Patents by Inventor Michael A. Ramsey

Michael A. Ramsey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Apparatus for Releasably Connecting a Cable with a Tool
    Publication number: 20160053556
    Abstract: An apparatus for releasably connecting a cable with a tool that has an outer cone. The outer cone has a lower portion and an upper portion. A weak point is located between the lower portion and upper portion. The apparatus also includes an inner cone configured to fit within the outer cone.
    Type: Application
    Filed: August 20, 2014
    Publication date: February 25, 2016
    Inventors: Ricardo Vanegas, Robert Michael Ramsey, L. Michael McKee, Montie W. Morrison
  • NANOFLUIDIC DEVICES FOR THE RAPID MAPPING OF WHOLE GENOMES AND RELATED SYSTEMS AND METHODS OF ANALYSIS
    Publication number: 20160047778
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Inventors: John Michael Ramsey, Laurent Menard
  • Pressure driven microfluidic injection for chemical separations
    Patent number: 9255905
    Abstract: Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: February 9, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, Erin Anne Redman, John Michael Ramsey
  • Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
    Patent number: 9255288
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 9, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • Miniature charged particle trap with elongated trapping region for mass spectrometry
    Patent number: 9252005
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: February 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: J. Michael Ramsey, Kevin Schultze
  • NANOFLUIDIC DEVICES FOR THE RAPID MAPPING OF WHOLE GENOMES AND RELATED SYSTEMS AND METHODS OF ANALYSIS
    Publication number: 20160024569
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 28, 2016
    Inventors: John Michael Ramsey, Laurent Menard
  • Computer implemented methods and apparatus for feed-based case management
    Patent number: 9235614
    Abstract: Techniques for providing feed-based case management on an online social network. A user interface that includes a publisher and an information feed is provided. Information associated with a record is received and the record is updated in a database system. A feed item associated with the database system update is generated and provided in the information feed. The feed item includes one or more actionable selections providing a reference to the publisher. Selection of one of the one or more actionable selections causes the publisher to be operable to receive further information associated with the record. The record is capable of being updated based on the further information. In some implementations, the record is a case and the user interface serves as a single interface for all interactions required in solving the case.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: January 12, 2016
    Assignee: salesforce.com, inc.
    Inventors: Scott D. Beechuk, Orjan N. Kjellberg, Larry P. G. Robinson, Michael Ramsey, Arvind Krishnan, Jyoti M. Khubchandani, Jill Blue Lin, Mustafa O. Al-Alami, Jason A. Ellis, Christopher A. Myers, Vahn K. Phan, Chitra Gulabrani
  • Providing a timeline control in a multi-tenant database environment
    Patent number: 9230224
    Abstract: A system and method for providing a timeline control in a multi-tenant database system. In one embodiment, a method includes determining a plurality of entitlement processes and milestones that are to be enforced, where each entitlement process includes one or more actions, and where each action is associated with a corresponding milestone. The method further includes displaying a timeline control window that shows one or more milestones for an entitlement process, and updating the timeline control window as the status of the entitlement process changes.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 5, 2016
    Assignee: salesforce.com, inc.
    Inventors: Michael Ramsey, Marco S. Casalaina, Arvind Krishnan, Jason A. Ellis
  • MASS SPECTROMETRY SYSTEMS WITH CONVECTIVE FLOW OF BUFFER GAS FOR ENHANCED SIGNALS AND RELATED METHODS
    Publication number: 20150364315
    Abstract: Mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where P2<P1 which generates gas flow through an unsealed, sealed or partially sealed ion trap and enhances detected signal relative to when P2=P1.
