Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Abstract: A processing machine (10) for building an object (11) from powder (12) includes a build platform (26A); a powder supply assembly (18) that deposits the powder (12) onto the build platform (26A) to form a powder layer (13); and an energy system (22) that directs an energy beam (22D) at a portion of the powder (12) on the build platform (26A) to form a portion of the object (11). The powder supply assembly (18) can include (i) a powder container (640A) that retains the powder (12); (ii) a supply outlet (639) positioned over the build platform (26A); and (ii) a flow control assembly (642) that selectively controls the flow of the powder (12) from the supply outlet (639).

Abstract: An integrated tread wear sensor and tire pressure monitoring system sensor unit container for a tire includes a tread wear sensor plug and a sensor container. The tread wear sensor plug includes a cylindrical projection extending through an opening formed in a selected tread element of the tire. A flange extends outwardly from the projection and includes a contact surface that is mounted to an innerliner of the tire. A conductive wire is disposed in the tread wear sensor plug and includes proximal ends disposed in the flange and a distal end disposed near a radially outer surface of the projection. The sensor container includes a wall extending radially from the flange of the tread wear sensor plug and terminating in a lip. A container cavity is defined by the flange, the wall, and the lip, and receives a tire pressure monitoring system sensor.

Abstract: The disclosure relates to a diffusor for a gas generator of an airbag module, comprising a substantially tubular base body with a longitudinal axis, a baffle cap axially connected to the base body at a first end of the diffusor and a connecting device configured at a second end of the diffusor opposite to the first end. At least one outflow opening is formed in an outer wall of the tubular base body such that gas can flow out of an interior of the diffusor substantially in parallel to a longitudinal axis in the direction of the first end and the second end from the diffusor. The baffle cap is free from an outflow opening. The disclosure further relates to a gas generator comprising such a diffusor, as well as an airbag module including such a gas generator. Moreover, a method for manufacturing the diffusor is also proved.

Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.

Abstract: In an assembly group comprising a cap of a tubular gas generator and a deflector element that deflects gas flowing out of at least one outflow opening of the cap to at least one discharge opening of the deflector element, a deflection surface of the deflector element is arranged radially outwardly of the outflow opening. At least two securing arms of the deflector element extend through the outflow opening and engage behind an edge defining the outflow opening on an inside in a positive connection with the cap. The cap is fixed firmly to an axial end of the tubular gas generator. Subsequently, the deflector element is slid from an outside of the cap with its securing arms through the outflow opening, the securing arms forming a positive connection with the edge of the outflow opening which fixes the deflector element firmly to the cap.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A tire sensor attachment structure is provided. The tire includes a pair of bead areas, a sidewall extending from each respective bead area to a tread, a carcass extending toroidally between each of the bead areas, and an innerliner that is disposed radially inwardly of the carcass. A sensor housing is attached to the innerliner, and defines an interior chamber. A sensor is disposed in the chamber. The tire sensor attachment structure includes a compressible body that is disposed in the chamber between the sensor and the innerliner.

Abstract: Cleaning kits for wearable devices that are simple to use, are less likely to damage wearable devices, and are effective at cleaning wearable devices. An example can include a cleaning cloth, a softening solution, a brush, and a soft gel. The cleaning cloth can be a lint-free cloth. The softening solution can be a protein emulsifier. The softening solution can be provided in an ampule or other sealed container. The brush can be formed of an elastomer, such as silicone, to reduce the chance of damage to a wearable device. The brush can have a snowball pattern to further reduce the chance of damage. The soft gel can be a hydrogel solution. The soft gel can be biodegradable and can be provided in a pouch having a tear notch.

Abstract: A method for updating a digital map. The method includes: receiving motor vehicle data signals representing respective motor vehicle data of a plurality of motor vehicles, and updating in parallel a plurality of spatially separated map segments of the digital map based on the motor vehicle data in order to update the digital map. A device, a computer program, and a machine-readable storage medium, are also described.

