Patents by Inventor Michael A. Kuhn

Michael A. Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5633585
    Abstract: The invention relates to An MR method for determining the nuclear magnetization distribution in an examination zone, in which sub-image data are acquired by means of a surface coil arrangement comprising at least two surface coils and having a locally inhomogeneous sensitivity, MR superposition images being formed from said sub-image data by weighted summing. An as artefact-free as possible reproduction of MR superposition images is achieved in that the data of at least one sub-image acquired by means of a surface coil are multiplied by a further weighting function in such a manner that sub-image areas which contain artefacts are weighted less than areas without artefacts.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: May 27, 1997
    Assignee: U.S. Philips Corporation
    Inventor: Michael Kuhn
  • Patent number: 5516864
    Abstract: This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: May 14, 1996
    Assignee: Molecular Probes, Inc.
    Inventors: Michael A. Kuhn, Richard P. Haugland
  • Patent number: 5501980
    Abstract: The indicator compounds of the present invention are substituted or unsubstituted BAPTA-type chelators that contain a benzazolyl-coumarin substructure, and the pharmaceutically acceptable non-toxic salts and esters thereof. These compounds are useful for the detection and quantification of polycationic metal ions, particularly Ca.sup.2+.The compounds of the invention have the core structure ##STR1## or the structure ##STR2## where m=2 or 3 and X can be S, O, or C(CH.sub.3).sub.2. The above core structures are optionally substituted by substituents that alter the binding affinity of the indicator, shift the spectral properties of the indicator, or act as a reactive site for the preparation of a variety of conjugates.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: March 26, 1996
    Assignee: Molecular Probes, Inc.
    Inventors: Haralambos E. Katerinopoulos, Helene Iatridou, Evangelia Foukaraki, Mohammad N. Malekzadeh, Michael A. Kuhn, Richard P. Haugland
  • Patent number: 5459276
    Abstract: The indicator compounds of the present invention are substituted or unsubstituted 5'-nitro-BAPTA chelators that contain a benzazolyl-coumarin substructure, and the pharmaceutically acceptable non-toxic salts and esters thereof. These compounds are useful for the detection and quantification of polycationic metal ions, particularly Zn.sup.2+, Pb.sup.2+, Ba.sup.2+, Cd.sup.2+, Hg.sup.2+ and La.sup.3+.The compounds of the invention have the structure: ##STR1## where m=2 or 3 and X can be S, O, or C(CH.sub.3).sub.2 ; optionally substituted by substituents that alter the binding affinity of the indicator, shift the spectral properties of the indicator, or act as a reactive site for the preparation of a variety of conjugates.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: October 17, 1995
    Assignee: Molecular Probes, Inc.
    Inventors: Michael A. Kuhn, Richard P. Haugland, Brian M. Hoyland
  • Patent number: 5453517
    Abstract: The invention relates to fluorescent and/or reactive derivatives of 1,2-bis-(2-aminophenoxyethane)-N,N,N',N'-tetraacetic acid (BAPTA) according to the formula: ##STR1## where at least one of W and X is a functional group, with or without a spacer, that terminates in an alcohol or phenol, a thiol, a haloacetamide, an alkyl halide, an amine or aniline, a carboxylic acid, an anhydride, an isocyanate, an isothiocyanate, a maleimide, or an activated ester. The BAPTA-like molecule may be further substituted, one or more times, by additional functional groups with or without spacers or by CH.sub.3, NO.sub.2, CF.sub.3, F, Cl, Br, I, or carboxylic acid derivatives or pharmaceutically acceptable salts thereof, or by indolyl or benzofuran fluorophores. The functional groups allow for subsequent covalent attachment of one or more oxygen heterocycle fluorophores (e.g. fluorescein, coumarin, rhodamine); or polymolecular assemblies (e.g.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: September 26, 1995
    Assignee: Molecular Probes, Inc.
    Inventors: Michael A. Kuhn, Richard P. Haugland
  • Patent number: 5405975
    Abstract: This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: April 11, 1995
    Assignee: Molecular Probes, Inc.
