Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.

Abstract: In an embodiment of the invention, analytical data may be extracted from a business intelligence (BI) system on criteria specified in metadata of a business intelligence query. Once the data is extracted from the BI system, the extracted content may be provided in the context of semantic identifiers. In an embodiment, the semantic identifiers may provide a description of the extracted content associated with the identifier. In one embodiment, the semantic identifiers may be obtained from the criteria specified in the query. In another embodiment, the semantic identifiers may be defined in and obtained from a separate enterprise service repository. In an embodiment, a proposed mapping between query elements and semantic identifiers may be suggested by a processor.

Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Abstract: A workpiece is designed for rolling stresses and includes a body having a core zone and a carbonitrided surface zone which surrounds the core zone. The workpiece body is formed of a fully hardening steel. The core zone has a bainite microstructure as its main constituent. The surface zone of the workpiece has a mixed microstructure comprising martensite and bainite and the martensite in the surface zone constitutes a proportion of at least twenty percent by volume.

Abstract: A balancing process between I/O processor groups of a non-uniform multiprocessor system enables spreading of I/O workload across multiple I/O processor groups on a group base as soon as the I/O processor group with maximum group utilization reaches a certain high limit together with other processor groups being utilized significantly lower. The additional balancing is decreased step by step again when a certain low utilization limit is reached or the workload becomes more evenly balanced between the I/O processor groups. Checking if increase or decrease of the balancing is required is done periodically, but with low frequency to not affect overall performance. The checking and balancing happens asynchronously in predefined intervals. This solves the problem that with an increasing number of I/O processors the handling of initiatives leads to increased cache traffic and contention due to shared data structures, which slows down the I/O workload handling significantly.

Abstract: Use of polyvinyllactam-polyvinyl acetate block copolymers as solubilizers for active ingredients that are sparingly soluble in water.

Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.

Abstract: The invention relates to a device for filtering of oil circulating in an internal combustion engine, comprising an oil filter adapter for detachable fastening of an exchangeable oil filter to the engine block of the internal combustion engine. The invention is characterized in that the oil filter adapter has a receptacle with an inserted pin, the receptacle having an outflow for returning the oil flowing from the exchangeable oil filter, the receptacle having a channel which leads in particular to an oil pump, and the receptacle having a drain which leads in particular to the cylinder crankcase, the pin being inserted elastically pretensioned such that during operation the pin clears the outflow and closes the channel and the drain, and, when the exchangeable oil filter is loosened from the oil filter adapter, the pin is displaced by spring force and clears the outflow, the channel, and the drain. Furthermore the invention includes a pin which is designed for use in the device according to the invention.

Abstract: A method for implementing connected input/output (I/O) hub configuration and management includes configuring a first I/O hub in wrap mode with a second I/O hub. The hubs are communicatively coupled via a wrap cable. The method further includes generating data traffic on a computing subsystem that includes the hubs. Generating traffic includes: converting, via the first hub, a request to implement a transaction into an I/O device-readable request packet and transmitting the request packet over the wrap cable; converting, via the second hub, the I/O device-readable (IODR) request packet into a system readable request and transmitting the request over a system bus; converting, via the second hub, the response to an IODR response packet, and transmitting the response packet over the wrap cable; and converting, via the first hub, the IODR response packet into a system readable response packet, and transmitting the response packet over the system bus.

Abstract: A system for implementing non-standard I/O adapters in a standardized I/O architecture, the system comprising an I/O hub communicatively coupled to an I/O bus and at least one I/O adapter, the I/O hub including logic for implementing a method, the method comprising receiving a request to perform an operation on the I/O adapter from a requester at a requester address, the I/O adapter at a destination address, determining that the request is in a format other than a format supported by the I/O bus, the I/O bus expecting a requester identifier at a first location in a header of the request, reformatting the request into the format supported by the I/O bus, the reformatting comprising storing the requester address, the destination address and an operation code at the first location in the header of the reformatted request, and sending the reformatted request to the I/O adapter.

Abstract: A system and a method for failover control comprising: maintaining a primary device table entry (DTE) in a first table activated for a first adapter in communication with a first processor node having a first root complex via a first switch assembly and maintaining a secondary DTE in standby for a second adapter in communication with a second processor node having a second root complex via a second switch assembly; maintaining a primary DTE in a second table activated for the second adapter and maintaining a secondary DTE in standby for the first adapter; and upon a failover, updating the secondary DTE in the first table as an active entry for the second adapter and forming a path to enable traffic to route from the second adapter through the second switch assembly over to the first switch assembly and up to the first root complex of the first processor node.

