Patents by Inventor Michael Brand

Michael Brand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080183468
    Abstract: Outputs of an automatic probabilistic event detection system, such as a fact extraction system, a speech-to-text engine or an automatic character recognition system, are matched with comparable results produced manually or by a different system. This comparison allows statistical modeling of the run-time behavior of the event detection system. This model can subsequently be used to give supplemental or replacement data for an output sequence of the system. In particular, the model can effectively calibrate the system for use with data of a particular statistical nature.
    Type: Application
    Filed: March 31, 2008
    Publication date: July 31, 2008
    Inventor: Michael Brand
  • Publication number: 20070213535
    Abstract: The present invention provides a process for purifying carbostyril derivatives such as 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone and 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone and aripiprazole by passing a solution of the material in an organic solvent through a suitable absorbing material.
    Type: Application
    Filed: March 7, 2007
    Publication date: September 13, 2007
    Applicant: Chemagis Ltd.
    Inventors: Michael Brand, Irina Gribun, Oded Arad, Joseph Kaspi
  • Publication number: 20070213365
    Abstract: Novel crystalline forms I, II, III, IV, V, VI, VII, VIII, IX, and X of montelukast ammonium salts are provided, and novel methods of making these forms are disclosed.
    Type: Application
    Filed: February 21, 2007
    Publication date: September 13, 2007
    Applicant: Chemagis Ltd.
    Inventors: Itai Adin, Zvicka Deutsch, Michael Brand, Moty Shookrun, Oded Arad, Joseph Kaspi
  • Publication number: 20070208177
    Abstract: The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.
    Type: Application
    Filed: February 1, 2007
    Publication date: September 6, 2007
    Applicant: Chemagis Ltd.
    Inventors: Yanling Wang, Yuang Wang, Michael Brand, Joseph Kaspi
  • Publication number: 20070208013
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Application
    Filed: June 3, 2005
    Publication date: September 6, 2007
    Applicant: BAYER PHARMACEUTICALS CORPORATION
    Inventors: Julie Dixon, Catherine Brennan, Karl Miranda, Brent Chandler, Barton Phillips, Jianmei Fan, Michael Brands, Andrea Mcclure, Benjamin Jones, Wenlang Fu, Donald Bierer, Steven Magnuson, Harold Kluender
  • Publication number: 20070208178
    Abstract: The present invention provides a process for preparing highly pure montelukast and salts thereof by reacting the side-chain precursor 1-(mercaptomethyl)-cyclopropaneacetic acid with 2-(2-(3S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxypropyl)phenyl-2-propanol in a solvent mixture containing a base.
    Type: Application
    Filed: February 27, 2007
    Publication date: September 6, 2007
    Applicant: Chemagis Ltd.
    Inventors: Michael Brand, Moty Shookrun, Oded Arad, Joseph Kaspi
  • Publication number: 20070149782
    Abstract: The present invention relates to methods of preparing a highly pure crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone, which is a chemical intermediate useful in the preparation of Aripiprazole thereof in high quality and yield, and provides data that characterizes the crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-(1H)-quinolinone.
    Type: Application
    Filed: December 23, 2005
    Publication date: June 28, 2007
    Inventors: Michael Brand, Moty Shookrun, Irina Gribun, Itai Adin, Carmen Iustain, Oleg Braverman, Natalia Udis, Oded Arad, Joseph Kaspi
  • Publication number: 20070117817
    Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
    Type: Application
    Filed: October 8, 2004
    Publication date: May 24, 2007
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Julie Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yin, Yuanwei Chen, Jianqing Chen, Brian Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin Hentemann, Ann-Marie Bullion
  • Publication number: 20060276525
    Abstract: Processes are disclosed for preparing Telmisartan form A, which is free-flowing and which does not contain electrostatic charge and is thus industrially process-able. The free-flowing Telmisartan form A is prepared by crystallization from a polar organic solvent e.g., DMSO, DMF, DMA, NMP, or water and is suitable for use in pharmaceutical compositions. A process is also disclosed for preparing highly-pure Telmisartan form A by precipitation from aqueous solutions.
    Type: Application
    Filed: May 17, 2006
    Publication date: December 7, 2006
    Inventors: Itai Adin, Carmen Iustain, Michael Brand, Ada Salman, Alexander Weisman
  • Publication number: 20060264491
    Abstract: The present invention provides an intermediate and a process for preparing Telmisartan, which overcomes the drawbacks of conventional methods and produces Telmisartan in high purity and yield.
    Type: Application
    Filed: June 8, 2006
    Publication date: November 23, 2006
    Applicant: CHEMAGIS LTD.
    Inventors: Michael Brand, Ada Salman, Yael Gafni, Michal Noiman, Alex Weisman, Joseph Kaspi
  • Publication number: 20060223820
    Abstract: Provided are novel crystalline carboxylic acid salts of aripiprazole, methods of using such salts, and processes for producing such salts.
    Type: Application
    Filed: March 21, 2006
    Publication date: October 5, 2006
    Applicant: CHEMAGIS LTD.
    Inventors: Michael Brand, Moti Shookrun, Irina Gribun, Itai Adin, Carmen Iustain, Oded Arad, Joseph Kaspi
  • Publication number: 20060183753
    Abstract: The present invention relates to the use of 2,5-diamidoindole derivatives for the preparation of medicaments for treating urological disorders in humans and/or animals.