    Inventors: Michael A. Kuhn, Richard P. Haugland
  • Patent number: 5230311
    Abstract: The invention relates to a mass compensator for an internal combustion piston engine with three banks of four cylinders and a crankshaft with four crank pins on each of which operates one connecting rod of each bank of cylinders, whereby to compensate the especially second-order mass forces and moments, compensating shafts bearing balance weights are fitted which are driven in opposite directions at twice the crankshaft speed and whose axis of rotation co-ordinates to the crankshaft axis substantially meet the conditions below:y.sub.2 =-2y.sub.1 and x.sub.2 ==2x.sub.1.
    Type: Grant
    Filed: March 21, 1992
    Date of Patent: July 27, 1993
    Assignee: Audi AG
    Inventors: Michael Kuhn, Xaver Stemmer, Manfred Schindler, Walter Vilsmeier
  • Patent number: 5228292
    Abstract: An arrangement for adjusting the boost pressure in an internal-combustion engine, supercharged by an exhaust-gas turbocharger with adjustable turbine diffuser, to a predetermined desired boost-pressure value dependent on the operating point. To improve the efficiency of the internal-combustion engine in the non-steady-state mode, especially after a positive load change out of low load and speed ranges, or, after a positive load change during the non-steady-state mode, below a predetermined threshold value for the exhaust-gas counterpressure upstream of the turbine the boost pressure is regulated according to a first characteristic corresponding to the instantaneous true deviation of the actual boost-pressure value from the desired boost-pressure value. After this threshold value has been exceeded, the exhaust-gas counterpressure is regulated predetermining hypothetical control deviations for the boost-pressure control circuit according to a special characteristic.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: July 20, 1993
    Assignee: Mercedes-Benz AG
    Inventors: Horst Hanauer, Michael Kuhn
  • Patent number: 5174119
    Abstract: A process for adjusting the boost pressure in an internal-combustion engine, supercharged by an exhaust-gas turbocharger with adjustable turbine diffuser, to a predetermined desired boost-pressure value dependent on the operating point. To improve the efficiency of the internal-combustion engine in the non-steady-state mode, especially after a positive load change out of low load and speed ranges, or, after a positive load change during the non-stead-state mode, below a predetermined threshold value for the exhaust-gas counterpressure upstream of the turbine the boost pressure is regulated according to a first characteristic corresponding to the instantaneous true deviation of the actual boost-pressure value from the desired boost-pressure value. After this threshold value has been exceeded, the exhaust-gas counterpressure is regulated predetermining hypothetical control deviations for the boost-pressure control circuit according to a special characteristic.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: December 29, 1992
    Assignee: Mercedes-Benz AG
    Inventors: Horst Hanauer, Michael Kuhn
  • Patent number: 5111144
    Abstract: The invention relates to a magnetic resonance tomography method where a plurality of sequences act on an object to be examined in the presence of a steady, uniform magnetic field, each of said sequences including the generating of a magnetic rf pulse in conjunction with a first magnetic gradient field and the reading of a spin resonance signal in the presence of a second magnetic gradient field having a gradient extending perpendicularly to the gradient of the first field, an image of the nuclear magnetization distribution being reconstructed from the spin resonance signals by Fourier transformation. In order to produce a survey image therefrom in an as short as possible period of time, the object to be examined is displaced during the examination in the direction of the gradient of the first magnetic gradient field, the image of the nuclear magnetization distribution being line-wise reconstructed by way of a one-dimensional Fourier transformation of the spin resonance signal each time obtained.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: May 5, 1992
    Assignee: U.S. Philips Corp.
    Inventor: Michael Kuhn
  • Patent number: 4950308
    Abstract: The apparatus for producing a product gas from a fine-grained carbon-bearing substance during a high-pressure gasification comprises a vertical gasifier and radiative cooling device, a vertical convective cooling device through which a flow occurs from top to bottom and a connecting pipe between a head of the gasifier and radiative cooling device and a head of the convective cooling device. The gasifier and radiative cooling device comprises a pipe-like shaft, a lower cinder outlet and an upper conical connecting piece for the connecting pipe. The shaft is constructed as an equal speed flow duct, which is not equipped for feeding a foreign cooling means, but is designed so that solidification of the accompanying cinders travelling with the product gas occurs by radiative cooling.
