Patents by Inventor Michael D. Bentley

Michael D. Bentley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10463958
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 5, 2019
    Assignee: K-Motion Interactive, Inc.
    Inventor: Michael D. Bentley
  • Patent number: 10463659
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: November 5, 2019
    Assignee: Nektar Therapeutics
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
  • Patent number: 10456676
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 29, 2019
    Assignee: K-Motion Interactive, Inc.
    Inventor: Michael D. Bentley
  • Publication number: 20190054376
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Application
    Filed: October 19, 2018
    Publication date: February 21, 2019
    Inventor: Michael D. BENTLEY
  • Publication number: 20190046651
    Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
    Type: Application
    Filed: October 15, 2018
    Publication date: February 14, 2019
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Publication number: 20190022236
    Abstract: Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 24, 2019
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20190015745
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 17, 2019
    Inventor: Michael D. BENTLEY
  • Publication number: 20190000985
    Abstract: In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.
    Type: Application
    Filed: September 10, 2018
    Publication date: January 3, 2019
    Inventors: Randall W. MOREADITH, Michael D. BENTLEY, Zhihao FANG, Tacey VIEGAS
  • Patent number: 10130720
    Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: November 20, 2018
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Publication number: 20180256599
    Abstract: The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.
    Type: Application
    Filed: October 19, 2017
    Publication date: September 13, 2018
    Inventors: Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
  • Patent number: 10071168
    Abstract: In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: September 11, 2018
    Assignee: Serina Therapeutics, Inc.
    Inventors: Randall W Moreadith, Michael D Bentley, Zhihao Fang, Tacey Viegas
  • Publication number: 20180250367
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Application
    Filed: May 17, 2018
    Publication date: September 6, 2018
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • Patent number: 10035880
    Abstract: Provided are methods of preparing heterobifunctional poly(ethylene glycol) derivatives (e.g., HO-PEG-OCH2CO2H) by alkylating poly(ethylene glycol). A method comprises: (a) synthesizing Ar—CR1R2O-Poly-OH (e.g., Bz-PEG-OH, where Bz is benzyl) by forming a polymer Poly (e.g., HO-PEG-OH) onto the aryl methyl oxide ion, Ar—CR1R2O?; (b) alkylating Ar—CR1R2O-Poly-OH to form Ar—CR1R2—O-poly-OR9 (e.g., Bz-O-PEG-OCH2CO2(CH3)3); (c) converting the Ar—CR1R2O— moiety to —OH by acid-catalyzed hydrolysis or hydrogenolysis to form a new mixture of R9O-PEG-OH and R9O-PEG-OR9 (e.g., HO-PEG-OCH2CO2H and HO2CCH2O-PEG-OCH2CO2H); and (d) optionally, isolating the R9O-PEG-OH product formed in (c). The method of the present invention obviates the extensive and laborious purification prior art steps normally required to remove HO-Poly-OH (e.g., HO-PEG-OH) from a preparation of the PEG derivatives.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: July 31, 2018
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • Patent number: 9999657
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 19, 2018
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • Patent number: 9913913
    Abstract: A method for preparing a polymeric reagent is provided, which method includes the optional step of forming an N-hydroxysuccinimdyl ester derivative. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 13, 2018
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20180056184
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Application
    Filed: September 14, 2017
    Publication date: March 1, 2018
    Inventor: Michael D. BENTLEY
  • Publication number: 20180021444
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Application
    Filed: October 3, 2017
    Publication date: January 25, 2018
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
  • Publication number: 20170348426
    Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
    Type: Application
    Filed: August 18, 2017
    Publication date: December 7, 2017
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Patent number: 9775911
    Abstract: The present invention provides among other things a composition of a polymeric reagent and an antioxidant, such as butylated hydroxyl toluene.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: October 3, 2017
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Patent number: 9770658
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: September 26, 2017
    Assignee: K-MOTION Interactive, Inc.
    Inventor: Michael D Bentley