Abstract: This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.

Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

Abstract: The invention relates to a drive system and to a method for monitoring a hydrostatic drive (1). The hydrostatic drive (1) has at least one hydrostatic piston engine (2) on which a control unit (6, 6?), which controls the hydrostatic piston engine (2, 2?), is arranged, wherein the control unit (6, 6?) is connected to a central control device (13), which controls the drive system (1), via a first interface (14). Control signals for controlling the drive system (1) can be transmitted using the first interface (14). The central control device (13) is additionally connected to the control unit (6) via a second interface (26, 26?), and a switch-off signal can be transmitted from the control unit (6, 6?) to the central control device (13) and/or from the central control device (13) to the control unit (6, 6?) using the second interface (26, 26?).

Abstract: This invention relates to novel compounds (I) and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.

Abstract: A method for automatically providing a plurality of additional database query terms to a user is provided. The method comprises receiving a query term from a user, receiving a plurality of characters from the user in addition to the query term, and selecting a set of records from a database based on the query term, wherein the database comprises records, and the records comprise text translated from audio. The method also determines a plurality of additional query terms based on the plurality of characters, and, for at least one of the plurality of additional query terms, processes at least a portion of the set of records to determine a relevance of the additional query term. Finally, the method includes displaying at least one of the plurality of additional query terms to the user for selection, the display based on the relevance of the at least one of the plurality of additional query terms.

Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.

Abstract: A computer system coupled to a database is configured to receive a database query, and evaluate a set of records from a database based on the database query. The database comprises a plurality of records, and each record comprises text translated from audio. The system then determines a plurality of measurement terms based on the database query, and processes at least a portion of the text of at least one record of the database to determine a quality of the database query based on the occurrences of the measurement terms within the portion of text, and performs an action based on the quality of the database query.

Abstract: The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.

Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

Abstract: The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.

Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.

Abstract: The invention relates to an arrangement for the non-contact defined movement of at least one magnetic body, free to move in at least one dimension. A simple arrangement of this type, taking up a reduced volume, of universal application, for both positioning and orientation and also for energy generation and transmission, can be achieved, by means of arranging the body with a magnetic moment in the primary magnetic field of at least one permanent magnet which moves in a defined manner, said body having a secondary magnetic field extending from the body, aligned with the primary magnetic field. At least one magnetic field sensor is provided to record the secondary magnetic field in any position of the body.

Abstract: The present invention provides a process for preparing highly pure montelukast and salts thereof by reacting the side-chain precursor 1-(mercaptomethyl)-cyclopropaneacetic acid with 2-(2-(3S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxypropyl)phenyl-2-propanol in a solvent mixture containing a base.

Abstract: A computer-implemented method for processing a plurality of data items includes defining a set of one or more categories having a corresponding set of conditions that associate the data items with the categories. A sub-categorization request, requesting to divide a category from among the categories into lower-level categories, is accepted from a user. The data items associated with the category are processed responsively to the sub-categorization request, so as to automatically suggest the lower-level categories. The automatically-suggested lower-level categories are presented to the user, and direction with respect to the automatically-suggested lower-level categories is accepted from the user. A hierarchical structure representing the categories is constructed responsively to the direction, by dividing the category into the lower-level categories. Output based on the hierarchical structure is presented to the user.

Abstract: The present invention is directed to a process of preparing montelukast or a salt thereof with minimal amounts of impurities, such as a dehydration impurity (compound (VI)) or a cyclic ether impurity (compound (VIII)).

Abstract: Outputs of an automatic probabilistic event detection system, such as a fact extraction system, a speech-to-text engine or an automatic character recognition system, are matched with comparable results produced manually or by a different system. This comparison allows statistical modeling of the run-time behavior of the event detection system. This model can subsequently be used to give supplemental or replacement data for an output sequence of the system. In particular, the model can effectively calibrate the system for use with data of a particular statistical nature.

Abstract: The present invention provides a process for purifying carbostyril derivatives such as 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone and 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone and aripiprazole by passing a solution of the material in an organic solvent through a suitable absorbing material.

Abstract: Novel crystalline forms I, II, III, IV, V, VI, VII, VIII, IX, and X of montelukast ammonium salts are provided, and novel methods of making these forms are disclosed.

Abstract: The present invention provides a process for preparing highly pure montelukast and salts thereof by reacting the side-chain precursor 1-(mercaptomethyl)-cyclopropaneacetic acid with 2-(2-(3S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxypropyl)phenyl-2-propanol in a solvent mixture containing a base.