Abstract: Systems and methods are provided for efficiently maintaining a transaction sequence witness service to ensure that requests to read data provide consistent results across all storage nodes in a distributed system. When a storage node receives a request for a data object, the node may obtain—from transaction sequence witness service—the latest sequence number associated with the object. If the sequence number indicates the object has been modified in the period of time since the currently stored version was stored, the node can obtain the current version from persistent storage.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program identifies a first data structure having a first type. The first data structure is configured to store a set of geometries. The program further identifies a second data structure associated with the first data structure. The second data structure is configured to store modifications to the set of geometries. The program also perform a merge operation on the first data structure and the second data structure to form a third data structure.

Abstract: A method for generating a map display for vehicles. The method includes receiving vehicle sensor data; ascertaining poses of the vehicles based on the vehicle sensor data; generating subsets of the plurality of poses by combining poses of drives that have been carried out on an identical subsection of the route, a course of the respective subsection of the route being described by the vehicle sensor data assigned to the poses of every subset; generating sub-segments of the map display based on the subsets of the poses, for each subset a sub-segment being generated, and a course of the traffic lane within a sub-segment corresponding to one of the subsets being ascertained based on the poses of a subset; interpreting the sub-segments as nodes of a graph display of the map display and connecting sub-segments via edges of the graph display.

Abstract: Static and dynamic process data of a system are accessed. Thereafter, using this accessed process data, a subset of such data forming relevant data for a particular context is derived. The data is then explored using a computer-implemented process or processes to automatically get insight into information about structures, distributions and correlations of the relevant data. Rules can be generated based on the exploring of relevant data that describe data dependencies within the relevant data. These generated rules can later be used to generate synthetic data. Such synthetic data, in turn, can be used to for a variety of purposes including the training of a machine learning model while, at the same time, complying with applicable privacy and data protection laws and regulations.

Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Abstract: A method for calibrating a radar system includes generating an RF oscillator signal and distributing the RF oscillator signal to a plurality of phase shifters each providing a respective phase-shifted RF oscillator signal; receiving the phase-shifted RF oscillator signals by corresponding radar chips and radiating the phase-shifted RF oscillator signal via a first RF output channel of a first one of the radar chips; receiving a back-scattered signal by at least one RF input channel of each radar chip and generating a plurality of base-band signals by down-converting the received signals into a base band using the phase-shifted RF oscillator signals received by the corresponding radar chips; determining a phase for each base-band signal; and adjusting the phase shifts caused by the phase shifters such that the phases of the base-band signals match a predefined phase-over-antenna-position characteristic.

Abstract: Systems and methods are provided for using a distributed cache architecture with different methods to load balance requests depending upon whether a requested data item is a freely-requested item (e.g., a “hot key”). The cache may be implemented as a consistent hash ring, and most keys may be assigned to particular node based on a consistent hash. For hot key requests, the requests may be distributed among a subset of nodes rather than being assigned to a specific node using consistent hashing. When a witness service is used to ensure that cached data is fresh, verification requests for data regarding hot keys may be batched to avoid overloading the witness service with hot key requests.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives, from a client device, a percentage value for a set of points. The program further determines a triangulation based on the set of points. The program also determines an alpha value based on the triangulation and the percentage value. The program further determines an alpha shape based on the alpha value. The program also provides the client device the alpha shape.

Abstract: A method of configuring or changing a configuration of a POS terminal by at least one operator, in which an authorization of the operator by the POS terminal is established, in which after successful authorization of the at least one operator, the at least one operator carries out the configuration or change of the configuration, in which an identification feature for identification of the at least one operator is introduced into the POS terminal, in which this identification feature is used for authorizing the at least one operator. A method of associating a POS terminal with an operator, in which the POS terminal checks the integrity of the identification feature of the operator for identification of the operator, with which the POS terminal is associated.

Abstract: The invention relates to a valve bag, in particular a cross-bottom valve bag, comprising a first wall and a second wall, which are joined to each other by means of side edges or side folds and by means of bottoms and which delimit a bag interior, comprising a valve, which is arranged in one of the bottoms and via which the bag interior can be filled with a filling material, and comprising venting openings in the first and/or in the second wall for venting the bag interior. At least one channel is provided on the outside of at least one wall, which channel covers the venting openings and is formed at least by two parallel fastening strips and by a cover strip, the cover strip likewise comprising venting openings, and wherein the shortest path between the parallel fastening strips along the cover strip is longer than the shortest path along the at least one wall or the cover strip, and/or the parallel fastening strips consist of stretchable material.