Abstract: The invention relates to a processing apparatus for packaging machines having at least one upper processing unit for processing upper package sides and at least one lower processing unit for processing lower package sides, and having a common adjustment axle for the processing units along which the processing units are adjustable manually or by means of a drive in an adjustment direction that extends in parallel with a direction of transport of the packaging machine.

Abstract: The present invention relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity. The invention further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer. The present invention also encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer.

Abstract: Described herein are methods and systems to generate and display interactive graphical user interfaces that receive data inputs from users while emulating a chat session. A server retrieves a set of prompts associated with an electronic form; displays, within a webpage, a first element corresponding to a prompt and a second element having at least one input element configured to receive an input from a user interacting with the webpage. When the user interacts with an input element, the server relocates the first element and dynamically revises the second element by relocating the second element and displaying inputted values received from the user interacting with the at least one input element of the second element. The server then displays a third element comprising next prompts of the electronic form.

Abstract: A device implementing a system for sharing groups of files within a messaging application includes a processor configured to provide, within the messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant. The processor is further configured to, responsive to receiving a selection of the user interface element: transmit, to a server, a request to store the at least one file in association with a shared storage area, and to transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area.

Abstract: The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease.

Abstract: The present disclosure relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity. The disclosure further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer. The disclosure finally encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer.

Abstract: Monoclonal antibody that specifically binds IL-1RAcP, or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616 The monoclonal antibody is characterized in that it inhibits IL-1RAcP induced NFkB activity, useful in treatment of IL-1RAcP

Abstract: A device implementing a system for sharing groups of files within a messaging application includes a processor configured to provide, within the messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant. The processor is further configured to, responsive to receiving a selection of the user interface element: transmit, to a server, a request to store the at least one file in association with a shared storage area, and to transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area.

Abstract: The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease.

Abstract: Methods are disclosed herein for increasing retinal ganglion cell survival in a subject in need thereof. These methods include selecting a subject in need of increased retinal ganglion cell survival and administering a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix (MBVs) to the subject.

Abstract: The present disclosure provides a conductive member for a circuit breaker high voltage portion conductor assembly, the conductive member including a body with a transfer portion and a coupling portion. The body transfer portion has an electro-thermally efficient contour. That is, the body transfer portion has an electrically efficient contour and a thermally efficient contour. The body transfer portion includes a number of slots defining fins. In this configuration, the body transfer portion distributes current generally evenly across a cross-sectional area of the conductive member body. Further, the fins provide heat dissipation via convection.

Abstract: A processing arrangement comprising: a process chamber comprising an upper chamber wall, a lower chamber wall and two lateral chamber walls; an insulating structure, arranged between the processing region and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for thermally insulating the processing region, wherein the insulating structure is configured as gas-permeable at least in sections in such a way that a process gas from the processing region can flow out of the processing region in the direction in each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, through the insulating structure; and a gas channel, arranged between the insulating structure and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for pumping away the process gas which flows through the insulating structure.

Abstract: A method of packaging snack food chips, the method comprising the steps of: (a) providing a plurality of snack food chips as a shingled assembly of the snack food chips; (b) enclosing the shingled assembly within an elongate packaging container; (c) vibrating the shingled assembly supported so as to cause the snack food chips sequentially to fall from a free output end into the elongate packaging container while progressively translationally separating a closed end and the free output end to form a shingled stack extending away from the closed end; and (d) during at least a part of step (c), rotating the elongate packaging container so that the closed end is lowered while decreasing an angle of inclination such that the shingled stack is being progressively formed.

Abstract: Monoclonal antibody that specifically binds the interleukin 1 receptor type 1 (IL-1RAcP), or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616.

Abstract: Monoclonal antibody that specifically binds IL-1RAcP, or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616 The monoclonal antibody is characterized in that it inhibits IL-1RAcP induced NF?B activity, useful in treatment of IL-

Abstract: An apparatus for handling three-dimensionally curved snack food chips. The apparatus includes a first conveyor for conveying a series of the snack food chips on a conveying surface and an inverting station located at an output end of the first conveyor. The inverting station includes an inverter configured for transferring the snack food chips from an output end of the first conveyor into contact with an internal concave surface of the inverter. A drive system for the inverter is configured to move the internal concave surface downwardly to cause movement of the snack food chips downward from an upper portion to a lower portion of the internal concave surface. A depositing station is located and configured for depositing the snack food chips from the lower portion of the internal concave surface onto a second conveyor configured for receiving snack food chips from the depositing station and conveying them away.

Abstract: A method of packaging snack food chips, the method comprising the steps of: (a) providing a plurality of snack food chips as a shingled assembly of the snack food chips; (b) enclosing the shingled assembly within an elongate packaging container; (c) vibrating the shingled assembly supported so as to cause the snack food chips sequentially to fall from a free output end into the elongate packaging container while progressively translationally separating a closed end and the free output end to form a shingled stack extending away from the closed end; and (d) during at least a part of step (c), rotating the elongate packaging container so that the closed end while decreasing an angle of inclination such that the shingled stack is being progressively formed.

Abstract: A manual opening assembly includes a manual actuator assembly. The manual actuator assembly includes a handle assembly and a number of operating levers. The handle assembly includes a handle member structured to be movably coupled to a circuit breaker housing assembly and to move between an operating position and an opening position. The handle member is operatively coupled to the number of operating levers. The number of operating levers are movably coupled to a circuit breaker housing assembly. The operating levers are structured to move between an operating position, wherein the operating levers do not operatively engage a linkage assembly, and an opening position, wherein the operating levers operatively engage the linkage assembly and move the linkage assembly from a closed, second configuration to an open, first configuration.