Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes, such as serum albumin, or portions of genes have been replaced by homologs from another animal, such as a human, to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: An electromagnetic system consists of an electric circuit comprising two solenoids wired in series, one mounted either side and proximate to a toroid. Voltage is applied across the toroid and the solenoids in a specific sequence which alters the inductance behavior of the system, resulting in an inductance gain and no mutual inductance between the toroid and the two solenoids.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: Embodiments of the invention provide for allocating loyalty rewards to a customer in advance of the customer earning the reward based at least in part on historical purchasing performance. For example, in accordance with embodiments of the invention, the customer/participant is rewarded (e.g., provided rewards points or bestowed another reward) at the onset of a year based on the previous year's purchasing behavior/program participation, and as the customer/participant transacts throughout the ensuing year the purchases/transactions are decremented against the reward.

Abstract: Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions.

Abstract: Systems and methods for providing entities in a value chain of a product or service with an integrated management system associated with an integrated database which collects information from and provides information to various entities in the value chain, including providing offers targeted to the entities in the value chain. Systems and methods are also disclosed for providing consumers with a service to consolidate e-mails.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: A method, computer program product and processor for quantitatively registering a 2D endoscopic ROI in a 3D volumetric imaging dataset. An endoscopic dataset and a volumetric imaging are registered to a common coordinate system. A 2D endoscopic ROI is generated within the endoscopic imaging dataset. A 3D surface ROI is generated within the volumetric imaging dataset corresponding to the 2D endoscopic ROI, based on a projection of the 2D endoscopic ROI to the registered common coordinate system.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: Computer memory management systems and methods are provided in which data block buffering and priority scheduling protocols are utilized in compressed memory systems to mask the latency associated with memory reorganization work following access to compressed main memory. In particular, data block buffers and priority scheduling protocols are implemented to delay and prioritize memory reorganization work to allow resources to be used for serving new memory access requests and other high priority commands.

Abstract: An electromagnetic system consists of an electric circuit comprising two solenoids wired in series, one mounted either side and proximate to a toroid. Voltage is applied across the toroid and the solenoids in a specific sequence which alters the inductance behaviour of the system, resulting in an inductance gain and no mutual inductance between the toroid and the two solenoids.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: A computer system enables a financial institution to award an account reward points when a customer remits a payment in a timely basis. Consequently, the financial institution encourages repayment of debt and recognizes good behavior through reward points every time a payment is received on-time. Each time a customer pays on-time, a credit card company may assign reward points to the customer's account for the amount of the payment. When a payment for a loan has been received in accordance with a reward policy, a number of reward points may be awarded to a customer that is dependent on a payment amount. For example, when the payment amount is at least as great as a minimum due and not greater than a balance due, setting the number of reward points to a constant multiplied by the payment amount. However, the reward points may be determined in a non-linear fashion.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.