Abstract: This invention reveals an uncured pneumatic tire which is comprised of a generally toroidal-shaped supporting carcass with an outer circumferential tread, two spaced beads, at least one ply extending from bead to bead, sidewalls extending radially from and connecting said tread to said beads, a sealant layer which is disposed inwardly from the supporting carcass, and an innerliner which is disposed inwardly from the sealant layer, wherein said circumferential tread is adapted to be ground-contacting, and wherein the sealant layer is comprised of polyisobutylene or a butyl rubber, wherein the polyisobutylene or the butyl rubber has a number average molecular weight which is within the range of 30,000 to 100,000.

Abstract: Systems and methods for improving machine learning systems used to model topics on a plurality of calls are described herein. In an embodiment, a server computer receives plurality of digitally stored call transcripts that have been prepared from digitally recorded voice calls. The server computer uses a topic model of an artificial intelligence machine learning system, the topic model modeling words of a call as a function of one or more word distributions for each topic of a plurality of topics, to generate an output of the topic model which identifies the plurality of topics represented in the plurality of call transcripts. The server computer computes, for a particular topic of the plurality of topics a first value representing a vocabulary of the particular topic and a second value representing a consistency of the particular topic in two more call transcripts of the plurality of call transcripts which include the particular topic.

Abstract: A spray head adapted for connection to a supply of fluid. The head includes a body to receive the supply of fluid and a number of conical mixing volumes, in fluid connection with the body and supply of fluid, each conical mixing volume having an outlet. Each conical mixing volume includes at least one first inlet for a flow of fluid into the conical mixing volume at an angle to a conical axis thereof, and at least one second inlet for a flow of fluid into the conical mixing volume substantially parallel to the conical axis. There is a valve disposed upstream of the conical mixing volumes, the valve adapted to divide and vary the supply of fluid flow between the at least one first inlet and the at least one second inlet, which in turn varies the output of the fluid from the outlet of the conical mixing volumes.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1?-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.

Abstract: The present disclosure provides methods, devices, and systems that utilize dental appliance etch templates prior to or during dental treatment. One dental appliance etch template includes a removable shell having one or more cavities formed therein, where the one or more cavities are shaped to receive teeth of a patient, and the shell includes a well, the well including a wafer, where the wafer includes etch material to etch a tooth of the patient.

Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

Abstract: Embodiments described herein relate to current interrupt devices (CIDs) for electrochemical cells that use a thermal trigger (e.g., shape memory and/or bi-metallic materials) to open an electrical circuit just prior to a thermal runaway or during short-circuit event to prevent catastrophic failure of the electrochemical cell. Embodiments include CIDs comprising a housing, a bus bar coupled to the housing, and a thermal trigger operably coupled to the bus bar. In some embodiments, the bus bar can include an engineered fracture site. In some embodiments, the thermal trigger is dimensioned and configured to deform at a predetermined temperature to break the bus bar at the engineered fracture site. In some embodiments, a portion of the bus bar travels about a hinge, opening the electrical circuit and preventing overcharging, thermal runaway, and/or other catastrophic failure events.

Abstract: Embodiments described herein relate generally to a current interrupt device (CID) including a frangible bulb that is configured to be thermally triggered. In some embodiments, the CID includes a breaking contact electrically coupled to a fixed contact and held in electrical contact by the frangible bulb. In some embodiments, the frangible bulb is configured to break at a temperature threshold. In some embodiments, the breaking contact is configured to bend, rotate and/or otherwise deform about a hinge point in order to become electrically disconnected from the fixed contact when the frangible bulb breaks. In some embodiments, opening the electrical circuit between the breaking contact and the fixed contact may prevent overcharging, overvoltage conditions, overcurrent conditions, thermal runaway, and/or other catastrophic failure events.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.

Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion.

Abstract: An electrical shut-off device (10) is provided and includes a housing (11), first and second inputs (12, 13) and an output disposed on the housing, a transmission/reception (T/R) module (14) coupled to the first input, an input device (15) coupled to the second input, an electrical device coupled to the output and a processor (20). The processor is in signal communication with the T/R module, the input device and the electrical device via the first and second inputs and the output, respectively. The processor is configured to issue an instruction via the T/R module and to take an action relative to the electrical device responsive to a signal being received by the T/R module and to take an additional action in accordance with an actuation state of the input device.

Abstract: A helmet accessory mounting system includes a mounting device configured to couple to an outer surface of a side of a helmet. The mounting device includes a plurality of mounting locations configured to removeably couple to at least one accessory. A plurality of the plurality of mounting locations each includes an electrical node. A power supply is coupled to the mounting device. An electrical supply line electrically couples the power supply to each of the electrical nodes and the electrical supply line is contained at least partially within the mounting device.

Abstract: The invention provides a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: The present disclosure relates to a fiber alignment device including a guide feature defining a fiber alignment groove. The fiber alignment device also includes a fiber engagement component defining a reference surface arrangement and elastic cantilever arms for pressing optical fibers into the fiber alignment groove. First portions of the guide feature engage the reference surface arrangement. Second portions of the guide feature engage the cantilever arms to flex the cantilever arms to a staged position.

Abstract: A tool for performing diagnostics on a fire detection system includes an induction coil which includes two halves that may be selectively opened and closed to surround a wire in the system and sense current through the wire. A diagnostic module and a conduit provide communication of data of the sensed current between the induction coil and the diagnostic module. The diagnostic module is configured to decode the data to interpret communications sent through the wire.

Abstract: Embodiments described herein relate to systems and stacks of multiple electrochemical cells. An electrochemical cell stack includes a plurality of electrochemical cells connected in series in a single pouch. Each electrochemical cell of the plurality of electrochemical cells includes an anode disposed on an anode current collector, a cathode disposed on a cathode current collector, and a separator disposed between the anode and the cathode. The anode current collector includes an anode tab and the cathode current collector includes a cathode tab. In some embodiments, a first electrochemical cell of the plurality of electrochemical cells can be connected in series to a second electrochemical cell of the plurality of electrochemical cells by electronically coupling the cathode tab of the first electrochemical cell to the anode tab of the second electrochemical cell.

Abstract: Provided is a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. Also provided is pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: A quad-shield coaxial cable includes an insulator portion configured to encircle an inner conductor portion, an inner conductive foil portion configured to encircle the insulator portion, an inner braided shield portion configured to encircle the inner conductive foil layer portion, an outer braided shield portion configured to encircle the inner braided shield portion, an outer conductive foil portion configured to encircle the outer braided shield portion, and a jacket portion configured to encircle the outer conductive foil portion.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.