Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: A method of providing a male mold half for molding a toric contact lens at a predetermined target rotational orientation is disclosed. The method comprises the steps of: —providing the male mold half at a predetermined rotational orientation, —picking the male mold half up with a gripper having a central axis, —rotating the gripper with the male mold half about the central axis of the gripper by a predetermined rotational angle (?) towards the predetermined target rotational orientation, and —releasing the rotated male mold half from the gripper. Prior to picking the male mold half up, the method comprises centering the grippe and the male mold half relative to each other such that the central axis of the gripper and a central axis of the male mold half coincide.

Abstract: A lens care container (1), in particular for contact lenses such as hard or soft contact lenses, comprises: a receptacle (2) for receiving a lens and a lens care liquid, a cap (3) configured to be attached to the receptacle (2) to close the receptacle (2), a sensor (5) configured to indicate an actual loading of the container (1) with germs or configured to indicate a pH value of the lens care liquid in the receptacle (2). The sensor (5) is arranged in the receptacle (2) when the cap (3) is attached to the receptacle (2).

Abstract: An injection molding apparatus for manufacturing an ophthalmic lens mold having a front surface comprising a lens forming portion and a rear surface, comprises a first molding tool and a second molding tool. The first and second molding tools are movable towards and away from each other between a closed position and an open position. In the closed position the first mold forming portion of the first molding tool and the second mold forming portion of the second molding tool define a cavity between them corresponding in shape to the shape of the ophthalmic lens mold. The surface of the second mold forming portion, at least in a central zone thereof, has a surface roughness Sa in the range of 0.3 ?m to 2 ?m, and a surface roughness Sz in the range of 10 ?m to 50 ?m.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: an inspection module (21); Wherein the inspection module comprising a rail system in which self-driving shuttles carrying the inspection cuvettes are arranged on a closed-loop rail, wherein the rail system can be adapted to the available space in the production plant/hall using curves and straight portions in the manner known from a model railway.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end comprising: a first and a second injection-molding machine, a casting module, a filling station and a capping station, a stacking module and a curing module, a destacking module and a demolding and delensing module a production line back end comprising: a treatment module, an inspection module, wherein self-driving shuttles in the inspection module can form a queue and act as a buffer for the primary packaging module if an interruption of the primary packaging module and variations of the cycle time in the primary packaging module are buffered so that the extraction module is able to operate largely independently from the upstream and downstream components of the manufacturing line.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20); an inspection module (21); a primary packaging module (22), Wherein the first and second injection-molding machines allow for a quick exchange of the tooling plates used in the injection molding machine without the need to decrease the temperature of the injection molding machine by pre-configured tooling plates.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a treatment module (20), an inspection module (21), wherein the production line has the easy adaptability of curing times and temperatures, and in the capability of using different treatment liquids and treatment times in the extraction module to achieve the product flexibility.

Abstract: A device for cultivating tissue sections, in particular for testing active ingredients and/or medications, includes a frame, at least one carrier component designed to hold a tissue section, and at least one liquid-absorbing strip element. The frame is designed to hold the at least one carrier component and the at least one strip element. A cultivation system includes the device for cultivating tissue sections and a holding vessel. The device can be used for testing active ingredients or medications on a tissue (section).

Abstract: A mold unit (22) for molding ophthalmic lenses comprises: an adapter piece (220) comprising an opening (2200) extending around a longitudinal axis (2201); a sleeve (221) fixedly connected to the adapter piece (220) and extending through the opening (2200) of the adapter piece (220); a lens mold (222) rigidly mounted to the sleeve (221); an adjustment ring (224) firmly attached to the sleeve (221) to circumferentially surround a portion of the sleeve (221). The adjustment ring (224) comprises a flat circular outer engagement surface (2244), and the adapter piece (220) comprises at least one clamping block (2211) having a flat inner clamping surface (2214).

