Patents by Inventor Michael A. Brown

Michael A. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11340933
    Abstract: A method and system for managing dynamic runtime information provision for a container implementing a Session Management Function (SMF) executed by an electronic device in a 3rd generation partnership project (3GPP) 5th Generation (5G) mobile network core. The method includes starting a container image load, the container image including at least a secret sub unit and an application sub unit, the application sub unit providing the SMF, determining an input source to provide a secret value for the container, the input source identified by information in the secret sub unit in the container image, and providing the secret value to a destination sub unit of the container.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: May 24, 2022
    Assignee: Telefonaktiebolaget LM Ericsson (publ)
    Inventors: James Donald Reno, Michael Brown, Akshay Rajesh Baheti, Michael Cameron
  • Patent number: 11331343
    Abstract: Chimeric poliovirus is capable of activating antigen presenting cells. The activation of the antigen presenting cells may be in vitro, ex vivo, or in vivo. The activated antigen presenting cells may be administered alone or with an antigen or vaccine. The activated antigen may be loaded in vitro or ex vivo with antigen to form antigen-loaded, activated, antigen presenting cells. These may be administered therapeutically. Therapeutic administration of antigen presenting cells may be used as an adjuvant to other therapies.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: May 17, 2022
    Assignee: Duke University
    Inventors: Smita Nair, Michael Brown, Darell Bigner, Matthias Gromeier
  • Publication number: 20220148137
    Abstract: A system and method for reflection removal of an image from a dual-pixel sensor. The image including a left view and a right view. The method including: determining a first gradient of the left view and a second gradient of the right view; determining disparity between the first gradient and the second gradient using a sum of squared differences (SSD); determining a confidence value at each pixel using the SSD; determining a weighted gradient map using the confidence values; minimizing a cost function to estimate the background layer, the cost function including the weighted gradient map, wherein the image includes the background layer added to a reflection layer; and outputting at least one of the background layer and the reflection layer.
    Type: Application
    Filed: May 26, 2020
    Publication date: May 12, 2022
    Inventors: Abhijith PUNNAPPURATH, Michael BROWN
  • Publication number: 20220142200
    Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
    Type: Application
    Filed: January 21, 2022
    Publication date: May 12, 2022
    Applicant: South Dakota State University
    Inventors: William Gibbons, Michael Brown
  • Patent number: 11325915
    Abstract: This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 10, 2022
    Assignee: The Institute of Cancer Research: Royal Cancer Hospital
    Inventors: Richard Marais, Caroline Springer, Dan Niculescu-Duvaz, Natalie Miller, Mohammed Aljarah, Alfonso Zambon, Leo Leung, Deborah Smithen, Michael Brown, Haoran Tang
  • Publication number: 20220141172
    Abstract: Verification associated with a domain name is performed using a hierarchical domain name system. A domain name system query comprising the domain name is transmitted via a network. A response to the domain name system query is received via the network. The response comprises first data. Input data is received via the network. A hash function is used to map the input data received via the network to second data. The second data comprises hashed data. A result of a verification associated with the domain name is determined based on a comparison involving the first data and the second data.
