, said lid being joined to the housing, and being joined to a transport bar that can be moved together with the lid in order to transport the strip-shaped substances. The objective of designing and refining a dispenser of the above-mentioned type in such a manner as to allow a contamination-free and reliable transport of one single strip-shaped substance from the inside of the housing merely by moving the lid is characterized in that the transport bar is elastically pre-tensioned and mounted in the housing in such a way that it is at a distance from the stack when the removal opening is closed.

Abstract: The invention relates to novel marker sequences for systemic lupus erythematosus and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for systemic lupus erythematosus diseases using said marker sequences. The invention further relates to a diagnostic device containing such marker sequences for systemic lupus erythematosus, especially to a protein biochip and the use thereof.

Abstract: A wrap-around braking device for a planetary gear train, having at least one wrap-around element, with first and second cam devices, and is designed to wrap around at least one ring gear of the planetary gear train for braking engagement. A shift fork, which can be moved in the axial direction of the shift fork and which has first and second actuating elements that act oppositely in the axial direction and which is mounted in a rotationally fixed manner in a housing that has at least first and second stops in the axial direction. For braking engagement on the ring gear, which rotates in a first rotational direction, the shift fork can be moved in a first axial direction such that the first actuating element interacts with the first cam device, while the second stop opposite the first actuating element in the axial direction interacts with the second cam device.

Abstract: A hybrid module for a drive train of a vehicle having an internal combustion engine and a transmission. The hybrid module operates between the internal combustion engine and the transmission and has an electric drive, a clutch, and a freewheel, and the clutch and the freewheel are provided parallel to each other in order to transmit torque from the internal combustion engine toward the transmission, the freewheel transmits torque coming from the internal combustion engine to the transmission and opens for torque directed in the opposite direction, and a portion of the torque produced by the internal combustion transmitted by the freewheel can be set by setting a torque that can be transmitted by the clutch so that the vehicle can be driven by the internal combustion engine or the electric drive or both at the same time.

Abstract: A method for operating an electric control device for at least one power unit of a motor vehicle, an operating temperature range being assigned to the control device, and the control device being automatically switched off if its temperature exceeds the operating temperature range. A switch-on of the automatically switched-off control device may be implemented only if its temperature is within the operating temperature range. Furthermore, a corresponding electric control device.

Abstract: A solid cone nozzle comprises a nozzle housing and a swirl insert, wherein said nozzle housing has an outlet chamber including a discharge orifice and wherein the outlet chamber is disposed downstream of the swirl insert. The swirl insert has on its external periphery at least one swirl duct, which extends, in a swirl portion, helically or at an angle to the longitudinal center axis of the swirl insert and which extends in the axial direction in an outlet portion, which outlet portion extends from the end of the swirl portion to the downstream end of the swirl duct.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

Abstract: A dispenser for administering strip-shaped substances (1), comprising a housing (2, 2?), said housing (2, 2?) having a chamber (3, 3?) to store a stack (4) of the strip-shaped substances (1), said housing (2, 2?) forming a removal opening (5, 5?) for the strip-shaped substances (1) that can be opened and closed again with a lid (6, 6?), said lid (6, 6?) being joined to the housing (2, 2?), and said lid (6, 6?) being joined to a transport bar (7, 7?) that can be moved together with the lid (6, 6?) in order to transport the strip-shaped substances (1), in view of the objective of designing and refining a dispenser of the above-mentioned type in such a manner as to allow a contamination-free and reliable transport of one single strip-shaped substance from the inside of the housing merely by moving the lid, is characterized in that the transport bar (7, 7?) is elastically pre-tensioned and mounted in the housing (2, 2?) in such a way that it is at a distance from the stack (4) when the removal opening (5, 5?) is

Abstract: The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.

Abstract: A tank-cleaning nozzle having an inlet tube, a cleaning head mounted for rotation on the inlet tube and at least one spray nozzle disposed on the cleaning head. The spray nozzle is in the form of a fluidic oscillator nozzle producing an oscillation solid jet at an outlet from the nozzle.

Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

Abstract: The present invention relates to 11?-fluoro-3-acetoxyestra-3,5-dien-17-one as a suitable intermediate in the preparation of 11-fluoro-substituted steroids and to the process for preparation thereof. For this purpose, 11?-hydroxyestra-4-ene-3,17-dione is reacted with 1 to 3 equivalents of n-nonafluorobutanesulfonyl fluoride and 3 to 5 equivalents of diazabicycloundecene (DBU) at ?40 to ?20° C. in an organic aprotic solvent and, after an aqueous workup, reacted with 5 to 10 equivalents of acetic anhydride and 0.01 to 1 equivalent of a strong acid. The desired product precipitates spontaneously out of the reaction solution and is obtained in a very high purity by filtration. The process is notable for the very high yield, avoidance of a chromatographic purification of the product, a reduced proportion of wastes and significantly increased process throughput. The process according to the invention is therefore especially suitable for preparing 11?-fluoro-3-acetoxyestra-3,5-dien-17-one on a large industrial scale.

Abstract: A method (10) for respiratory motion compensation by applying principle component analysis (PCA) on cardiac imaging samples obtained using 2D/3D registration of a pre-operative 3D segmentation of the coronary arteries.

Abstract: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.