Abstract: The present invention relates to a method for determining in a subject's biological sample the relative proportions of papillary renal cell carcinoma (pRCC), clear cell renal cell carcinoma (ccRCC), and chromophobe renal cell carcinoma (chRCC), an array comprising capture molecules capable of specifically binding to RCC signature genes or coding sequences thereof or products encoded thereby, and the use of RCC signature genes for classifying a subject into a renal cell carcinoma (RCC) risk group and/or for determining in a subject's biological sample the relative proportions of pRCC, ccRCC, and chRCC.

Abstract: The present invention relates to a compound for use in the treatment or prevention of a liver disease, wherein the compound is a amyloid beta related protein, the amyloid beta related protein being selected from the group consisting of amyloid beta protein, a amyloid beta peptide derived therefrom, amyloid precursor protein (APP), a compound involved in the generation of an amyloid beta peptide from APP, or a compound inhibiting the degradation of the amyloid beta protein or of amyloid peptides derived therefrom.

Abstract: A method of providing a male mold half (1) for molding a toric contact lens at a predetermined target rotational orientation is disclosed. The male mold half comprises a front face (10) having a toric convex lens-forming surface (100) and a rear face (11) The method comprises the steps of: providing the male mold half (1) at a predetermined rotational orientation (PROM), picking the male mold half (1) up with a gripper (5) having a central axis (55), rotating the gripper (5) with the male mold half (1) about the central axis (55) of the gripper (5) by a predetermined rotational angle (?) towards the predetermined target rotational orientation (TROM), and releasing the rotated male mold half (1) from the gripper (5). Prior to picking the male mold half (1) up, the method comprises centering the gripper (5) and the male mold half (1) relative to each other such that the central axis (55) of the gripper and a central axis (113) of the male mold (1) half coincide.

Abstract: A lens care container (1), in particular for contact lenses such as hard or soft contact lenses, comprises: a receptacle (2) for receiving a lens and a lens care liquid, a cap (3) configured to be attached to the receptacle (2) to close the receptacle (2), a sensor (5) configured to indicate an actual loading of the container (1) with germs or configured to indicate a pH value of the lens care liquid in the receptacle (2). The sensor (5) is arranged in the receptacle (2) when the cap (3) is attached to the receptacle (2).

Abstract: Process for further use of a water-containing carbon raw material comprising the treatment of the carbon raw material with carbon dioxide or water vapor or a mixture thereof at elevated temperature and the admixing of the thus obtained carbon material with an acid.

Abstract: A load transfer interface for a vehicle door that comprises an outer skin and at least one beam that is connected to the outer skin, wherein the outer skin and the at least one beam define a vehicle door plane, the load transfer interface comprising at least one door stop fitting that is provided to transfer pressure loads from the vehicle door to an associated vehicle structural frame, the at least one door stop fitting being provided for rotation in an associated rotation plane, wherein the associated rotation plane is at least approximately parallel to the vehicle door plane. The invention is further related to an aircraft cabin door having such a load transfer interface, as well as to an aircraft having such an aircraft cabin door.

Abstract: A method for determining the inversion state of a soft contact lens (1), comprising imaging a soft contact lens having a convex surface (2, 3) and a concave surface (3, 2), a lens center and a lens edge (5) surrounding said soft contact lens (1), the method comprising using an optical coherence tomography system to obtain at least one sectional image of at least a part of the contact lens (1) comprising the lens edge (5), determining a cross-sectional edge geometry of the contact lens (1) extending from the lens edge (5) towards the lens center of the contact lens in the sectional image, the cross-sectional edge geometry corresponding to the convex and concave surface boundaries of the contact lens (1) in the sectional image, selecting a parameter defining the cross-sectional edge geometry of the contact lens (1) imaged and comparing the parameter defining the cross-sectional edge geometry of the contact lens (1) with a predetermined parameter defining a cross-sectional edge geometry of a non-inverted contact

Abstract: Process for further use of a water-containing carbon raw material comprising the treatment of the carbon raw material with carbon dioxide or water vapor or a mixture thereof at elevated temperature and the admixing of the thus obtained carbon material with an acid.