    Type: Application
    Filed: June 9, 2015
    Publication date: December 17, 2015
    Inventors: John Michael Ramsey, Kevin Philip Schultze, Bruno Jean-Bernard Coupier
  • INTEGRATED SAMPLE PROCESSING FOR ELECTROSPRAY IONIZATION DEVICES
    Publication number: 20150340219
    Abstract: Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
    Type: Application
    Filed: June 5, 2013
    Publication date: November 26, 2015
    Inventors: John Scott Mellors, John Michael Ramsey, Nicholas George Batz
  • Methods, systems and devices for forming nanochannels
    Patent number: 9139426
    Abstract: Methods of forming at least one nanochannel include: (a) providing a substrate having a thick single or a thick multi-layer overlayer; (b) milling at least one channel through the overlayer into the substrate; then (c) removing the overlayer; and (d) forming at least one nanochannel in the substrate having an average width and depth dimension that is less than about 10 nm in response to the milling and removing steps.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: September 22, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard, Valeri Gorbounov
  • Microfluidic Devices, Solid Supports for Reagents and Related Methods
    Publication number: 20150211048
    Abstract: A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid support via a labile reagent/support bond such that the reagent is configured to be cleaved from the support via a cleaving operation.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 30, 2015
    Inventors: John Michael Ramsey, William Henley, Emily Oblath
  • METHODS AND SYSTEMS FOR NETWORK SWITCH CONFIGURATION FOR A MODULAR COMPONENT CARRYING ONE OR MORE INFORMATION HANDLING SYSTEMS
    Publication number: 20150160690
    Abstract: A method may include, receiving, by a controller integral to a chassis, a user request to apply a switch configuration. The method may also include communicating from the controller to a remote access controller (RAC) integral to at least one module disposed in a plurality of slots of the chassis an indication that a user has requested application of a switch configuration. The method may further include receiving at the controller, in response to the indication, a request to download a switch configuration file from the controller to the RAC. The method may additionally include transferring from the controller, in response to the request to download the switch configuration file, the switch configuration file to the RAC such that the RAC applies parameters set forth in the switch configuration file in order to configure an in-band switch associated with the module comprising the RAC.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 11, 2015
    Applicant: Dell Products L.P.
    Inventors: Carl W. Kagy, Christopher Abella Poblete, Scott Michael Ramsey, Wayne Robert Weilnau, JR.
  • PREDICTIVE INTELLIGENCE FOR SERVICE AND SUPPORT
    Publication number: 20150142720
    Abstract: Embodiments regard predictive intelligence for service and support. An embodiment of a method includes receiving at an interface for a database system data entered in one or more data fields regarding service of a first case for a first client, the data being received from the first client or from an agent entering data regarding the first case; automatically comparing by the database system the data for the first case with data for other cases stored in a data store of the database system; identifying by the database system one or more similar cases based on the comparison of data; automatically generating by a predictive intelligence algorithm applied by the database system one or more predictive actions for the first case based on the identified one or more similar cases; and transmitting data regarding the one or more predictive actions to the first client or agent.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Inventors: Scott D. Beechuk, Michael Ramsey, Arvind Krishnan
  • MINIATURE CHARGED PARTICLE TRAP WITH ELONGATED TRAPPING REGION FOR MASS SPECTROMETRY
    Publication number: 20150122990
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.
    Type: Application
    Filed: August 11, 2014
    Publication date: May 7, 2015
    Inventors: J. Michael Ramsey, Kevin Schultze
  • Microchips with integrated multiple electrospray ionization emitters and related methods, systems and devices
    Patent number: 9006648
    Abstract: Microchips which are particularly suitable for use with a mass spectrometer include a microchip body with at least one fluid channel formed into the microchip body and at least two flat monolithic closely spaced integrated ESI (electrospray ionization) emitters defined by shaped projections formed to extend from one side of the microchip body, a respective one being in fluid communication with a fluid channel. Related systems and methods are also described.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: April 14, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Andrew Chambers
  • DEVICES WITH FLUIDIC NANOFUNNELS, ASSOCIATED METHODS, FABRICATION AND ANALYSIS SYSTEMS
    Publication number: 20140360877
    Abstract: Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length, with width and depth dimensions that both vary over its length and forming (e.g., milling) at least one nanochannel into the planar substrate at an interface adjacent the narrow end of the nanofunnel.
    Type: Application
    Filed: February 7, 2013
    Publication date: December 11, 2014
    Inventors: John Michael Ramsey, Laurent Menard, Jinsheng Zhou, Michael Rubinstein, Sergey Panyukov
  • Miniature charged particle trap with elongated trapping region for mass spectrometry
    Patent number: 8878127
    Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 4, 2014
    Assignee: The University of North Carolina of Chapel Hill
    Inventors: J. Michael Ramsey, Kevin Schultze
  • NANOFLUIDIC DEVICES FOR THE RAPID MAPPING OF WHOLE GENOMES AND RELATED SYSTEMS AND METHODS OF ANALYSIS
    Publication number: 20140272958
    Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: John Michael Ramsey, Laurent Menard
  • MICROSCALE MASS SPECTROMETRY SYSTEMS, DEVICES AND RELATED METHODS
    Publication number: 20140263999
    Abstract: Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The stack assembly has a perimeter that bounds an area that is between about 0.01 mm2 to about 25 cm2 and the stack assembly has a thickness that is between about 0.1 mm to about 25 mm.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventor: John Michael Ramsey