Abstract: Disclosed are devices, systems, and methods for securing data using attribute based data access. The data may correspond to a sensory environment, and the data is secured at the device. The device secures the data by segmenting the data into number of segments and defining an access policy, further submitting the access policy to a PKG of system for generating Access Tree having attributes at different level for accessing the data. These Access Trees are securely stored on the device using IBE mechanism. Further, the data after being secured, is uploaded to a system for analysis. At the system, an access request may be received for accessing the data. The access request further includes a request attribute, whereby the system verifies if the attribute satisfies the Access Policy. If the verification is positive, an access may be provided to the data accessor for accessing the data.

Abstract: Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: A method, non-transitory computer readable medium, and pharmaceutical assessment computing device that effectively reformulates and repositions pharmaceutical molecule data. With this technology, therapeutic area data comprising a medical condition and pharmaceutical molecule data corresponding to the medical condition is obtained. The pharmaceutical molecule data comprises pharmaceutical molecule identifiers and usage data parameters with corresponding usage data values for each of the pharmaceutical molecule identifiers. Each of the usage data values is compared to a corresponding usage threshold value. Reformulation opportunities are determined for each of the pharmaceutical molecule identifiers comprising a usage data value that exceeds the corresponding usage threshold value.

Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. A first aspect of the invention relates to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titer of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titer of untreated patients increased by the double of the standard deviation of this control antibody titer.

Abstract: A method for treatment of malignant cells includes administering to the malignant cells nanoparticles and etoposide. The nanoparticles are selected from the group consisting of single wall carbon nanotubes, silver nanoparticles, gold nanoparticles and combinations thereof.

Abstract: An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second arrangement which can be configured to receive and modulate the at least one second radiation so as to provide at least one third electro-magnetic radiation. The optical cavity can further include a dispersive optical third arrangement which can be configured to receive and disperse at least one third electro-magnetic radiation so as to provide at least one fourth electro-magnetic radiation.

Abstract: The present invention provides derivatized magnetic nanoparticles, methods for making such nanoparticles, and methods for their use.

Abstract: The integrated personalized content recommendation and management system aggregates content across multiple third-party websites and applications to be presented to said user based to generate personalized content recommendations. The system utilizes a unique profile associated with a particular user to generate the personalized content recommendations, and additionally, the system may seamlessly propagate the user's profile across multiple third-party websites and applications, and build social instructions based on the user's profile. The integrated personalization content recommendation and management system and method may provide an online recommendation and social networking service that delivers to users personalized content, social and/or product recommendations derived from participating electronic mediums (e.g. web sites, applications and mobile devices).

Abstract: The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.

Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Abstract: Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.

Abstract: The present invention relates to biodegradable hydrophobic composite materials and a process for the preparation of said hydrophobic biodegradable materials from the seaweed polysaccharides through grafting reaction with vinylated monomers e.g. vinyl acetate. The said composites can be used as a substitute for synthetic ropes for varied applications including seaweed cultivation in the open sea. The results of cultivation experiments showed that ropes are suitable for cultivation of seaweeds in the sea environment, and exhibit higher biomass yield as compared to synthetic ropes. The prepared composites are very flexible and can be used for making handles for carry bags and for the preparation of biodegradable designs, bowls, pots, jars, gift items, stud caps and bracelets.

Abstract: A system and method are provided to facilitate pet owners meeting other pet owners having similar pets, and allowing the pets and their owners to mingle and socialize with one another. The system and method may be adapted for use with any species of pet. Alternative embodiments may also be adapted for facilitating runners or other fitness conscious individuals to meet and coordinate work outs with other like-minded fitness conscious individual. Still other alternative embodiments may be adapted for facilitating the coordination family or children's activities amongst a community of similarly situated families. A preferred embodiment facilitates the coordination of dog walking activities among users by communicating information about a first dog owner and his or her dog to one or more other dog owners located in the same general area as the first dog owner. Similar information about the other dog owners and their dogs is communicated to the first dog owner.

Abstract: An integrated process for the recovery of a spectrum of commercially valuable products such as agar, cellulose, lipids, pigments and a liquid rich in minerals of agricultural importance directly from fresh seaweed without employing any catalyst driven in situ chemical conversions. Also solvents used during lipid extraction were shown to be used for three cycles without affecting the yield and quality of successive products. Furthermore, this new process is highly efficient and utilizes total seaweed raw material without any leftover biomass as solid waste.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.

Abstract: A composition containing carbon black and a naturally occurring oil for use in rubber processing.

Abstract: A system for generating eccentering corrected response includes a logging tool configured to examine a material filled in an annular space to generate a tool response. The material is filled in an annular space formed by an outer conduit and an inner conduit disposed in the outer conduit. The logging tool is disposed in an inner conduit. The tool response includes scattered gamma ray photon counts distorted by a radial shift of the logging tool. The system includes a data transmission device coupled to a plurality of detectors and configured to transmit data detected by the plurality of detectors. The system also includes a computer processor linked to the data transmission device and configured to receive the tool response. The computer processor is configured to process the tool response and generate an eccentered corrected response by correcting effects of the radial shift in the tool response using eccentering correction technique.