Patents by Inventor Mehdi Azimi

Mehdi Azimi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110312718
    Abstract: A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, recombinase, DNA polymerase and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during recombinase polymerase amplification (RPA) of the target nucleic acid sequences.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Geoffrey Richard Facer, Kia Silverbrook
  • Publication number: 20110312801
    Abstract: A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the fluorophore is a lanthanide metal-ligand complex.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Kia Silverbook
  • Publication number: 20110312582
    Abstract: A test module for amplifying nucleic acid sequences, the test module having an outer casing with receptacle for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi, Geoffrey Richard Facer
  • Publication number: 20110312686
    Abstract: A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one elongate PCR chamber having a longitudinal extent much greater than its lateral dimensions, and, at least one elongate heater element for heating the nucleic acid sequences within the elongate PCR chamber, wherein, the elongate heater element extends parallel with the longitudinal extent of the PCR chamber.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Geoffrey Richard Facer, Kia Silverbrook
  • Publication number: 20110312647
    Abstract: A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having an array of hybridization chambers, each containing probes for hybridization with the target nucleic acid sequences, a temperature sensor for sensing the temperature at the array of hybridization chambers, and, a hybridization heater for heating the array of hybridization chambers, wherein during use, output from the temperature sensor is used for feedback control of the hybridization heater.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Publication number: 20110312702
    Abstract: A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi, Geoffrey Richard Facer, Alireza Moini
  • Publication number: 20110312815
    Abstract: A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for processing a fluid sample, and, a humidity sensor for sensing the humidity of an area encompassing the MST layer, wherein, the humidity sensor generates an output for humidity control of the area encompassing the MST layer.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Publication number: 20110312580
    Abstract: A lab-on-a-chip (LOC) device for amplifying nucleic acid sequences in a sample, the LOC device having a supporting substrate, a plurality of functional sections for processing the sample, one of the functional sections being a nucleic acid amplification section for amplifying nucleic acid sequences in the sample, wherein, the nucleic acid amplification section is supported on the supporting substrate and the supporting substrate defines a trench for thermally insulating the nucleic acid amplification section from one or more of the other functional sections.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Geoffrey Richard Facer, Kia Silverbrook, Mehdi Azimi
  • Publication number: 20110312572
    Abstract: A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a lysis section for lysing pathogens and leukocytes in the sample to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the pathogens and leukocytes in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the lysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Alireza Moini, Kia Silverbrook, Mehdi Azimi, Geoffrey Richard Facer
  • Publication number: 20110312563
    Abstract: A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, hybridization chambers containing the probes for detection of the targets, and a pair of the electrodes, and, at least one negative control chamber containing negative control probes that are incapable of hybridization with any nucleic acid sequences in the fluid.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi
  • Publication number: 20110311394
    Abstract: A microfluidic device having a channel having an inlet, an outlet and a meniscus anchor between the inlet and the outlet such that liquid flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, and, an actuator valve with a movable member for contacting the liquid, and an actuator for displacing the movable member from a quiescent position to an actuated position where the meniscus is extended into contact with a surface downstream of the meniscus anchor such that the liquid flow towards the outlet resumes.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Matthew Taylor Worsman, Kia Silverbrook, Mehdi Azimi
  • Publication number: 20110312641
    Abstract: A microfluidic device for detecting hybridization of probes with target nucleic acid sequences, the microfluidic device having a sample inlet for receiving a fluid sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, and, a flow-path from the sample inlet to the array, wherein, the flow-path is configured to draw the fluid sample from the sample inlet to the probes by capillary action.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi
  • Publication number: 20110312666
    Abstract: A microfluidic device having a probe for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid having a reporting fluorophore for emitting a fluorescence signal in response to an excitation light, a detection photodiode for exposure to the excitation light and the fluorescence signal, and, a trigger photodiode for exposure to the excitation light, the trigger photodiode being configured to activate the detection photodiode after the excitation light has been extinguished.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Kia Silverbrook, Alireza Moini
  • Publication number: 20110312670
    Abstract: A microfluidic test module for analyzing a sample fluid and communicating test results to an ebook reader, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the ebook reader, and, a controller for operative control of the communication interface.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Alireza Moini, Mehdi Azimi
  • Publication number: 20110312560
    Abstract: A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting sub
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi, Geoffrey Richard Facer, Alireza Moini
  • Publication number: 20110312688
    Abstract: A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein, the PCR chamber is between the heater element and the supporting substrate.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Geoffrey Richard Facer, Kia Silverbrook, Mehdi Azimi
  • Publication number: 20110312750
    Abstract: A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a plurality of reagent reservoirs containing all reagents necessary for the biochemical processing, wherein, each of the reagent reservoirs have an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biochemical liquid removes the reagent meniscus.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Publication number: 20110312779
    Abstract: An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of ejectors, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, and, bond-pads for electrically connecting the CMOS circuitry and an external microprocessor controller for operative control of the array of ejectors.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi
  • Publication number: 20110312824
    Abstract: A test module for analyzing fluid containing target nucleic acid sequences, the test module having a casing for hand-held portability, the casing having a receptacle for receiving the fluid, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, and, a waste accumulator for storage of waste material separated from the fluid, wherein, the waste accumulator has a waste reservoir and a porous element to draw the waste material into the waste reservoir by capillary action.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Mehdi Azimi, Kia Silverbrook
  • Publication number: 20110312820
    Abstract: A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, prisms positioned in the outer casing for redirecting light from the excitation light to simultaneously illuminate the probes.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 22, 2011
    Inventors: Kia Silverbrook, Mehdi Azimi