Patents by Inventor Matthias Schuster
Matthias Schuster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220154287Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: ApplicationFiled: October 28, 2021Publication date: May 19, 2022Inventors: Catherine E. LOFTON-DAY, Andrew Z. SLEDZIEWSKI, Ralf LESCHE, Matthias SCHUSTER, Juergen DISTLER, Reimo TETZNER, Thomas HILDMANN, Fabian MODEL, Xiaoling SONG
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Patent number: 11186879Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: GrantFiled: June 26, 2019Date of Patent: November 30, 2021Assignee: EPIGENOMICS AGInventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
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Patent number: 10770856Abstract: An electric contact element comprises a bent portion. The bent portion has a cross-section including at least one of a plastically flattened side in the bent portion or a corner that has a chamfer in the bent portion for maintaining accuracy of a bending process used to form the bent portion.Type: GrantFiled: October 16, 2018Date of Patent: September 8, 2020Assignee: TE Connectivity Germany GmbHInventors: Manuel Eder, Andreas Merkle, Matthias Schuster, Juergen Burger
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Patent number: 10731215Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA. Other aspects provide methods for determining the presence or absence of methylation of at least one cytosine, or a series of cytosines in cis, in human DNA of a blood sample, a plasma sample, a serum sample or a urine sample from a human individual.Type: GrantFiled: April 17, 2006Date of Patent: August 4, 2020Assignee: EPIGENOMICS AGInventors: Matthias Ballhause, Kurt Berlin, Theo De Vos, Dimo Dietrich, Volker Liebenberg, Catherine Lofton-Day, Joe Lograsso, Jennifer Maas, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner
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Patent number: 10689798Abstract: A textile fabric for preventing the penetration and water spreading in cables, having at least one layer, which is at least partially covered by an absorbent material and has pores, which pores can be at least partially closed under the effect of liquid due to absorbent material swelling, the absorbent material being bonded to the textile layer, at least in some areas, has a DIN ISO 9073-3 tensile strength in machine direction of >50 N/5 cm, and obtainable by a method involving: treating a layer containing pores with a mixture containing a polymerizable monomer or oligomer and a cross-linking agent and, as absorbent material precursor, a wetting agent and initiator, and polymerization of the monomer or oligomer under formation of a bonded connection between the absorbent material and the layer. The textile fabric can have a DIN EN ISO 9237 air permeability in dry state of greater than 200 dm3/(m2s).Type: GrantFiled: September 1, 2015Date of Patent: June 23, 2020Assignee: CARL FREUDENBERG KGInventors: Dominic Kramer, Ulrich Schneider, Gerald Jarre, Matthias Schuster, Nermina Zaplatilek, Marco Sutter, Iain Smith
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Publication number: 20190316210Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: ApplicationFiled: June 26, 2019Publication date: October 17, 2019Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
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Patent number: 10385402Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: GrantFiled: March 23, 2016Date of Patent: August 20, 2019Assignee: EPIGENOMICS AGInventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
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Publication number: 20190115707Abstract: An electric contact element comprises a bent portion. The bent portion has a cross-section with a corner that has a chamfer at least in the bent portion.Type: ApplicationFiled: October 16, 2018Publication date: April 18, 2019Applicant: TE Connectivity Germany GmbHInventors: Manuel Eder, Andreas Merkle, Matthias Schuster, Juergen Burger
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Publication number: 20170298568Abstract: A textile fabric for preventing the penetration and water spreading in cables, having at least one layer, which is at least partially covered by an absorbent material and has pores, which pores can be at least partially closed under the effect of liquid due to absorbent material swelling, the absorbent material being bonded to the textile layer, at least in some areas, has a DIN ISO 9073-3 tensile strength in machine direction of >50 N/5 cm, and obtainable by a method involving: treating a layer containing pores with a mixture containing a polymerizable monomer or oligomer and a cross-linking agent and, as absorbent material precursor, a wetting agent and initiator, and polymerization of the monomer or oligomer under formation of a bonded connection between the absorbent material and the layer. The textile fabric can have a DIN EN ISO 9237 air permeability in dry state of greater than 200 dm3/(m2s).Type: ApplicationFiled: September 1, 2015Publication date: October 19, 2017Inventors: Dominic Kramer, Ulrich Schneider, Gerald Jarre, Matthias Schuster, Nermina Zaplatilek, Marco Sutter, Iain Smith
