Abstract: A method of determining a physical location for an address. The method includes receiving from a first global positioning system on a vehicle a first set of global positioning data indicative of a vehicle location. The method may also receive from a second global positioning system on a portable electronic device a second set of global positioning data indicative of a portable electronic device location. The method may also receive a set of location metadata associated with a picture. The method determines a residence location from the first set of global positioning data, the second set of global positioning data, or the set of location metadata. The method then associates the physical location to the address.

Abstract: The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

Abstract: A method for removing one or more objects or materials from a body lumen includes delivering a tube and an expandable device to the body lumen to a position proximal to the one or more objects or materials. The expandable device is positioned with a lumen of the tube, and the expandable device includes a lumen extending from a distal portion to a proximal portion. The method further includes proximally retracting the tube such that the expandable device remains in the position proximal to the one or more objects or materials, distally advancing the expandable device such that the distal portion of the expandable device at least partially surrounds the one or more objects or materials, at least partially closing a distal end of the expandable device, and moving the expandable device proximally to remove the expandable device and the one or more objects or materials from the lumen.

Abstract: A fire suppressing insulation. This insulation will create a barrier that blocks a fire to protect a structure from damage and will assist in suppressing the fire. Also, a fire suppression system including two walls, such as an interior wall and an exterior wall or two interior walls. The walls are spaced apart from each other by a divider to define an interior volume. At least a portion of the interior volume includes fire suppressing insulation that will form a fire suppressing intumescent barrier between the walls when exposed to the heat of a fire.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present disclosure provides a tissue debridement device and describes an example treatment for ANP using the tissue debridement device. The tissue debridement device has a sheath, a distal tip, and a plurality of rotating tines coupled to the distal tip and the sheath. The distal tip can be adjusted to be closer or further from the sheath to change a diameter of the rotating tines, thereby changing a cutting diameter of the tissue debridement device.

Abstract: A recoil device is provided for a gun having a barrel with a breech. The device includes a breech nut, a brake assembly, a pneumatic spring and a counter-recoil buffer. The breech nut has first and second adjacent sides. The brake assembly includes a brake cylinder that mounts to the breech nut on the first side. The pneumatic spring mounts to the breech nut on the second side. The counter-recoil buffer attaches to the pneumatic spring. The brake cylinder and the pneumatic spring internally push fluids for recoil absorption and return in response to firing the gun.

Abstract: The present disclosure provides methods, devices, and systems that utilize dental appliance etch templates prior to or during dental treatment. One dental appliance etch template includes a removable shell having one or more cavities formed therein, where the one or more cavities are shaped to receive teeth of a patient, and the shell includes a well, the well including a wafer, where the wafer includes etch material to etch a tooth of the patient.

Abstract: Systems and methods of the present disclosure include at least one building component detection sensor device configured to be deployed within (or proximate to) a building comprised of a plurality of building components. The at least one building component detection sensor device is configured to detect data relating to at least one building component of the plurality of building components. In addition, a building component property determination system includes a processor configured to execute instructions stored in memory to determine one or more properties of the at least one building component based at least in part on the data detected by the at least one building component detection sensor device.

Abstract: This disclosure relates to cardiogenic mesoderm formation regulators and methods of use thereof, e.g., generating a multipotent cardiovascular progenitor cell by overexpressing Id1, Id2, Id3, Id4, Evx1, and/or Grrp1 in a stem cell.

Abstract: An improved door barricade system for use during an emergency situation, having a pivoting locking arm which drops into a floor hole to lock a barricade in place using a single motion egress system to unlock and open a door simultaneously.

Abstract: The present invention relates to a user digital journey validation method comprising the steps of: connecting, by a fully distributed blockchain computer system, a trust network comprising: a plurality of user nodes; a plurality of trusted party nodes; a visitor node corresponding to a visitor to a digital service; and a plurality of links, the user nodes corresponding to users, the trusted party nodes corresponding to trusted parties, the visitor node being the most recent node in the trust network, the links being the connections between nodes; rating, by the trust network, the visitor node, the rating being a visitor trust score; recording, via a digital journey mapping system, a digital journey of the visitor; analysing, by the AI system, the digital journey of the visitor; detecting, by the AI system, bot-like behaviour associated with the visitor node or the user nodes; assigning, by the AI system, a warning flag to the visitor node or the user if the visitor node or user node has associated bot-like be

Abstract: A helmet accessory mounting system includes a mounting device configured to couple to an outer surface of a side of a helmet. The mounting device includes a plurality of mounting locations configured to removeably couple to at least one accessory. A plurality of the plurality of mounting locations each includes an electrical node. A power supply is coupled to the mounting device. An electrical supply line electrically couples the power supply to each of the electrical nodes and the electrical supply line is contained at least partially within the mounting device.

Abstract: A system for dispensing flame retardant foam on the exterior of a structure. The structure has an opening that enables distribution of flame retardant foam onto the roof. The system includes a foam distribution system having a foam expansion chamber and a roof plenum for delivery through the roof opening. Foam solution and compressed air are combined in a conduit and supplied to the foam expansion chamber. The structure may have at least one wall. In that case, the system may have a wall plenum for delivery of flame retardant foam from the foam expansion chamber through a first wall-associated opening. Each such wall will have an opening associated with the wall that enables distribution of flame retardant foam onto that wall.

Abstract: Provided is a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. Also provided is pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: The invention provides a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: A system may include a router that may receive a plurality of data packets from one or more devices that communicatively couples to the router. The system may also include at least one processor that identifies an identity of a device based on a data packet received by the router from the device, generate an insurance policy that includes the device in response to identifying the identity of the device, and sends a notification indicative of the insurance policy to a computing device in response to generating the insurance policy.

Abstract: The present disclosure relates to a hardened power and optical connection system for use with hybrid cables. The hardened power and optical connection system includes electrical pin and socket contacts for providing power connections, and ferrules for providing optical connections. The hardened power and optical connection system has an integrated fiber alignment provided through a mating relationship between a plug and a socket.

Abstract: Techniques are generally described for fusing sensor data of different modalities using a transformer. In various examples, first sensor data may be received from a first sensor and second sensor data may be received from a second sensor. A first feature representation of the first sensor data may be generated using a first machine learning model and a second feature representation of the second sensor data may be generated using a second machine learning model. In some examples, a modified first feature representation of the first sensor data may be generated based at least in part on a self-attention mechanism of a transformer encoder. The modified first feature representation may be generated based at least in part on the first feature representation and the second feature representation. A computer vision task may be performed using the modified first feature representation.

Abstract: A cannulation device is adapted to gain access to the patient's common bile duct. In some instances, the cannulation device includes a first guidewire lumen extending through an elongate shaft and terminating at a first oblique guidewire port, and a second guidewire lumen extending through the elongate shaft and terminating at a second oblique guidewire port. In some instances, the cannulation device includes an inflatable balloon that is inflatable from a collapsed configuration to an expanded configuration in which the inflatable balloon is adapted to occlude the patient's pancreatic duct. In some instances, the cannulation device includes an expandable element that is expandable from a collapsed configuration in which the expandable element is disposed within the guidewire lumen and an extended configuration in which a portion of the expandable element extends distally from a guidewire port.