Patents by Inventor Matthias Wald
Matthias Wald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8848268Abstract: A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.Type: GrantFiled: September 17, 2010Date of Patent: September 30, 2014Assignee: Carl Zeiss Microscopy GmbHInventors: Helmut Lippert, Matthias Wald, Michael Goelles, Robert Hauschild
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Publication number: 20120281264Abstract: A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.Type: ApplicationFiled: September 17, 2010Publication date: November 8, 2012Applicant: CARL ZEISS MICROIMAGING GMBHInventors: Helmut Lippert, Matthias Wald, Michael Goelles, Robert Hauschild
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Publication number: 20120229791Abstract: A microscope including an illumination device providing a light sheet illuminating a sample region, said sheet having a planar extension along an illumination axis of an illumination beam path and a transverse axis lying normal to the illumination axis. A detection device detects light emitted from the sample region on a detection axis the illumination axis and detection axis as well as the transverse axis and the detection axis being oriented relative each other at an angle unequal zero. The detection device has a detection lens system arranged in the detection beam path and splitting means for splitting the detection beam path into two beam sub-paths. A dichroic beam splitter in the infinity region of the surface detectors is about 3 mm thick. Wobble plate(s) disposed orthogonal to each other relative to the detection axis arranged in one of the two beam sub-paths so measured values can be automatically superimposed.Type: ApplicationFiled: September 17, 2010Publication date: September 13, 2012Applicant: CARL ZEISS MICROIMAGING GMBHInventors: Helmut Lippert, Matthias Wald, Michael Goelles, Robert Hauschile, Wolfgang Bathe
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Publication number: 20120200693Abstract: A family of microscopes with illumination systems directing a sheet of light having an approximately planar extension in an illumination axis of an illumination beam path and in a transverse axis orthogonally oriented to the illumination axis. The microscopes have detection devices used to detect light that is emitted by a sample region. The detection devices including a detection lens system disposed in the detection beam path and an optical detection element spaced from a front lens of the detection lens system and independently adjustable thereof. The optical detection element continuously varies the size of a detection image field and/or continuously displaces a focal plane of detection in the P-region.Type: ApplicationFiled: September 17, 2010Publication date: August 9, 2012Applicant: CARL ZEISS MICROIMAGING GMBHInventors: Helmut Lippert, Christopher Power, Robert Hauschild, Matthias Wald
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Patent number: 8207510Abstract: A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.Type: GrantFiled: March 7, 2011Date of Patent: June 26, 2012Assignee: Carl Zeiss Micro Imaging GmbHInventors: Michael Kempe, Gerhard Krampert, Matthias Wald, Ralf Wolleschensky
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Publication number: 20110215258Abstract: A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.Type: ApplicationFiled: March 7, 2011Publication date: September 8, 2011Inventors: Michael KEMPE, Gerhard KRAMPERT, Matthias WALD, Ralf WOLLESCHENSKY
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Patent number: 7787179Abstract: The invention is directed to an optical arrangement with a light source for emitting a light bundle and with optical elements for transforming this light bundle into the shape of a light sheet, particularly suitable for illuminating individual planes of a three-dimensional specimen in selective plane illumination microscopy (SPIM). According to the invention, means are provided for varying the cross section of the light sheet, for varying the length of the light sheet and/or for influencing the direction in which individual beam components extending within the light sheet are directed to the specimen substance. This makes it possible to adapt the geometry of the light sheet to the illumination requirements for observing one and the same specimen plane with a plurality of different objectives and, if required, to reduce shadows occurring within the observed specimen plane as a result of the illumination.Type: GrantFiled: November 28, 2007Date of Patent: August 31, 2010Assignee: Carl Ziess MicroImaging GmbHInventors: Helmut Lippert, Matthias Wald, Benno Radt
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Publication number: 20100195198Abstract: The invention relates to a microscope illumination comprising at least one laser light source that emits a light beam, beam-guiding optical elements for generating an illumination beam path with distinguished planes, such as pupil and field planes, and a homogenizing arrangement for forming a luminous field that is homogenized with respect to the intensity and is to be directed onto a sample to be observed.Type: ApplicationFiled: May 31, 2008Publication date: August 5, 2010Inventors: Mario Längle, Matthias Wald
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Patent number: 7692879Abstract: A correction device for an imaging optical arrangement exhibiting a light path (1), in particular for a microscope, that exhibits at least one plane-parallel transparent plate (9), which is held in a mounting plate in the image beam path (1) and is propelable around at least one axle in a tipping and/or a swiveling motion, in order in adjust a definite parallel misalignment of the beams in the image beam path (1) by a change in the tipping situation of the plate (9). A confocal microscope with such a correction device exhibits a confocal screen (4), which illustrates a specimen mark (10), whereby the plane-parallel plate (9) is placed in front of the detector unit (2) in the light path (1), in order to center the illustration of the aperture diaphragm on the detector unit.Type: GrantFiled: June 29, 2007Date of Patent: April 6, 2010Assignee: Carl Zeiss MicroImaging GmbHInventors: Joerg Steinert, Matthias Wald, Saskia Pergande
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Publication number: 20090250632Abstract: A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.Type: ApplicationFiled: October 2, 2007Publication date: October 8, 2009Inventors: Michael Kempe, Gerhard Krampert, Matthias Wald, Ralf Wolleschensky