Abstract: A balancing process between I/O processor groups of a non-uniform multi-processor system enables spreading of I/O workload across multiple I/O processor groups on a group base as soon as the I/O processor group with maximum group utilization reaches a certain high limit together with other processor groups being utilized significantly lower. The additional balancing is decreased step by step again when a certain low utilization limit is reached or the workload becomes more evenly balanced between the I/O processor groups. Checking if increase or decrease of the balancing is required is done periodically, but with low frequency to not affect overall performance. The checking and balancing happens asynchronously in predefined intervals. This solves the problem that with an increasing number of I/O processors the handling of initiatives leads to increased cache traffic and contention due to shared data structures, which slows down the I/O workload handling significantly.

Abstract: A method and device for heating or hardening at least an axial segment of a rotationally-symmetric surface of a work piece includes rotating the work piece about its rotational axis and moving a peripheral portion of an inductor along a longitudinal profile of the axial segment of the rotating work piece with a constant spacing between the peripheral portion and the axial segment. At least a portion of the movement of the peripheral portion is composed of a first vector component in the direction of the rotational axis and a second component extending perpendicularly to the first vector component. The peripheral portion has a length in the rotational axis direction that is less the length of the axial segment in the rotational axis direction.

Abstract: In an embodiment of the invention, analytical data may be extracted from a business intelligence (BI) system on criteria specified in metadata of a business intelligence query. Once the data is extracted from the BI system, the extracted content may be provided in the context of semantic identifiers. In an embodiment, the semantic identifiers may provide a description of the extracted content associated with the identifier. In one embodiment, the semantic identifiers may be obtained from the criteria specified in the query. In another embodiment, the semantic identifiers may be defined in and obtained from a separate enterprise service repository. In an embodiment, a proposed mapping between query elements and semantic identifiers may be suggested by a processor.

Abstract: In an embodiment of the invention, analytical data may be extracted from a business intelligence (BI) system on criteria specified in metadata of a business intelligence query. Once the data is extracted from the BI system, the extracted content may be provided in the context of semantic identifiers. In an embodiment, the semantic identifiers may provide a description of the extracted content associated with the identifier. In one embodiment, the semantic identifiers may be obtained from the criteria specified in the query. In another embodiment, the semantic identifiers may be defined in and obtained from a separate enterprise service repository. In an embodiment, a proposed mapping between query elements and semantic identifiers may be suggested by a processor.

Abstract: A configuration adaptation layer (CAL) for I/O devices such as I/O adapters is provided. This configuration adaptation layer (CAL) explicitly provides a mapping between adapter functions and adapter resources in a way such that it is senseable in-band by the computer system using the adapter, e.g., by a virtual machine monitor.

Abstract: In a method for starting an internal combustion engine having at least one cylinder, an inlet and an outlet valve, and having a piston interacting with a crankshaft, and the crankshaft moving in a predetermined rotational direction during normal operation of the internal combustion engine, the piston is located in an initial position, the piston is moved into a defined starting position against a normal rotational direction of the crankshaft by means of a drive, fuel is injected, and the fuel is ignited.

Abstract: A method of providing service authorization by sending a message from a redirect server to a user terminal including an authorization token. The method includes detecting and removing the authorization token by a network gateway node from the message before forwarding the message to the user terminal.

Abstract: A brake system for a motor vehicle which simplifies the hydraulic design and avoids a vacuum prevailing over a relatively long period of time. The first hydraulic unit has a suction volume, which is connected to the suction side of the pump and which, in the event of a change in the pressure on the suction side of the pump, provides a pressure and volume equalization by means of the brake fluid stored in the suction volume, with an elastic element.

Abstract: Methods, systems, and apparatus, including computer program products, for implementing a software architecture design for a software application implementing data migration. The application is structured as multiple process components interacting with each other through service interfaces, and multiple service operations, each being implemented for a respective process component. The process components include a Product Property Management process component, a Production Model Management process component, a Business Partner Data Management process component, a Product Data Maintenance process component, an Installed Base Data Management process component, a Price Master Data Management process component, an Identity Management process component, an Engineering Change Processing process component, a Migration Data Dispatching process component, and several other process components.