Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Abstract: Surgical systems and methods for avoiding injury to an anatomical structure are disclosed. According to some aspects, an implantable device configured to emit a detectable field may be attached to the anatomical structure. A proximity sensor may be attached to a distal end of a surgical instrument and may be configured to detect the detectable field. A control unit in communication with the proximity sensor may be configured to use the proximity sensor to determine if the distal end of the surgical instrument is within a predetermined distance of the implantable device. If so, a notification such as a vibration or alarm may be provided to a user of the surgical instrument so that the user can maneuver the surgical instrument to limit or prevent contact with the anatomical structure.

Abstract: A charging server stores records corresponding to each of multiple subscriber identifiers associated with respective mobile devices. At least one record contains a counter value corresponding to one of multiple counter identifiers. The charging server receives a request from a policy server via a network, containing one of the subscriber identifirs and a session identifier. Responsive to receiving the request, the charging server determines whether the request includes any counter identifiers. When the request does not include any counter identifiers, the charging server determines whether the record corresponding to the received subscriber identifier contains any counter values. When the record includes at least one counter value, the charging server establishes a communications session with the policy server and transmits the at least one counter value to the policy server. When the record does not include any counter values, the charging server establishes a communications session with the policy server.

Abstract: According to embodiments described in the specification, a method, system and apparatus for managing communication sessions using joint storage. One of a policy server and a charging server, connected to each other via a core mobile network, stores a database containing both charging data and policy data. The other of the policy server and the charging server, rather than maintaining a distinct database, routes read and write operations to the server storing the database.

Abstract: A hydraulic component includes a piston and a cylinder with a piston receiving space in which the piston is displaceably arranged while defining a chamber, via which a pressure may be applied to a first end face of the piston, from a control chamber, via which pressure may be applied to a second end face of the piston which faces away from the first end face. A first hydraulic line and a second hydraulic line open into the chamber and a control line, which branches off from the first hydraulic line, opens into the control chamber. Due to the respective pressure ratio between the pressure in the chamber and the control chamber, the piston is displaceable from a closed position, in which the first and second hydraulic lines are fluidly decoupled, into an open position, in which the first and second hydraulic lines are fluidly connected, and vice versa.

Abstract: A charging server stores records corresponding to each of multiple subscriber identifiers associated with respective mobile devices. At least one record contains a counter value corresponding to one of multiple counter identifiers. The charging server receives a request from a policy server via a network, containing one of the subscriber identifirs and a session identifier. Responsive to receiving the request, the charging server determines whether the request includes any counter identifiers. When the request does not include any counter identifiers, the charging server determines whether the record corresponding to the received subscriber identifier contains any counter values. When the record includes at least one counter value, the charging server establishes a communications session with the policy server and transmits the at least one counter value to the policy server. When the record does not include any counter values, the charging server establishes a communications session with the policy server.

Abstract: A method of configuring or changing a configuration of a POS terminal by at least one operator, in which an authorization of the operator by the POS terminal is established, in which after successful authorization of the at least one operator, the at least one operator carries out the configuration or change of the configuration, in which an identification feature for identification of the at least one operator is introduced into the POS terminal, in which this identification feature is used for authorizing the at least one operator. A method of associating a POS terminal with an operator, in which the POS terminal checks the integrity of the identification feature of the operator for identification of the operator, with which the POS terminal is associated.

Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Abstract: A cutting tool includes a plurality of cut-off wheels which are arranged alongside one another coaxially along a common rotation axis. Each of the plurality of cut off wheels comprises a blade body which comprises a plurality of cutting segments distributed around a circumference of the blade body, each blade body defining a central cutting plane. Some of the plurality of cutting segments are configured to protrude axially out of the central cutting plane. The plurality of cutting segments are arranged so that a segment gap exists between two cutting segments arranged adjacent to one another in a direction of rotation. At least a first of the plurality of cutting segments arranged in a first axial position is configured to be larger than a second of the plurality of cutting segments arranged in a second axial position which differs from the first axial position.

Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Abstract: According to embodiments described in the specification, a method, system and apparatus for managing communication sessions using joint storage. One of a policy server and a charging server, connected to each other via a core mobile network, stores a database containing both charging data and policy data. The other of the policy server and the charging server, rather than maintaining a distinct database, routes read and write operations to the server storing the database.

Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Abstract: A lipid particle can include a cationic lipid. The cationic lipid can include one or more hydrophobic tails, which can include one or more sites of unsaturation. The sites of unsaturation can include cycloalkyl groups, e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl groups. The lipid particle is suitable for delivering an active agent.

Abstract: Surgical systems and methods for avoiding injury to an anatomical structure are disclosed. According to some aspects, an implantable device configured to emit a detectable field may be attached to the anatomical structure. A proximity sensor may be attached to a distal end of a surgical instrument and may be configured to detect the detectable field. A control unit in communication with the proximity sensor may be configured to use the proximity sensor to determine if the distal end of the surgical instrument is within a predetermined distance of the implantable device. If so, a notification such as a vibration or alarm may be provided to a user of the surgical instrument so that the user can maneuver the surgical instrument to limit or prevent contact with the anatomical structure.

Abstract: A cutting tool includes a plurality of cut-off wheels which are arranged alongside one another coaxially along a common rotation axis. Each of the plurality of cut off wheels comprises a blade body which comprises a plurality of cutting segments distributed around a circumference of the blade body, each blade body defining a central cutting plane. Some of the plurality of cutting segments are configured to protrude axially out of the central cutting plane. The plurality of cutting segments are arranged so that a segment gap exists between two cutting segments arranged adjacent to one another in a direction of rotation. At least a first of the plurality of cutting segments arranged in a first axial position is configured to be larger than a second of the plurality of cutting segments arranged in a second axial position which differs from the first axial position.

Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.

Abstract: Described is a method and an apparatus for producing cured coating films on a substrate surface. Specifically, a portable spraygun may be used to initiate radiation cure without the operative having to be protected from radiation. The spraygun comprises a supply channel for a radiation-curable coating composition, a needle, a reserve for the radiation-curable coating composition, and, optionally, a supply channel for a gas.

Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.

Abstract: This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders. Oxy149 can be delivered either locally or systemically.

Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.