    Type: Grant
    Filed: July 13, 1989
    Date of Patent: August 21, 1990
    Assignee: Krupp Koppers GmbH
    Inventors: Michael Lang, Gerhard Wilmer, Michael Kuhn
  • Patent number: 4895707
    Abstract: Meander-shaped exhaust gas ducts pass through a soot burn-off filter made of porous ceramic filter material. Catalytically coated blind ducts branch from each of the outer bends to receive and combust solid combustion residues from the exhaust gases. The residual gases produced in the blind ducts by the oxidation of the combustion residues pass through the filter material into adjacent discharge ducts and are transported from there to the outside of the filter. In this way the exhaust gas ducts remain largely free of solid combustion residues, display no clogging phenomena and therefore keep the exhaust gas backpressure low. This improves the starting behavior of an engine, achieves more favorable warm-up behavior and has a positive influence upon the response behavior of an exhaust gas turbocharger.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: January 23, 1990
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventor: Michael Kuhn
  • Patent number: 4836161
    Abstract: The invention relates to a direct fuel injection method for a diesel engine in which a preset quantity of fuel is introduced into a combustion space via a fuel injection nozzle in a preinjection and in a main injection which is separate from the preinjection. To achieve a short ignition delay with lowest possible specific fuel consumption during this process, the beginning of the preinjection occurs within the range of 10.degree.-16.degree. or of 20.degree.-30.degree. crank angle before top dead center, depending on speed, and the beginning of the main injection occurs within the range of 2.degree. after top dead center to 15.degree. before top dead center, the interval between the end of the preinjection and the beginning of the main injection being within the range of 3.degree. to 14.degree. or of 3.degree. to 26.degree. crank angle before top dead center and the preinjection quantity is 10% to 20% or 1% to 5% of the quantity of fuel preset in each case, depending on load.
    Type: Grant
    Filed: October 8, 1987
    Date of Patent: June 6, 1989
    Assignee: Daimler-Benz Aktiengesellschaft
    Inventors: Jorg Abthoff, Manfred Fortnagel, Ludwig Fricker, Immanuel Kutschera, Michael Kramer, Michael Kuhn
  • Patent number: 4713756
    Abstract: A nonvolatile memory storage device for a programmable controller to provide an archival back-up for user programs with the use of a battery or other alternate back-up power source. The device can be attached to the programmable controller using a frangible tampering indicator that will break on the removable of the device from the programmable controller.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: December 15, 1987
    Assignee: Westinghouse Electric Corp.
    Inventors: Ralph E. Mackiewicz, Michael A. Kuhn
  • Patent number: 4445229
    Abstract: In a device for adjusting a movable electro-acoustic sound transducer, an optical duct is connected to the sound transducer which only allows an object, such as a display table or a data display unit, to be viewed completely in one specific position. This position is unambiguously reproducible and so is the position of the sound transducer or microphone relative to the mouth of the speaker. The optical duct may comprise diaphragms or a tube, possibly with intermediate walls, or a phase amplitude grating.The object may be a display unit and the device further comprises a device for generating variable data on the display. If used for speaker identification, the variable data generator projects consecutive instructions on the display so that, the speech recognition process is controlled automatically. The speaker to be identified is then required to keep his mouth in the correct position relative to the microphone.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: April 24, 1984
    Assignee: U.S. Philips Corporation
    Inventors: Manfred Tasto, Michael Kuhn, Herbert Piotrowski, Horst Tomaschewski, Rudolf Geppert, Hermann Ney
  • Patent number: 4344031
    Abstract: The characteristic values are obtained from the signal to be verified, e.g. in the case of a voice signal the total energy in the individual frequency spectrum ranges, and these characteristic values are quantified. The frequency with which the individual partial ranges of the quantified characteristic values occur is found during a sampling phase, and these frequencies are stored. In the test phase, the signal is analyzed in the same way and the stored frequencies of the partial ranges into which the characteristic values of the signal to be verified have fallen are multiplied and compared with a threshold. In an arrangement for implementing the method, there is a characteristic store with a store address for a multi-digit binary number for each partial range of each characteristic.
    Type: Grant
    Filed: May 14, 1980
    Date of Patent: August 10, 1982
    Assignee: U.S. Philips Corporation
    Inventors: Michael Kuhn, Ernst Bunge