Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.

Abstract: A pneumatic conveying system for conveying bulk material, the system comprising: an adjustable pneumatic gas flow connected to a pipeline, the pipeline being suitable for conveying bulk material; a measurement device for measuring the variability of particle velocity of a bulk material being conveyed through the pipeline; and a control apparatus, operatively connected to the adjustable pneumatic gas flow and the measurement device; wherein in use, the measurement device outputs the variability of velocity data to the control apparatus. The control apparatus analyses the variability of velocity data, and regulates the rate of the pneumatic gas flow based on the analysis of the variability of velocity data.

Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: An absolute transmission accessory for a spectrometer. One example spectrometer system includes a base plate, a light source configured to transmit light, and an interferometer mounted to the base plate. The interferometer receives the light from the light source and output modulated light. The spectrometer system includes a first optical element configured to receive the modulated light and direct the modulated light, and a second optical element configured to receive the modulated light and focus the modulated light to a sample compartment. The spectrometer system includes a detector compartment including one or more detectors, the detector compartment configured to receive light from the sample compartment. The spectrometer system includes a sample holder coupled to the base plate. The modulated light is directed to the sample holder, and light exiting the sample holder is directed through the sample compartment and to the detector compartment via the second optical element.

Abstract: A composition is disclosed that comprises 3,3,3-trifluoropropene (1243zf), 1,1,1-trifluoropropane (263fb), vinyl chloride monomer (CH2?CHCl), and at least one of 1,1,1-trifluoroethane (143a), dichlorodifluoromethane (12), 1-chloro-1-fluoroethylene (1131a), 1-chloro-2-fluoroethylene (1131), 1,1-difluoroethane (152a), 1-chloro-2-fluoroethane (151), 1-chloro-1-fluoroethane (151a), 3-chloro-1,1,1-trifluoropropane (253fb), 1,1,1,2-tetrafluoropropane (254eb), 1,3,3,3,-tetrafluoropropane (254fb), 1,1,1,2-tetrafluoroethane (134a), 1,1,2,2,2-pentafluoropropene (1225zc), 1,3,3,3-tetrafluoropropene (1234ze), 3-chloro-3,3,-difluoropropene (1242zf), dichlorofluoropropene (1241), 1,1,3-trichloropropene (1240za), 1,1,1,3-tetrachloropropane (250fb), tetrachloroethylene (1110), chloromethane (40), 2-chloro-3,3,3-trifluoropropene (1233xf), 1-chloro-3,3,3-trifluoro-1-propene (1233zd), chlorodifluoropropene (1242), 2-chloro-1,1,1-trifluoropropane (253db), 1,2-dichloro-3,3,3-trifluoropropene (1223xd), dichlorodifluoropropene (123

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: A bacterium of the class Clostridia comprising a heterologous nucleic acid molecule encoding at least one antigen, wherein the bacterium is capable of expressing the antigen in an intracellular compartment of the bacterium during anaerobic cell growth, and wherein at least one antigen is an infectious agent antigen or a tumour antigen.

Abstract: An event can be analyzed for association with a security violation. Characters or other values of event data (e.g., command-line text) associated with the event can be provided sequentially to a trained representation mapping to determine respective representation vectors. Respective indicators can be determined by applying the vectors to a trained classifer. A token in the event data can be located based on the indicators. The event's can be determined to be associated with a security violation based on the token satisfying a token-security criterion. The representation mapping can be trained by adjusting model parameters so the trained representation predicts, based on a character of training command-line text, an immediately following character in the training command-line text. The classifier can be determined based on the trained representation mapping and classification training data indicating whether respective portions of training event data are associated with security violations.

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized back-bone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having bio-medical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

Abstract: Systems, methods and computer program products for automatically ingesting and filing documents in a database having a plurality of file locations. An electronic file having one or more documents is received. For each document in the received file, text data is identified and used to generate a plurality of suggested file locations for the received documents. Machine learning systems may be used to enhance the accuracy of suggested file locations.

Abstract: A machine includes a motor; and a transmission to drive a knife plate. The knife plate includes a plurality of knife blades. The machine further includes a die plate. The knife plate and the die plate interface at a cutting edge of the knife plate. The machine cuts feed material from larger sized pieces to smaller pieces by forcing the material through the die plate and cutting it with the knife plate.

Abstract: A shredder blade assembly is disclosed having a rotor configured to be mounted on a rotating shaft, the rotor having opposing faces with a plurality of angled knife receptacles and a plurality of knife inserts mounted within the plurality of knife receptacles. Each knife insert has two opposing faces and each opposing face comprises three cutting edges such that each knife insert has six cutting edges. Only one of the cutting edges is exposed at an outer peripheral edge of the shredder blade assembly during use. The knife inserts are configured to be removed, rotated (and flipped as needed), and re-mounted within the plurality of knife receptacles to expose another of the cutting edges at the outer peripheral edge of the shredder blade assembly. The knife insert may be triangular and mounted to expose one vertex to create a plurality of tooth/hook projections.

Abstract: Systems, methods and computer program products for automatically ingesting and filing documents in a database having a plurality of file locations. An electronic file having one or more documents is received. For each document in the received file, text data is identified and used to generate a plurality of suggested file locations for the received documents. Machine learning systems may be used to enhance the accuracy of suggested file locations.

Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: The present disclosure relates generally to fluorinated glucosamine analogs and uses thereof, including analogs of N-acetyl glucosamine fluorinated at 4- and/or 6-position(s) and derivatives of xylose at anomeric position for the treatment of a neurological disease, such as multiple sclerosis; inflammation; cancer; central nervous system injury; or conditions associated with up-regulation of an extracellular matrix, such as chondroitin sulfate proteoglycans.

Abstract: Methods, systems and computer program products for organizing and displaying in real-time data related to a plurality of documents. A plurality of documents and a plurality of entity identifiers are stored in a relational database storage. Each entity identifier has an entity type selected from a plurality of entity types. A plurality of entity associations between the plurality of entity identifiers and the plurality of documents are stored in a non-relational database storage. Each entity association defines a relationship between one or more entity identifiers and a selected document in the plurality of documents. A plurality of file icons are displayed in a display interface. The plurality of file icons includes active icons corresponding to a selection of the plurality of documents where the selection is determined by querying the non-relational database storage using at least one currently-selected entity identifier.

Abstract: Event vectors can be determined for respective events based on respective command-line records and a trained representation mapping. Respective coordinate vectors can be determined, each having fewer elements than the respective event vector. Respective representations of at least some of the events can be presented via an electronic display at the respective coordinate vectors. A selection of a first representation can be received via a user interface. The events can be clustered based on the event vectors. A first cluster can be selected based on the selection. An indication of a tag can be received via the user interface. Each event of the first cluster can be associated with the tag. Some examples include transmitting a security command to cause a monitored computing device associated with an event in the first cluster to perform a mitigation action.