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Publication number: 20090237765Abstract: The invention is directed to an optical arrangement with a light source for emitting a light bundle and with optical elements for transforming this light bundle into the shape of a light sheet, particularly suitable for illuminating individual planes of a three-dimensional specimen in selective plane illumination microscopy (SPIM). According to the invention, means are provided for varying the cross section of the light sheet, for varying the length of the light sheet and/or for influencing the direction in which individual beam components extending within the light sheet are directed to the specimen substance. This makes it possible to adapt the geometry of the light sheet to the illumination requirements for observing one and the same specimen plane with a plurality of different objectives and, if required, to reduce shadows occurring within the observed specimen plane as a result of the illumination.Type: ApplicationFiled: November 28, 2007Publication date: September 24, 2009Inventors: Helmut Lippert, Matthias Wald, Benno Radt
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Publication number: 20070253044Abstract: A correction device for an imaging optical arrangement exhibiting a light path (1), in particular for a microscope, that exhibits at least one plane-parallel transparent plate (9), which is held in a mounting plate in the image beam path (1) and is propelable around at least one axle in a tipping and/or a swiveling motion, in order in adjust a definite parallel misalignment of the beams in the image beam path (1) by a change in the tipping situation of the plate (9). A confocal microscope with such a correction device exhibits a confocal screen (4), which illustrates a specimen mark (10), whereby the plane-parallel plate (9) is placed in front of the detector unit (2) in the light path (1), in order to center the illustration of the aperture diaphragm on the detector unit.Type: ApplicationFiled: April 12, 2007Publication date: November 1, 2007Applicant: CARL ZEISS JENA GMBHInventors: Joerg Steinert, Matthias Wald, Saskia Pergande
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Publication number: 20070253046Abstract: A correction device for an imaging optical arrangement exhibiting a light path (1), in particular for a microscope, that exhibits at least one plane-parallel transparent plate (9), which is held in a mounting plate in the image beam path (1) and is propelable around at least one axle in a tipping and/or a swiveling motion, in order in adjust a definite parallel misalignment of the beams in the image beam path (1) by a change in the tipping situation of the plate (9). A confocal microscope with such a correction device exhibits a confocal screen (4), which illustrates a specimen mark (10), whereby the plane-parallel plate (9) is placed in front of the detector unit (2) in the light path (1), in order to center the illustration of the aperture diaphragm on the detector unit.Type: ApplicationFiled: June 29, 2007Publication date: November 1, 2007Inventors: Joerg Steinert, Matthias Wald, Saskia Pergande
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Patent number: 7270431Abstract: To provide an illumination beam (5) which is essentially homogeneous in cross-section, in particular for a laser scanning microscope (15), an illumination device is used which provides an original beam which is essentially rotationally symmetric in cross-section and is incident at a converting unit which then transmits the desired illumination beam (5) and which comprises, for this purpose, an aspherical, convex mirror (1) which is more strongly curved in the area of the point of incidence of the original beam (3) than in the areas removed from the point of incidence.Type: GrantFiled: October 19, 2004Date of Patent: September 18, 2007Assignee: Carl Zeiss Jena GmbHInventors: Michael Goelles, Ralf Wolleschensky, Dieter Graefe, Matthias Wald
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Publication number: 20060012891Abstract: To provide an illumination beam (5) which is essentially homogeneous in cross-section, for a laser scanning microscope with sampling in the form of a line (15), an illumination device is used which provides an original beam which is essentially rotationally symmetric in cross-section and is incident at a converting unit which then transmits the desired illumination beam (5) and which comprises, for this purpose, an aspherical, convex mirror (1) which is more strongly curved in the area of the point of incidence of the original beam (3) than in the areas removed from the point of incidence.Type: ApplicationFiled: October 19, 2004Publication date: January 19, 2006Inventors: Michael Goelles, Ralf Wolleschensky, Dieter Graefe, Matthias Wald
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Publication number: 20060012863Abstract: To provide an illumination beam (5) which is essentially homogeneous in cross-section, for a laser scanning microscope with light distribution in the form of a point, an illumination device is used which provides an original beam which is essentially rotationally symmetric in cross-section and is incident at a converting unit which then transmits the desired illumination beam (5) and which comprises, for this purpose, an aspherical, convex mirror (1) which is more strongly curved in the area of the point of incidence of the original beam (3) than in the areas removed from the point of incidence.Type: ApplicationFiled: October 19, 2004Publication date: January 19, 2006Inventors: Michael Goelles, Ralf Wolleschensky, Dieter Graefe, Matthias Wald
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Publication number: 20060012892Abstract: A correction device for an imaging optical arrangement exhibiting a light path (1), in particular for a microscope, that exhibits at least one plane-parallel transparent plate (9), which is held in a mounting plate in the image beam path (1) and is propelable around at least one axle in a tipping and/or a swiveling motion, in order in adjust a definite parallel misalignment of the beams in the image beam path (1) by a change in the tipping situation of the plate (9). A confocal microscope with such a correction device exhibits a confocal screen (4), which illustrates a specimen mark (10), whereby the plane-parallel plate (9) is placed in front of the detector unit (2) in the light path (1), in order to center the illustration of the aperture diaphragm on the detector unit.Type: ApplicationFiled: October 19, 2004Publication date: January 19, 2006Inventors: Joerg Steinert, Matthias Wald, Saskia Pergande
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Publication number: 20060012899Abstract: To provide an illumination beam (5) which is essentially homogeneous in cross-section, in particular for a laser scanning microscope (15), an illumination device is used which provides an original beam which is essentially rotationally symmetric in cross-section and is incident at a converting unit which then transmits the desired illumination beam (5) and which comprises, for this purpose, an aspherical, convex mirror (1) which is more strongly curved in the area of the point of incidence of the original beam (3) than in the areas removed from the point of incidence.Type: ApplicationFiled: October 19, 2004Publication date: January 19, 2006Inventors: Michael Goelles, Ralf Wolleschensky, Dieter Graefe, Matthias Wald