Abstract: The invention is directed to a differential gear mechanism (26) for a drug delivery device with a primary drug delivery assembly (3) and a secondary drug delivery assembly (4), wherein the primary drug delivery assembly (3) comprises a primary dose dial sleeve (17) and wherein the secondary drug delivery assembly (4) comprises a secondary drive sleeve (24). The invention is also directed to a respective drug delivery device.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), and a piston rod (30) coupled to the housing (10) and to a drive sleeve (40). Rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10). The piston rod (30) is coupled to the housing (10) via a threaded interface (16, 31) with at least two different pitches.

Abstract: The invention is directed to a drug delivery device (1) comprising a primary drug delivery assembly (3) for the delivery of a primary medicament with a primary dose setting mechanism (8) and a secondary drug delivery assembly (4) for the delivery of a secondary medicament. A selection element (13) is movable in a first and a second direction and configured such that movement of the selection element (13) in the first direction and in the second direction causes the setting of an increasing dose in the primary dose setting mechanism (8).

Abstract: A method is provided for determining a value for an electrical output of a converter of renewable energy. The method comprises obtaining a signal representing the electrical output of the converter wherein that electrical output has an initial value. The method further comprises applying a pulse signal to the signal representing the electrical output, wherein the pulse signal comprises a positive portion and a negative portion. The method further comprises obtaining a measurement of electrical power produced by the converter during application of the pulse signal, removing the pulse signal and then obtaining a measurement of electrical power produced by the converter in the absence of the pulse signal. An error value is determined from the obtained electrical power measurements and that error value is applied to the initial value to obtain a target value for the electrical output of the converter.

Abstract: A drive assembly for use in a drug delivery device is proposed, the drive assembly comprising: a housing having a proximal end and a distal end; an axis extending between the proximal end and the distal end; at least one drive member; a piston rod adapted to be driven along the axis by the drive member; an indicator adapted to provide positional information about a position of the piston rod relative to the proximal end, wherein the indicator and the piston rod are configured to convert a movement of the piston rod with respect to the housing into a rotational movement of the indicator. Additionally, a drug delivery device comprising the drive assembly is provided for.

Abstract: The present invention is directed generally to cell culture media (particularly serum free, non animal derived, and/or chemically defined media) which are useful for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells (e.g., eukaryotic cells). According to the invention, such introduction can take place in the presence of said medium. Cells containing such introduced materials can then be cultured in the medium and the effect of the introduced materials on the cells can be measured or determined. In particular, the invention allows introduction of nucleic acid molecules (e.g., vectors) into cells (particularly eukaryotic cells) and expression of proteins encoded by the nucleic acid molecules in the cells. The invention obviates the need to change the cell culture medium each time a different procedure is performed with the cells (e.g., culturing cells vs. transfecting cells).

Abstract: A method is provided for determining a value for an electrical output of a converter of renewable energy. The method comprises obtaining a signal representing the electrical output of the converter wherein that electrical output has an initial value. The method further comprises applying a pulse signal to the signal representing the electrical output, wherein the pulse signal comprises a positive portion and a negative portion. The method further comprises obtaining a measurement of electrical power produced by the converter during application of the pulse signal, removing the pulse signal and then obtaining a measurement of electrical power produced by the converter in the absence of the pulse signal. An error value is determined from the obtained electrical power measurements and that error value is applied to the initial value to obtain a target value for the electrical output of the converter.

Abstract: An electrical power generating system based on a photovoltaic cell array comprises means for monitoring the output of the array in order to determine whether the output is sufficient to sustain supply to a connected power network. The output of the array is monitored by sensing the voltage across a resistor connected across the array output. The array is connected to the network when a predetermined threshold is reached.

Abstract: A drive assembly for use in a drug delivery device is proposed, the drive assembly comprising: a housing having a proximal end and a distal end; an axis extending between the proximal end and the distal end; at least one drive member; a piston rod adapted to be driven along the axis by the drive member; an indicator adapted to provide positional information about a position of the piston rod relative to the proximal end, wherein the indicator and the piston rod are configured to convert a movement of the piston rod with respect to the housing into a rotational movement of the indicator. Additionally, a drug delivery device comprising the drive assembly is provided for.

Abstract: Dispensing apparatus comprising a housing having a first part (2) and a second part (3) together defining an interior of the housing for receiving a dispensing container, the first and second part being movable from an open position to permit insertion of said dispensing container into the interior of the housing to a closed position in which removal of said dispensing container from the interior of the housing is prevented, the dispensing apparatus further comprising a mouthpiece (4) which is removably connectable to the housing, wherein when connected to the housing the mouthpiece defines an outlet for a product dispensed, in use, from said dispensing container, and wherein when the mouthpiece is disconnected from the housing the first and second parts substantially enclose the interior to prevent access to and removal of said dispensing container received in the interior.

Abstract: A system for managing hedge funds includes a storage unit operable to store hedge fund information. The hedge fund information comprises at least one of a fund name, a fund share class, and denominated currency of a fund share class for a hedge fund. The system further includes a determination unit operable to determine, upon receiving hedge fund information, if the hedge fund information corresponds to a known hedge fund based on the received hedge fund information. The determination unit is operable to compare hedge fund information from a plurality of information sources so as to confirm whether the received hedge fund information relates to the same hedge fund.

Abstract: Dispensing apparatus comprising a housing for receiving in use a dispensing container (100) containing a product, the housing comprising an outlet through which said product, in use, is dispensed, wherein the dispensing apparatus further comprises a trigger mechanism (7) for controlling actuation of a dispensing container (100) received in the housing, the trigger mechanism (7) comprising a pivotable member (74) rotatable from a first position to a second position, wherein the dispensing apparatus further comprises lock-out means movable from a locked position, in which rotation of the pivotable member from its first position to its second position is prevented, to an unlocked position, in which the pivotable member (74) is free to rotate.