Patents by Inventor Matthias Schwab

Matthias Schwab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic methods for therapeutic compounds and methods for monitoring azathioprine therapy
    Patent number: 7524851
    Abstract: The present invention provides diagnostic methods for predicting therapeutic efficacy in an individual being treated for an autoimmune or an inflammatory disease. In addition, the present invention also provides novel methods for monitoring azathioprine therapy or optimizing clinical responsiveness to azathioprine therapy in an individual by measuring 6-thioguanosine nucleotide levels in a sample from the individual.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: April 28, 2009
    Assignee: Robert Bosch Gesellschaft fur Medizinische Forschung (RBMF)
    Inventors: Markus F. Neurath, Matthias Schwab
  • Polymorphisms in the human gene for tpmt and their use in diagnostic and therapeutic applications
    Publication number: 20060078879
    Abstract: The present invention relates to a polymorphic TPMT polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells.
    Type: Application
    Filed: February 4, 2003
    Publication date: April 13, 2006
    Inventors: Matthias Schwab, Elke Schaeffeler
  • Diagnostic methods for therapeutic compounds and methods for monitoring azathioprine therapy
    Publication number: 20050220709
    Abstract: The present invention provides diagnostic methods for predicting therapeutic efficacy in an individual being treated for an autoimmune or an inflammatory disease. In addition, the present invention also provides novel methods for monitoring azathioprine therapy or optimizing clinical responsiveness to azathioprine therapy in an individual by measuring 6-thioguanosine nucleotide levels in a sample from the individual.
    Type: Application
    Filed: December 2, 2004
    Publication date: October 6, 2005
    Applicant: Robert Bosch Gesellschaft fur Forschung (RBMF) Managing Director: U Hipp
    Inventors: Markus Neurath, Matthias Schwab