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Patent number: 9695478Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: GrantFiled: May 13, 2010Date of Patent: July 4, 2017Assignee: EPIGENOMICS AGInventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
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Publication number: 20170067119Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.Type: ApplicationFiled: August 15, 2016Publication date: March 9, 2017Inventors: Andrew Z. Sledziewski, Shannon Payne, Matthias Schuster, Joern Lewin, Thomas Schlegel, Andrew M. Morotti
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Publication number: 20160304964Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: ApplicationFiled: March 23, 2016Publication date: October 20, 2016Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
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Publication number: 20150176062Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.Type: ApplicationFiled: February 23, 2015Publication date: June 25, 2015Inventors: Matthias Ballhause, Kurt Berlin, Dimo Dietrich, Antje Kluth Lukas, Matthias Schuster, Ute Wagner, Reinhold Wasserkort, Heike Ziebarth
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Publication number: 20150086989Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: ApplicationFiled: November 19, 2014Publication date: March 26, 2015Inventors: Juergen Distler, Thomas Hildmann, Ralf Lesche, Catherine Lofton-Day, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner, Xiaoling Song
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Patent number: 8962246Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.Type: GrantFiled: December 2, 2013Date of Patent: February 24, 2015Assignee: Epigenomics AGInventors: Matthias Ballhause, Kurt Berlin, Dimo Dietrich, Antje Kluth Lukas, Matthias Schuster, Ute Wagner, Reinhold Wasserkort, Heike Ziebarth
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Patent number: 8900829Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.Type: GrantFiled: April 28, 2011Date of Patent: December 2, 2014Assignee: Epigenomics AGInventors: Juergen Distler, Thomas Hildmann, Ralf Lesche, Catherine Lofton-Day, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner, Xiaoling Song
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Publication number: 20140087449Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc.). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.Type: ApplicationFiled: December 2, 2013Publication date: March 27, 2014Applicant: Epigenomics AGInventors: Matthias Ballhause, Kurt Berlin, Dimo Dietrich, Antje Kluth Lukas, Matthias Schuster, Ute Wagner, Reinhold Wasserkort, Heike Ziebarth
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Patent number: 8679745Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and where the isolated genomic DNA is free of associated or cross-linked contaminants like proteins, peptides, amino acids or RNA. The methods are facile, cost-effective, and are characterized by high reproducibility and reliability. Particular aspects provide methods for providing DNA fragments derived from an archived sample, wherein the yield of DNA before, for example, an amplification step is at least 20%, and amplicons up to a length of about 1,000 base pairs are amplifiable.Type: GrantFiled: September 30, 2005Date of Patent: March 25, 2014Assignee: Epigenomics AGInventors: Matthias Ballhause, Kurt Berlin, Dimo Dietrich, Antje Kluth Lukas, Matthias Schuster, Ute Wagner, Reinhold Wasserkort, Heike Ziebarth
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Patent number: 8646728Abstract: A load lifting apparatus for a helicopter has a cable, including a supply length in a cable store. The cable is secured at one end to the helicopter and has a free end. A load-bearing element, on which a load to be raised can be secured, is arranged on the cable. The cable can be removed from the cable store in order to lower the load-bearing element downwards from the helicopter. As the load-bearing element is lowered or pulled upwards, the cable acts at a force-introduction location on the helicopter. The load-bearing element is arranged on the cable such that it can move along the cable. At least one cable-attachment location is present on the helicopter, and is spaced apart from the force-introduction location and has, or can have, the free end of the cable secured on it.Type: GrantFiled: December 14, 2011Date of Patent: February 11, 2014Inventor: Matthias Schuster
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Patent number: 8623599Abstract: Aspects of the invention relate to composition and methods for the providing of DNA for methylation analysis that is in particular suitable to be applied in reference laboratories. Further 5 aspects of the invention relate to composition and methods for the highly specific and sensitive methylation analysis of the Septin 9 gene also in particular suitable to be applied in reference laboratories.Type: GrantFiled: June 6, 2008Date of Patent: January 7, 2014Assignee: Epigenomics AGInventors: Theo Devos, Cathy Lofton-Day, Andrew Sledziewski, Fabian Model, Michael Krouse, Jesse Ho, Matthias Schuster, Juergen Distler, Reimo Tetzner