    Type: Application
    Filed: December 6, 2003
    Publication date: August 17, 2006
    Applicant: Bayer HealthCare AG
    Inventors: Jens Erguden, Thomas Krahn, Christian Schroder, Johannes Stasch, Stefan Weigand, Hanno Wild, Michael Brands, Stehan Siegel, Dirk Heimbach, Jorg Keldenich, Masaomi Tajimi, Hiroko Takagi
  • Publication number: 20060148866
    Abstract: A novel process is provided for producing pramipexole base or its optical isomeric mixture as defined hereinabove i.e. (R,S)-2-amino-6-propyl-4,5,6,7-tetrahydrobenzothiazole avoiding the use of borane tetrahydrofuran complex and using a more convenient reducing agent like sodium triacetoxyborohydride instead. The provided process comprises reacting the starting material (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole or its optical isomeric mixture as defined hereinabove i.e. (R,S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole with propionaldehyde in an organic solvent to obtain the respective enamine, which is subsequently reduced in situ, optionally without isolation, to obtain pramipexole or its optical isomeric mixture as defined hereinabove i.e. (R,S)-2-amino-6-propyl-4,5,6,7-tetrahydrobenzothiazole, and the acid addition salts thereof.
    Type: Application
    Filed: December 13, 2005
    Publication date: July 6, 2006
    Applicant: Chemagis Ltd.
    Inventors: Guangxin Xia, Yifeng Nian, Tiema Yan, Jin Suo, Michael Brand, Oded Arad
  • Publication number: 20060122201
    Abstract: The invention relates to uracil-thioethers, pharmaceutical compositions containing said compounds and to a method for the production thereof. The invention also relates to the use of said substances in the treatment of diseases in humans and animals.
    Type: Application
    Filed: February 14, 2003
    Publication date: June 8, 2006
    Inventors: Niels Svenstrup, Alexander Kuhl, Dietmar Flubacher, Michael Brands, Kerstin Ehlert, Christoph Ladel, Michael Ottneder, Jorg Keldenich, Marcus Bauser
  • Patent number: 7045544
    Abstract: The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: May 16, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Jens-Kerim Ergüden, Thomas Krahn, Christian Schröder, Johannes-Peter Stasch, Stefan Weigand, Hanno Wild, Michael Brands
  • Publication number: 20060100224
    Abstract: The invention relates to piperidine ouracil and a method for the production thereof in addition to the use thereof in the production of medicaments for treating and/or in the prophylaxis of diseases, especially bacterial diseases.
    Type: Application
    Filed: February 13, 2003
    Publication date: May 11, 2006
    Inventors: Niels Svenstrup, Alexander Kuhl, Dietmar Flubacher, Michael Brands, Kerstin Ehlert, Christoph Ladel, Michael Otteneder, Jorg Keldenich
  • Publication number: 20060079689
    Abstract: The present invention provides several improved processes for preparing aripiprazole, wherein the first step comprising reacting 7-HQ with a 1,4-disubstituted-butane in biphasic reaction mixture or in a single phase solvent to obtain a 7-(4-halobutoxy)-3,4-dihydro-(1H)-quinolinone (7-HBQ) and the second step comprising reacting the 7-HBQ and 1-(2,3-dichlorophenyl)piperazine or an acid addition salt thereof in a biphasic reaction medium containing water and a water-immiscible solvent to obtain aripiprazole. Also provided are methods of purifying the 7-HBQs and aripiprazole.
    Type: Application
    Filed: October 11, 2005
    Publication date: April 13, 2006
    Inventors: Vladimir Naddaka, Michael Brand, Guy Davidi, Eyal Klopfer, Irina Gribun, Oded Arad, Joseph Kaspi
  • Publication number: 20060069263
    Abstract: A process is disclosed for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole, which comprises reacting (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole with a borane reagent in the presence of suitable organic solvent to yield (S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole base, which may be converted to an acid addition salt thereof. The process provided herein can be easily, conveniently and inexpensively scaled-up.
    Type: Application
    Filed: September 23, 2005
    Publication date: March 30, 2006
    Inventors: Irina Gribun, Ada Salman, Meital Shiffer, Moty Shookrun, Michael Brand, Oded Arad, Joseph Kaspi
  • Publication number: 20060069125
    Abstract: The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.
    Type: Application
    Filed: September 27, 2005
    Publication date: March 30, 2006
    Inventors: Oded Arad, Lior Zelikovitch, Mohammed Alnabari, Michael Brand, Irina Gribun, Ada Salman, Meital Shiffer, Moty Shookrun, Orna Kurlat, Moshe Bentolila, Joseph Kaspi
  • Publication number: 20060063927
    Abstract: The present invention provides herein a two-step process for preparing pharmaceutically pure quetiapine and salts thereof by obtaining the starting material 11-chloro-dibenzo-thiazepine followed by reacting the 11-chloro-dibenzo-thiazepine with 1-(2-hydroxyethoxy)ethylpiperazine, or its salt, in the presence of an inorganic or organic base in an organic solvent or in a two-phase solvent system. The present invention provides also a novel, one-pot reaction process for preparing pharmaceutically pure quetiapine and salts thereof. The two processes provided herein can be easily, conveniently and inexpensively scaled-up.
    Type: Application
    Filed: September 20, 2005
    Publication date: March 23, 2006
    Inventors: Olga Etlin, Michael Brand, Julia Ditkovich, Guy Davidi, Moty Shookrun, Oded Arad, Joseph Kaspi