    Type: Application
    Filed: November 8, 2021
    Publication date: May 5, 2022
    Inventor: Elliott Michael BROWN
  • Publication number: 20220129836
    Abstract: A delivery system generates a pick sheet containing a plurality of SKUs based upon an order. A loaded pallet is imaged to identify the SKUs on the loaded pallet, which are compared to the order prior to the loaded pallet leaving the distribution center. The loaded pallet may be imaged while being wrapped with stretch wrap. At the point of delivery, the loaded pallet may be imaged again and analyzed to compare with the pick sheet.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 28, 2022
    Inventors: Peter Douglas Jackson, Robert Lee Martin, JR., Daniel James Thyer, Justin Michael Brown
  • Patent number: 11307129
    Abstract: Automated apparatuses for use in examining gas sorption materials are described. Devices utilize a noncontact magnetic induction heating approach for controlling the temperature of tested materials. The apparatuses can be used to generate single or multiple isotherms simultaneously. The apparatuses can examine nanogram or microgram-scale quantities of materials of interest and can do so automatically and unattended. Pressure-composition isotherms can be provided through use of disclosed apparatuses in a period of a few hours.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: April 19, 2022
    Assignee: Savannah River Nuclear Solutions, LLC
    Inventors: Simona E. Hunyadi Murph, Henry T. Sessions, Michael A. Brown
  • Patent number: 11298679
    Abstract: Multi-functional materials for use in reversible, high-capacity hydrogen separation and/or storage are described. Also described are systems incorporating the materials. The multi-functional materials combine a hydrogen-absorbing material with a high-efficiency and a non-contact energy-absorbing material in a composite nanoparticle. The non-contact energy-absorbing material include magnetic and/or plasmonic materials. The magnetic or plasmonic materials of the composite nanoparticles can provide localized heating to promote release of hydrogen from the hydrogen storage component of the composite nanoparticles.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: April 12, 2022
    Assignee: Savannah River Nuclear Solutions, LLC
    Inventors: Simona H. Murph, Kaitlin J. Lawrence, Henry T. Sessions, Michael A. Brown
  • Publication number: 20220093283
    Abstract: The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.
    Type: Application
    Filed: December 7, 2021
    Publication date: March 24, 2022
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Michael A. Brown, Jerry A. Nolen, JR., Walter F. Henning, David A. Rotsch, Sergey D. Chemerisov, Jeongseog Song
  • Publication number: 20220080495
    Abstract: The present disclosure relates to a method of forming a cast component and a method of forming a casting mold. The method is performed by connecting at least one wax gate component to a ceramic core-shell mold. The ceramic core-shell mold includes at least a first core portion, a first shell portion, and a second shell portion, wherein the first shell portion is adapted to interface with at least the second shell portion to form at least one first cavity between the core portion and the first and second shell portions. The core-shell mold may be inspected and assembled prior to connection of the wax gate component. At least a portion of the ceramic core-shell mold and the wax gate component is coated with a second ceramic material. The wax gate component is then removed to form a second cavity in fluid communication with the first cavity.
    Type: Application
    Filed: November 22, 2021
    Publication date: March 17, 2022
    Inventors: Xi Yang, Michael Cole, Michael Brown, Gregory Terrence Garay, Tingfan Pang, Brian David Przeslawski, Douglas Gerard Konitzer
  • Publication number: 20220086124
    Abstract: Data is processed using a hierarchical domain name system. A domain name system query for a first domain name is transmitted via a network. The first domain name comprises a second domain name and at least one label preceding the second domain name. The at least one label comprises data obtained based on a third domain name having been processed using a domain name modification operation. A response to the domain name system query for the first domain name is received via the network. The response comprises one or more resource records comprising information associated with the third domain name. The response to the domain name system query for the first domain name is processed. The processing of the response comprises identifying the information associated with the third domain name in the one or more resource records.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Inventor: Elliott Michael BROWN
  • Publication number: 20220040754
    Abstract: The present disclosure relates to a method of forming a cast component and a method of forming a casting mold. The method is performed by connecting at least one wax gate component to a ceramic core-shell mold. The ceramic core-shell mold includes at least a filter, first core portion, a first shell portion, and at least one first cavity between the core portion and the first shell portion. The core-shell mold may manufactured using an additive manufacturing process and may include an integrated ceramic filter. At least a portion of the ceramic core-shell mold and the wax gate component is coated with a second ceramic material. The wax gate component is then removed to form a second cavity in fluid communication with the first cavity.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Inventors: Xi Yang, Michael Cole, Michael Brown, Gregory Terrence Garay, Tingfan Pang, Brian David Przeslawski, Douglas Gerard Konitzer
