Abstract: This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a ?-D-ribofuranosyl group and the chromogenic portion forms a detectable indicator following enzyme cleavage. In one aspect of this invention the chromogenic ?-D-ribofuranoside substrate forms a colored substantially non-diffusable indicator. A second aspect of this invention provides novel chromogenic ?-D-ribofuranosides.

Abstract: This invention provides novel chromogenic enzyme substrates which are indoxyl ?-D-ribofuranosides. A process for their production is provided. Methods for detecting ?-D-ribofuranosidase activity are given. The advantages of these novel compounds includes: detecting ?-D-ribofuranosidase activity with high sensitivity and low substrate concentrations and use with other enzyme indicators in situations where a plurality of enzyme activities is to be visualized simultaneously e.g. for identifying bacteria growth on solid growth media. The synthesis and use of 5-bromo-4-chloro-3-indolyl-?-D-ribofuranoside is exemplified.

Abstract: Described is a soluble stable liquid formulation, process for preparing, and a method of using the soluble stable liquid formulation comprising ractopamine or a physiologically acceptable salt thereof, a liquid nonionic cosolvent, and water.

Abstract: A semi-rotary unit for continuously cutting or printing articles from sheets or from a continuous web, includes a rotary cylinder for supporting about its circumference a removable plate and defining a cutting or printing station, a conveyor for sequentially conveying sheets or a continuous web past the rotary cylinder, and a motor for driving the rotary cylinder and the conveyor. The unit further includes means for determining a correction factor for plates which are originally manufactured for use on a rotary cylinder having a different diameter to that of the unit, and control means for varying the speed of the rotary cylinder relative to the sheets or continuous web in accordance with the correction factor.

Abstract: A press includes an upper platen and a heated lower platen that are selectably movable toward and away from each other. A vessel inserted between an upper platen and a heated lower platen is conformally but nondeformingly secured therebetween so that vessel surfaces in conformal contact with the upper platen and the lower platen remain substantially undeformed while the vessel is filled with a pressurized insulating foam material. A portion of the vessel that is heated to at least a predetermined temperature by the heated lower platen promotes uniform expansion and curing of the injected foam within the vessel, and additionally promotes bonding between the injected foam and the heated portion of the vessel.

Abstract: This invention provides novel chromogenic enzyme substrates which are indoxyl ?-D-ribofuranosides. A process for their production is provided. Methods for detecting ?-D-ribofuranosidase activity are given. The advantages of these novel compounds includes: detecting ?-D-ribofuranosidase activity with high sensitivity and low substrate concentrations and use with other enzyme indicators in situations where a plurality of enzyme activities is to be visualized simultaneously e.g. for identifying bacteria growth on solid growth media. The synthesis and use of 5-bromo-4-chloro-3-indolyl-?-D-ribofuranoside is exemplified.

Abstract: A semi-rotary unit for continuously cutting or printing articles from sheets or from a continuous web, includes a rotary cylinder for supporting about its circumference a removable plate and defining a cutting or printing station, a conveyor for sequentially conveying sheets or a continuous web past the rotary cylinder, and a motor for driving the rotary cylinder and the conveyor. The unit further includes means for determining a correction factor for plates which are originally manufactured for use on a rotary cylinder having a different diameter to that of the unit, and control means for varying the speed of the rotary cylinder relative to the sheets or continuous web in accordance with the correction factor.

Abstract: This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a &bgr;-D-ribofuranosyl group and the chromogenic portion forms a detectable indicator following enzyme cleavage. In one aspect of this invention the chromogenic &bgr;-D-ribofuranoside substrate forms a coloured substantially non-diffusable indicator. A second aspect of this invention provides novel chromogenic &bgr;-D-ribofuranosides.

Abstract: This invention provides a method of detecting enzyme activity on a solid medium. The enzyme substrate has a chromogenic portion comprising a catechol residue, in which a derivitising moiety is linked to the aromatic ring of the catechol via a bond, and an enzyme cleavable group which is attached via an ester or ether linkage to the oxygen atom derived from a hydroxyl group of the catechol residue. If the enzyme substrate contacts an enzyme capable of cleaving the enzyme cleavable groups and the cleaved compound contacts a chelatable metal ion, a substantially non-diffusable coloured precipitate is formed.

Abstract: An apparatus for continuously winding a web of sheet material into rolls comprises a turret mechanism (1) comprising two or more winding mandrels (2,3,4,5). The turret mechanism (1) is rotatably indexed to bring each mandrel (2,3,4,5) in turn into a winding position in which it is rotatably driven to wind a web of sheet material (8) connected thereto into a roll, and to bring the adjacent mandrel lying immediately behind it in the direction of rotation of the turret into contact with the web (8). The adjacent mandrel is rotatable. Rotary element (11) is adapted for selective engagement with the adjacent mandrel, which rotary element (11) is rotatably driven in the opposite direction to the adjacent mandrel and at a greater speed. The apparatus further comprises a web cutting mechanism (16) adapted to cut the web (8) at a point lying between the current rewind mandrel and the adjacent mandrel.

Abstract: A toy capable of emitting clapping noise, emitting scent, and emitting light. The toy is constructed with an elongated central member and a plurality of resilient ribs which are attached at one of their ends to the elongated central member and are attached at their other end to a sliding collar. The sliding collar is free to slide along the elongated member thereby causing the resilient ribs to move radially outwardly with respect to the longitudinal axis of the elongated central member.