Abstract: The system and method utilizes a computer system having processors that receive quantitative data from users and generate data to facilitate prioritization and reduction of barriers that prevent patients from receiving medical therapies from a particular healthcare provider in rank order. The processors provide an initial rank order of potential barriers based on calculated correlation coefficient, and determine a subsequent rank order of potential barriers based on the calculated correlation coefficient and other data indicative of the effect of each barrier on the patients. The system and method provides for a systematic, data-driven, and validated process to improve patient access to healthcare providers.

Abstract: The present disclosure generally relates to managing and sharing contextually-relevant media content. In some embodiments, a device receives an input, and in response, displays a suggested collection of media items for sharing with a recipient, wherein the collection is relevant to a message conversation with the recipient. Subsequent to displaying the suggested collection, the device transmits a message to the recipient as part of the message conversation that provides access to the at least a portion of the suggested collection of media items. In some embodiments, a device receives an indication, from an external device, that a first user has shared a first collection of media items with a second user. Subsequent to receiving the indication that the first user has shared the first collection of media items with the second user, the device outputs a prompt to share, with the first user, one or more suggested media items.

Abstract: A device implementing a system for sharing groups of files within a messaging application includes a processor configured to provide, within the messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant. The processor is further configured to, responsive to receiving a selection of the user interface element: transmit, to a server, a request to store the at least one file in association with a shared storage area, and to transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area.

Abstract: The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease.

Abstract: An apparatus for handling three-dimensionally curved snack food chips. The apparatus includes a first conveyor for conveying a series of the snack food chips on a conveying surface and an inverting station located at an output end of the first conveyor. The inverting station includes an inverter configured for transferring the snack food chips from an output end of the first conveyor into contact with an internal concave surface of the inverter. A drive system for the inverter is configured to move the internal concave surface downwardly to cause movement of the snack food chips downward from an upper portion to a lower portion of the internal concave surface. A depositing station is located and configured for depositing the snack food chips from the lower portion of the internal concave surface onto a second conveyor configured for receiving snack food chips from the depositing station and conveying them away.

Abstract: The present disclosure relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity. The disclosure further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer. The disclosure finally encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer.

Abstract: A manual opening assembly includes a manual actuator assembly. The manual actuator assembly includes a handle assembly and a number of operating levers. The handle assembly includes a handle member structured to be movably coupled to a circuit breaker housing assembly and to move between an operating position and an opening position. The handle member is operatively coupled to the number of operating levers. The number of operating levers are movably coupled to a circuit breaker housing assembly. The operating levers are structured to move between an operating position, wherein the operating levers do not operatively engage a linkage assembly, and an opening position, wherein the operating levers operatively engage the linkage assembly and move the linkage assembly from a closed, second configuration to an open, first configuration.

Abstract: A processing arrangement comprising: a process chamber comprising an upper chamber wall, a lower chamber wall and two lateral chamber walls; an insulating structure, arranged between the processing region and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for thermally insulating the processing region, wherein the insulating structure is configured as gas-permeable at least in sections in such a way that a process gas from the processing region can flow out of the processing region in the direction in each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, through the insulating structure; and a gas channel, arranged between the insulating structure and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for pumping away the process gas which flows through the insulating structure.

Abstract: Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.

Abstract: A light emitting device is provided that is generally configured to have a compact shape and a broad pattern of light emission. An example light emitting apparatus may include: a redirector disposed about an axis, the redirector having a first end and a second end, where the first end is narrower than the second end, the redirector defining a cavity between the first end and the second end; a power source at least partially disposed within the cavity defined by the redirector; and a light source disposed around the first end of the redirector about the axis, where the light source is powered by the power source and is configured to project light substantially parallel to the axis, toward the second end of the redirector. The redirector may include a frustoconical shape.

Abstract: A mining machine such as a mining shovel includes a digging assembly having an upward extending boom and a dipper assembly generally horizontally supported by the boom and configured to crowd toward and retract from a vertical bank at a mine site. To determine if the dipper assembly strikes the bank, an electronic controller can calculate a calculated crowd force based in part on a crowd motor torque associated with a crowd motor, a crowd speed of the dipper assembly, and an inertia parameter. If the calculated crowd force exceeds a predetermined first crowd threshold, the electronic controller can register an impact event. In further aspects, the electronic controller can execute a force modification function to modify the crowding forces and a speed reduction function to reduce the crowd speed.

Abstract: In a substrate treatment process, substrates are moved by a transporting device in a transporting direction through a substrate treatment installation having a number of chambers. The substrates are moved by transporting sections of the transporting device driven independently of one another. The transporting sections are driven such that, if substrates dwell temporarily in the transporting section, they are moved back and forth. Stresses in a substrate brought about by differing inputs of heat as a result of both process-induced and malfunction-induced dwell times of the substrate in a chamber are reduced by compensating within the chamber for a structurally brought about input of heat into the substrate, varying periodically over the length of the chamber, during temporary dwelling of the substrate in the chamber by moving the substrate back and forth over at least one period of the heat input by a change of the transporting direction.

Abstract: The present disclosure provides a conductive member for a circuit breaker high voltage portion conductor assembly, the conductive member including a body with a transfer portion and a coupling portion. The body transfer portion has an electro-thermally efficient contour. That is, the body transfer portion has an electrically efficient contour and a thermally efficient contour. The body transfer portion includes a number of slots defining fins. In this configuration, the body transfer portion distributes current generally evenly across a cross-sectional area of the conductive member body. Further, the fins provide heat dissipation via convection.