  • Patent number: 11241547
    Abstract: An atomizing nozzle structured particularly for nasal therapy. Preferred embodiments include a 2-piece atomizing nozzle structured to couple with luer-locking structure carried by a syringe. Such an atomizing nozzle includes a nasal stopper and a stem. A preferred nasal stopper includes a distal tip sized for insertion into a nostril of a human child, with a proximal shield portion being structured to resist over-insertion of a discharge orifice into the nostril. A nasal stopper desirably provides a centering function to urge the discharge orifice away from a nasal wall. One operable stem is structured to couple with the stopper and desirably carries unitary thread structure at a proximal end. A second operable stem is structured as a unitary part of the nasal stopper and also desirably carries unitary thread structure at a proximal end. Certain embodiments may also include spacer structure configured to reduce a dead volume inside the atomizing nozzle.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: February 8, 2022
    Assignee: TELFLEX MEDICAL INCORPORATED
    Inventors: Marshall T. Denton, Perry W. Croll, Mark A. Christensen, Timothy R. Wolfe, J. Michael Brown
  • Patent number: 11235378
    Abstract: Integrated core-shell investment casting molds include a filament structure corresponding to a cooling hole pattern in the surface of the turbine blade, stator vane, or shroud.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: February 1, 2022
    Assignee: General Electric Company
    Inventors: Xi Yang, Michael Cole, Michael Brown, Gregory Terrence Garay, Tingfan Pang, Brian David Przeslawski, Douglas Gerard Konitzer
  • Patent number: 11235491
    Abstract: Integrated core-shell investment casting molds include a filament structure corresponding to a cooling hole pattern in the surface of the turbine blade, stator vane, or shroud.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: February 1, 2022
    Assignee: General Electric Company
    Inventors: Xi Yang, Michael Cole, Michael Brown, Gregory Terrence Garay, Tingfan Pang, Brian David Przeslawski, Douglas Gerard Konitzer
  • Publication number: 20220017516
    Abstract: The disclosure relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, Formula (I) as defined herein. Compounds according to Formula I are pharmacologically effective as lysyl oxidase (LOX) inhibitors and are believed to be useful in the treatment of, for instance, cancer.
    Type: Application
    Filed: November 15, 2019
    Publication date: January 20, 2022
    Inventors: Mohammed ALJARAH, Dan NICULESCU-DUVAZ, Leo LEUNG, Deborah SMITHEN, Michael BROWN, Lawrence Christopher DAVIES, Caroline SPRINGER
  • Publication number: 20220005581
    Abstract: A method of treatment comprises administering, via data processing hardware, to a first set of one or more users, a digital therapeutic, wherein the digital therapeutic comprises at least cognitive behavioral therapy content, administering, via the data processing hardware, to a second set of one or more users, at least one of a sham or a placebo digital therapeutic, wherein the at least one sham or placebo digital therapeutic does not comprise any cognitive behavioral therapy content, determining, via the data processing hardware, a first efficacy value associated with the digital therapeutic based on an analysis of engagement of the first set of one or more users with the digital therapeutic, determining, via the data processing hardware, a second efficacy value associated with the at least one sham or placebo digital therapeutic based on analysis of engagement of the second set of one or more users with the sham or placebo digital therapeutic, determining, via the data processing hardware, a third efficacy
    Type: Application
    Filed: July 2, 2021
    Publication date: January 6, 2022
    Inventors: Michael Brown, Timothy Campellone
  • Publication number: 20210405012
    Abstract: A system and process may be used to test water samples to measure ATP and/or estimate a microbial population, for example using an adenosine triphosphate (ATP) based assay. The system includes a device that is use in combination with single-use or disposable cartridges. The cartridge receives the water sample and is pre-loaded with one or more reagents. The device receives the cartridge and contains physical, electronic and/or mechatronic devices that interact with cartridge. One or more actions such as metering, mixing and conveying are performed automatically by elements of the device and/or cartridge. A sensor in the device measures light produced in the cartridge from a reaction with ATP in the water sample. Optionally, the cartridge also contains a pre-loaded amount of ATP, which is used to provide an internal reference or calibration measurement.
    Type: Application
    Filed: December 13, 2019
    Publication date: December 30, 2021
    Inventors: Patrick Andrew WHALEN, Derek Christopher DUNN, William DICKE, Xavier BOULERICE, David MCMULLIN, Michael BROWN
  • Patent number: D941443
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: January 18, 2022
    Inventor: Michael Brown