Abstract: An inhaler vaporizer cartridge includes a housing body with a flow channel, a liquid storage tank, and a vaporizer unit. The vaporizer unit has a wick member and heating member and is liquid-permeable such that liquid is conveyed from the tank through the vaporizer unit to the flow channel. The housing body has a cavity forming the tank and a wick member receiving chamber, and housing is divided by an intermediate wall and a flow channel section. An access opening from the receiving chamber to the flow channel is formed in the intermediate wall and covered by the heating member. Granular grains in the receiving chamber form the wick member and bear against the heating member. The grains form microchannels and are retained by a cover element. An access opening, covered with a liquid-permeable grid structure, establishes a liquid connection from the tank to receiving chamber in the intermediate wall.

Abstract: A vaporizer cartridge for an inhaler has a hollow body with a continuous flow channel and liquid storage tank. The tank has an access opening to the channel and a vaporizer unit extending over the entire access opening. The vaporizer unit has a wick member and a heating member. The vaporizer unit is liquid-permeable such that liquid is conveyed at least initially in a capillary manner from the storage tank through the vaporizer unit in the direction of the flow channel. The wick member is formed from a plurality of granular grains which, as a result of their fill and/or formation, form microchannels which establish a fluid connection between the storage tank and the flow channel, continuously from an entry side to an exit side of the wick member. An additional securing means is provided which is holds the granular wick member in position. A corresponding inhaler is also provided.

Abstract: A measurement arrangement for determining the duration of thermal dispersion hardening of a metal sheet wherein the metal sheet is connected to a current or voltage source via a first electrical contact face and a second electrical contact face and to a voltage or current measurement device via a third electrical contact face and a fourth electrical contact face, wherein the first electrical contact face lies completely within a face consisting of the intersecting faces of a front side, a rear side, and a side faces with an imaginary first cylinder, wherein the cylinder axis of the imaginary first cylinder passes through one of the corners of the front side the second electrical contact face lies completely within a face consisting of the intersecting faces of the front side, the rear side, and the side faces with an imaginary second cylinder.

Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: An electric contact element comprises a bent portion. The bent portion has a cross-section including at least one of a plastically flattened side in the bent portion or a corner that has a chamfer in the bent portion for maintaining accuracy of a bending process used to form the bent portion.

Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA. Other aspects provide methods for determining the presence or absence of methylation of at least one cytosine, or a series of cytosines in cis, in human DNA of a blood sample, a plasma sample, a serum sample or a urine sample from a human individual.

Abstract: A textile fabric for preventing the penetration and water spreading in cables, having at least one layer, which is at least partially covered by an absorbent material and has pores, which pores can be at least partially closed under the effect of liquid due to absorbent material swelling, the absorbent material being bonded to the textile layer, at least in some areas, has a DIN ISO 9073-3 tensile strength in machine direction of >50 N/5 cm, and obtainable by a method involving: treating a layer containing pores with a mixture containing a polymerizable monomer or oligomer and a cross-linking agent and, as absorbent material precursor, a wetting agent and initiator, and polymerization of the monomer or oligomer under formation of a bonded connection between the absorbent material and the layer. The textile fabric can have a DIN EN ISO 9237 air permeability in dry state of greater than 200 dm3/(m2s).

Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: An electric contact element comprises a bent portion. The bent portion has a cross-section with a corner that has a chamfer at least in the bent portion.

Abstract: A textile fabric for preventing the penetration and water spreading in cables, having at least one layer, which is at least partially covered by an absorbent material and has pores, which pores can be at least partially closed under the effect of liquid due to absorbent material swelling, the absorbent material being bonded to the textile layer, at least in some areas, has a DIN ISO 9073-3 tensile strength in machine direction of >50 N/5 cm, and obtainable by a method involving: treating a layer containing pores with a mixture containing a polymerizable monomer or oligomer and a cross-linking agent and, as absorbent material precursor, a wetting agent and initiator, and polymerization of the monomer or oligomer under formation of a bonded connection between the absorbent material and the layer. The textile fabric can have a DIN EN ISO 9237 air permeability in dry state of greater than 200 dm3/(m2s).

Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.

Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.

Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.

Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.

Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.