Abstract: An apparatus configured as a three-dimensional (3D) printer is disclosed. The apparatus includes a print head assembly, which includes a print head and a nozzle plate, the nozzle plate configured to dispense droplets of liquid provided from the print head. The apparatus includes a build bed configured to receive at least some of the droplets from the nozzle plate, and a service station. The service station includes a spittoon assembly configured to receive at least some of the droplets from the nozzle plate, a vacuum knife assembly configured to remove at least one of: debris, or at least some of the droplets from a surface of the nozzle plate, and a non-contact wash assembly comprising a plurality of weirs configured to upwell a washing fluid and immersively receive the nozzle plate in the washing fluid.

Abstract: An apparatus configured as a three-dimensional (3D) printer is disclosed. The apparatus includes a print head assembly, which includes a print head and a nozzle plate, the nozzle plate configured to dispense droplets of liquid provided from the print head. The apparatus includes a build bed configured to receive at least some of the droplets from the nozzle plate, and a service station. The service station includes a spittoon assembly configured to receive at least some of the droplets from the nozzle plate, a vacuum knife assembly configured to remove at least one of: debris, or at least some of the droplets from a surface of the nozzle plate, and a non-contact wash assembly comprising a plurality of weirs configured to upwell a washing fluid and immersively receive the nozzle plate in the washing fluid.

Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.

Abstract: An absolute transmission accessory for a spectrometer. One example spectrometer system includes a base plate, a light source configured to transmit light, and an interferometer mounted to the base plate. The interferometer receives the light from the light source and output modulated light. The spectrometer system includes a first optical element configured to receive the modulated light and direct the modulated light, and a second optical element configured to receive the modulated light and focus the modulated light to a sample compartment. The spectrometer system includes a detector compartment including one or more detectors, the detector compartment configured to receive light from the sample compartment. The spectrometer system includes a sample holder coupled to the base plate. The modulated light is directed to the sample holder, and light exiting the sample holder is directed through the sample compartment and to the detector compartment via the second optical element.

Abstract: A circuit includes a controller. A driving signal source is coupled to the controller. A first digital output line is coupled between the controller and the analog load. The first digital output line is configured to carry a first digital signal. A second digital output line is coupled between the controller and the driving signal source. The second digital output line is configured to carry a second digital signal. The controller is configured to reproduce a target output signal defined by data from the driving source. The reproduced target output signal is generated by controlling a combination of the first digital signal and the second digital signal, as an output in the analog load.

Abstract: An implant assembly includes a housing configured to store components that generate mechanically synced electrical stimulation, a first electrode positioned on an inferior surface of the housing, and a second electrode positioned on a superior surface of the housing, the components including a force activated piezogenerator electrically connected to a impedance matched rectifying circuit, wherein the piezogenerator transduces a mechanical load to an electrical signal that is passed through the impedance matched rectifying circuit and delivered through the first and second electrode to a healing site when an anatomical force is applied to the first and second electrode that make contact with two bony surfaces.

Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.

Abstract: A pneumatic conveying system for conveying bulk material, the system comprising: an adjustable pneumatic gas flow connected to a pipeline, the pipeline being suitable for conveying bulk material; a measurement device for measuring the variability of particle velocity of a bulk material being conveyed through the pipeline; and a control apparatus, operatively connected to the adjustable pneumatic gas flow and the measurement device; wherein in use, the measurement device outputs the variability of velocity data to the control apparatus. The control apparatus analyses the variability of velocity data, and regulates the rate of the pneumatic gas flow based on the analysis of the variability of velocity data.

Abstract: An absolute transmission accessory for a spectrometer. One example spectrometer system includes a base plate, a light source configured to transmit light, and an interferometer mounted to the base plate. The interferometer receives the light from the light source and output modulated light. The spectrometer system includes a first optical element configured to receive the modulated light and direct the modulated light, and a second optical element configured to receive the modulated light and focus the modulated light to a sample compartment. The spectrometer system includes a detector compartment including one or more detectors, the detector compartment configured to receive light from the sample compartment. The spectrometer system includes a sample holder coupled to the base plate. The modulated light is directed to the sample holder, and light exiting the sample holder is directed through the sample compartment and to the detector compartment via the second optical element.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: Systems, methods and computer program products for automatically ingesting and filing documents in a database having a plurality of file locations. An electronic file having one or more documents is received. For each document in the received file, text data is identified and used to generate a plurality of suggested file locations for the received documents. Machine learning systems may be used to enhance the accuracy of suggested file locations.

Abstract: Systems, methods and computer program products for automatically ingesting and filing documents in a database having a plurality of file locations. An electronic file having one or more documents is received. For each document in the received file, text data is identified and used to generate a plurality of suggested file locations for the received documents. Machine learning systems may be used to enhance the accuracy of suggested file locations.

Abstract: Methods, systems and computer program products for organizing and displaying in real-time data related to a plurality of documents. A plurality of documents and a plurality of entity identifiers are stored in a relational database storage. Each entity identifier has an entity type selected from a plurality of entity types. A plurality of entity associations between the plurality of entity identifiers and the plurality of documents are stored in a non-relational database storage. Each entity association defines a relationship between one or more entity identifiers and a selected document in the plurality of documents. A plurality of file icons are displayed in a display interface. The plurality of file icons includes active icons corresponding to a selection of the plurality of documents where the selection is determined by querying the non-relational database storage using at least one currently-selected entity identifier.

Abstract: An automatic packaging machine is provided and comprises a plurality of in-feed conveyors for separately conveying contents. The conveyors are at different heights. The machine includes means for placing the contents into a packaging article, or placing the packaging article around the contents, with the contents in a vertically stacked configuration.

Abstract: A wraparound sleeving system is provided and comprises a sleeving machine having a conveyor for transporting packaging sleeves. The packaging sleeves comprise one or more apertures for receiving a portion of one or more respective products. The sleeving machine comprises a folder for folding the sleeve so as to wrap a portion of said sleeve over or around a portion of said product after said portion of said product is received in said aperture.

Abstract: Methods and systems for sharing electronic documents are described herein. The example method includes storing the electronic documents in a relational database storage; storing entity identifiers in the relational database storage, each entity identifier representing an entity type; recording in a non-relational database storage associations between the electronic documents and at least one entity identifier, each association comprising a relationship between a set of electronic documents and the at least one entity identifier; associating a delegate account with the at least one entity identifier; and based on an association recorded in the non-relational database storage for the at least one entity identifier, granting the delegate account a subset of document management functions available for the set of documents.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.

Abstract: Systems and methods are disclosed that cause a transient exchange ratio between digital assets at a kiosk, together with a countdown timer or other indication of how much time remains within which the ratio applies. If a transaction proceeds a voucher may be dispensed to confirm it. If a transaction participant using the kiosk is not yet vetted, the transaction is nevertheless deemed inchoate, and a prolonged vetting begins.

Abstract: Methods and systems for sharing electronic documents are described herein. The example method includes storing the electronic documents in a relational database storage; storing entity identifiers in the relational database storage, each entity identifier representing an entity type; recording in a non-relational database storage associations between the electronic documents and at least one entity identifier, each association comprising a relationship between a set of electronic documents and the at least one entity identifier; associating a delegate account with the at least one entity identifier; and based on an association recorded in the non-relational database storage for the at least one entity identifier, granting the delegate account a subset of document management functions available for the set of documents.