Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.

Abstract: A head-mounted device is provided that includes one or more cameras configured to acquire a raw video feed and one or more displays configured to present a passthrough video feed to a user. Generation of the passthrough video feed can involve processing the raw video feed using an image signal processor and auxiliary compute blocks. One or more of the auxiliary compute blocks can be bypassed in response to detecting one or more failures associated with the auxiliary compute blocks. Configured and operated in this way, the head-mounted device can fall back to a more reliable passthrough video feed without having to power cycle the head-mounted device when a failure occurs.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: An electric vehicle supply equipment (EVSE) charging station for charging a propulsion battery pack of an electric vehicle (EV) includes a charging cabinet, an electrical cable, a charge coupler, and a cradle operable for stowing the charge coupler. The charging station provides a charging voltage or current to the battery pack during a charging operation of the EV. The electrical cable has a distal end connected to the charging cabinet. The charge coupler is connected to a proximal end of the electrical cable and connects to a charge receptacle of the EV. The cradle includes at least one heating element connected thereto. The heating element is configured to selectively heat the cradle body in response to the environmental state of the cradle body being indicative of accumulated snow or ice on the charge coupler and/or the cradle body.

Abstract: An electric vehicle supply equipment (EVSE) charging station for charging a propulsion battery pack of an electric vehicle (EV) includes a charging cabinet, an electrical cable, and a charge coupler. The charging station is operable for providing a charging voltage or current to the battery pack during a charging operation. The electrical cable has a distal end connected to the charging cabinet. The charge coupler is connected to a proximal end of the electrical cable and connects to a charge receptacle of the EV. The charge coupler includes at least one heating element connected to the charge coupler. The heating element is configured to selectively heat the charge coupler in response to the environmental state being indicative of accumulated snow or ice on the charge coupler.

Abstract: An apparatus for mounting a liftgate column on a vehicle comprises a plurality of buttons attached to an outer housing of the liftgate column, wherein the plurality of buttons are arranged to project outwardly from a mounting wall of the housing and mate with the plurality of keyholes of the vehicle. Where the vehicle is without corresponding keyholes, a mounting member having corresponding keyholes is disclosed for welding to the vehicle.

Abstract: A testing system and test cartridge for analyzing a sample of water from a water source for specific analyte levels. The test cartridge including a membrane filter that captures a target analyte while allowing a labelled conjugate to permeate through the membrane. The conjugate includes an analyte-specific labelled binding reagent to bind with the target analyte for optical detection. The direct membrane interrogation (i.e., on-filter detection), determines analyte levels without elution of the analyte from a filter thereby improving analyte recovering and assay sensitivity.

Abstract: A sideloader liftgate system automatically extends a stabilizer leg when a liftgate is deployed, and automatically retracts the stabilizer leg when the liftgate is stored. Adjustment of the liftgate and stabilizer leg is carried out in response to a single user command. The invention prevents a user from forgetting to extend the stabilizer leg for safely using the liftgate, and also prevents a user from forgetting to retract the stabilizer leg before towing the trailer.

Abstract: A sideloader liftgate system automatically extends a stabilizer leg when a liftgate is deployed, and automatically retracts the stabilizer leg when the liftgate is stored. Adjustment of the liftgate and stabilizer leg is carried out in response to a single user command. The invention prevents a user from forgetting to extend the stabilizer leg for safely using the liftgate, and also prevents a user from forgetting to retract the stabilizer leg before towing the trailer.

Abstract: Customized patient-specific orthopedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: An assembly tool for assembly of a first component of a prosthesis to a second component of the prosthesis for use in joint arthroplasty is provided. The tool includes a first member in contact with the first component and a second member connected to the second component. The first member defines a first member longitudinal axis. The first member and the second member provide for the assembly of the first component of the prosthesis to the second component of the prosthesis. The second member provides relative motion of the second member with respect to the first member when the second member is rotated relative to the first member about the first member longitudinal axis. The first member and the second member have relative motion features adapted to reduce friction that cooperate with each other to provide the relative motion of the first member with respect to the second member.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: Apparatus and methods for cutting a material, especially with low material speed and high cutting torque. In some embodiments, the apparatus is a hand-held device for quietly cutting through an orthopedic cast with little or no generation of debris. In yet other embodiments, there is a method for automatically advancing material past a shearing surface, such that the shearing action occurs at about the same velocity as the advancement. In yet other embodiments, there is a device for cutting material between a foot and a sharp edge, with the bottom of the foot being under the sharp edge to protect the skin of the patient.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.

Abstract: An assembly tool for assembly of a first component of a prosthesis to a second component of the prosthesis for use in joint arthroplasty is provided. The tool includes a first member in contact with the first component and a second member connected to the second component. The first member defines a first member longitudinal axis. The first member and the second member provide for the assembly of the first component of the prosthesis to the second component of the prosthesis. The second member provides relative motion of the second member with respect to the first member when the second member is rotated relative to the first member about the first member longitudinal axis. The first member and the second member have relative motion features adapted to reduce friction that cooperate with each other to provide the relative motion of the first member with respect to the second member.

Abstract: An assembly tool for assembly of a first component of a prosthesis to a second component of the prosthesis for use in joint arthroplasty is provided. The tool includes a first member in contact with the first component and a second member connected to the second component. The first member defines a first member longitudinal axis. The first member and the second member provide for the assembly of the first component of the prosthesis to the second component of the prosthesis. The second member provides relative motion of the second member with respect to the first member when the second member is rotated relative to the first member about the first member longitudinal axis. The first member and the second member have relative motion features adapted to reduce friction that cooperate with each other to provide the relative motion of the first member with respect to the second member.

Abstract: Customized patient-specific orthopaedic surgical instruments are disclosed. Methods for fabricating and using such instruments are also disclosed.