Abstract: The present invention is directed to a guitar pick or plectrum for use with a stringed musical instrument and which is constructed with generally two or three veneers which are adhered to each other such that each veneer is cross grain to each adjacently adhered veneer. In other embodiments, the tip portion of the plectrum has a gauge less than the grip portion of the plectrum.

Abstract: The present invention is directed to a capo for use with a stringed musical instrument and which is engaged from the bottom portion of the neck of the musical instrument. The capo has a generally L-shaped frame connected to a lever and a pincher configured so that pressure applied to the lever causes the pincher to move toward the lever, allowing the space between the pincher and free end portion of the frame to receive the neck of the musical instrument. The exterior of the frame is configured to received interchangeable inlays, and the free end portion of the frame is configured to receive changeable neck pads.

Abstract: An infusion assembly is provided. Such an infusion assembly includes a first infusion body and a first nozzle operably engaged with the first infusion body. A first plunger is configured to translate longitudinally within the first infusion body for dispensing a first substance out of the first infusion body through the first nozzle. The plunger has a translating member and a stopper piston separable and removable from the translating member. Once separated, the stopper piston is capable of receiving a second nozzle of a second infusion body such that the first substance, along with a second substance in the second infusion body, are capable of being sequentially administered to a target site. An associated method and kit are also provided.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: A system, method, and apparatus for fuel cell utilizing hydrogen from reforming propane fuel include a propane fuel reformer, controlling operating parameters of O2/C ratio, pressure, and catalyst temperature, and a high temperature proton exchange membrane fuel cell (HT-PEMFC) controlling operating parameters of pressure and temperature. For mobile application, the system includes a 3D printed reformer for generation of hydrogen rich gas.

Abstract: The present invention is directed to a capo for use with a stringed musical instrument and which is engaged from the bottom portion of the neck of the musical instrument. The capo has a generally L-shaped frame connected to a lever and a pincher configured so that pressure applied to the lever causes the pincher to move toward the lever, allowing the space between the pincher and free end portion of the frame to receive the neck of the musical instrument. The exterior of the frame is configured to received interchangeable inlays, and the free end portion of the frame is configured to receive changeable neck pads.

Abstract: A bus seat for use in a bus comprises a base having a generally rectangular shape when viewed from a bottom. The bus seat further comprises a cushioning material arranged over a top and front portion of the base. The bus seat further comprises a cover material having a fastener with a first end and a second end attached thereto. The first end of the fastener is attached to the cover material while the second end of the fastener is connected to a predetermined portion of the base on a bottom surface thereof.

Abstract: The present invention is directed to a capo for use with a stringed musical instrument and which is engaged from the bottom portion of the neck of the musical instrument. The capo has a generally L-shaped frame connected to a lever and a pincher configured so that pressure applied to the lever causes the pincher to move toward the lever, allowing the space between the pincher and free end portion of the frame to receive the neck of the musical instrument. The exterior of the frame is configured to received interchangeable inlays, and the free end portion of the frame is configured to receive changeable neck pads.

Abstract: Embodiments of the present technology relate to systems and methods for operating a plurality of energy consuming devices. An example system for operating a plurality of energy consuming devices may comprise at least one device driver, comprising a database layer interface and a device layer interface, operating at least one device controller coupled to a plurality of energy consuming devices, the at least one device driver configured to poll each of the plurality of energy consuming devices for at least one of sensor data and output settings; a database for storing the at least one of sensor data and output settings for each of the plurality of energy consuming devices; and a processor coupled to the at least one device driver configured to compare the at least one of sensor data and output settings to criteria selected by a user.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, in duce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: A system for operating a plurality of energy consuming devices is provided. The system includes a database storing at least one device driver. The at least one device driver is for operating at least one device controller. At least one of the device drivers includes a database layer interface and a device layer interface. The system also includes a network interface coupling the database with a network. The network is coupled to the at least one device controller, and the database is adapted to transmit the device layer interface over the network to the at least one device controller. The at least one device controller controls a first energy consuming device of the plurality of energy consuming devices. A method for operating a plurality of energy consuming devices is provided that includes storing in a database at least one device driver.

Abstract: A system for operating a plurality of energy consuming devices is provided that includes a plurality of device drivers coupled to respective device controllers. Each device controller is associated with a corresponding one of the energy consuming devices, and each device controller includes at least one sensor and is adapted to modulate an output setting of the corresponding energy consuming device. The system also includes a processor coupled to the plurality of device drivers and adapted to cause each of the plurality of device drivers to periodically receive data from the respective one of the device controllers. The system further includes a display interface coupled to the processor and to a display. The display interface is adapted to transmit data to the display. A non-transitory computer readable medium having recorded thereon a program is provided. An apparatus for analyzing data from a plurality of energy consuming devices is provided.

Abstract: The present invention is directed to a capo for use with a stringed musical instrument and which is engaged from the bottom portion of the neck of the musical instrument. The capo has a generally L-shaped frame connected to a lever and a pincher configured so that pressure applied to the lever causes the pincher to move toward the lever, allowing the space between the pincher and free end portion of the frame to receive the neck of the musical instrument. The exterior of the frame is configured to received interchangeable inlays, and the free end portion of the frame is configured to receive changeable neck pads.

Abstract: An articulable elbow spacer includes a humeral component, an ulnar component, and a tie. The humeral component includes a proximal end having a rod for insertion into a humeral canal and a distal end including a first joint member, the first joint member including antibiotic cement and one or more tunnels. The ulnar component includes a proximal end including a second joint member, the second joint member including antibiotic cement and including one or more tunnels, and configured to receive the first joint member and a distal end having a rod for insertion into an ulnar canal. The tie is configured to link the humeral component to the ulnar component and is configured for insertion into the one or more tunnels of the first joint member and the one or more tunnels of the second joint member.

Abstract: A shredder blade assembly is disclosed having a rotor configured to be mounted on a rotating shaft, the rotor having opposing faces with a plurality of angled knife receptacles and a plurality of knife inserts mounted within the plurality of knife receptacles. Each knife insert has two opposing faces and each opposing face comprises three cutting edges such that each knife insert has six cutting edges. Only one of the cutting edges is exposed at an outer peripheral edge of the shredder blade assembly during use. The knife inserts are configured to be removed, rotated (and flipped as needed), and re-mounted within the plurality of knife receptacles to expose another of the cutting edges at the outer peripheral edge of the shredder blade assembly. The knife insert may be triangular and mounted to expose one vertex to create a plurality of tooth/hook projections.