Patents by Inventor Michael D. Bentley

Michael D. Bentley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Branched polymers
    Patent number: 9187569
    Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: November 17, 2015
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Xuan Zhao, Xiaoming Shen, William D. Battle, III
  • Methods for preparing polymeric reagents
    Patent number: 9090740
    Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: July 28, 2015
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • CHEMICALLY MODIFIED SMALL MOLECULES
    Publication number: 20150197470
    Abstract: Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.
    Type: Application
    Filed: April 8, 2014
    Publication date: July 16, 2015
    Applicant: Nektar Therapeutics
    Inventors: Michael D. BENTLEY, Tacey X. Viegas, Richard R. Goodin, Lin Cheng, Xuan Zhao
  • Oligomer-Antihistamine Conjugates
    Publication number: 20150174264
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
    Type: Application
    Filed: March 6, 2015
    Publication date: June 25, 2015
    Applicant: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Wen Zhang, Tacey X. Viegas, Michael D. Bentley
  • Pharmaceutical compositions of conjugates formed from polymer derivatives having particular atom arrangements
    Patent number: 9044516
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 2, 2015
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Hydrolytically degradable alkylene oxide based polymers
    Patent number: 9040060
    Abstract: The present invention provides a water soluble, non-peptidic polymer comprising two or more alkylene oxide-based oligomers linked together by hydrolytically degradable linkages such as carbonates. Typically, the oligomer portion of the polymer is an amphiphilic triblock copolymer having a central propylene oxide block or butylene oxide block positioned between two ethylene oxide blocks. The polymer can be hydrolytically degraded into oligomers under physiological conditions. In aqueous media, the polymer preferably forms thermally reversible, hydrolytically degradable hydrogels that can be used, for example, for drug delivery and related biomedical applications.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: May 26, 2015
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Xuan Zhao, William Dudley Battle, III, Xiaoming Shen
  • METHODS FOR PREPARING POLYMERIC REAGENTS
    Publication number: 20150141665
    Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
    Type: Application
    Filed: December 15, 2014
    Publication date: May 21, 2015
    Applicant: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Heterobifunctional Poly(ethylene glycol) Derivatives and Methods for Their Preparation
    Publication number: 20150107489
    Abstract: This invention provides a method related to the preparation of derivatives of poly(ethylene glycol).
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Applicant: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • Polyoxazolines with Inert Terminating Groups, Polyoxazolines Prepared from Protected Initiating Groups and Related Compounds
    Publication number: 20150080538
    Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.
    Type: Application
    Filed: November 10, 2014
    Publication date: March 19, 2015
    Inventors: Michael D. BENTLEY, J. Milton HARRIS, Kunsang YOON, Michael REIF, Rainer JORDAN
  • UNIT DOSAGE FORMS OF PHARMACEUTICAL COMPOSITIONS COMPRISING A POLYMER-FACTOR VIII POLYPEPTIDE CONJUGATE
    Publication number: 20150038422
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
    Patent number: 8940801
    Abstract: This invention provides a method related to the preparation of derivatives of poly(ethylene glycol), wherein the method comprises increasing the pH of an aqueous composition comprising a poly(ethylene glycol) bearing a —O—(CH2)n—CO2R3 functional group to result in an aqueous composition comprising a poly(ethylene glycol) bearing a —O—(CH2)n—CO2H functional group, wherein R3 is alkyl and (n) in each instance is 1-6.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: January 27, 2015
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • OLIGOMER-NITROIMIDAZOLE ANTI-INFECTIVE CONJUGATES
    Publication number: 20140378520
    Abstract: The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
    Type: Application
    Filed: September 4, 2014
    Publication date: December 25, 2014
    Inventors: Zhongxu Ren, Jennifer Riggs-Sauthier, Michael D. Bentley
  • Water-Soluble Polymer Conjugates of Topotecan
    Publication number: 20140371258
    Abstract: Provided herein are water-soluble polymer conjugates of topotecan, along with compositions comprising the conjugates and related methods of making and using the same.
    Type: Application
    Filed: December 16, 2011
    Publication date: December 18, 2014
    Applicant: Nektar Therapeutics
    Inventors: Xuyuan Gu, Jennifer Riggs-Sauthier, Michael D. Bentley, Tacey X. Viegas
  • Methods for preparing polymeric reagents
    Patent number: 8911718
    Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: December 16, 2014
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Unit dosage forms of pharmaceutical compositions comprising a polymer-factor VIII polypeptide conjugate
    Patent number: 8889831
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 18, 2014
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • BRANCHED POLYMERS
    Publication number: 20140329994
    Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 6, 2014
    Inventors: Michael D. Bentley, Xuan Zhao, Xiaoming Shen, William D. Battle, III
  • OLIGOMER-CORTICOSTEROID CONJUGATES
    Publication number: 20140309398
    Abstract: The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits different properties compared to the properties of the corticosteroid not attached to the water-soluble oligomer.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 16, 2014
    Inventors: Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
  • CHEMICALLY MODIFIED SMALL MOLECULES
    Publication number: 20140303403
    Abstract: Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 9, 2014
    Applicant: Nektar Therapeutics
    Inventors: Michael D. BENTLEY, Tacey X. Viegas, Richard R. Goodin, Lin Cheng, Xuan Zhao
  • Oligomer-nitroimidazole anti-infective conjugates
    Patent number: 8853247
    Abstract: The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 7, 2014
    Assignee: Nektar Therapeutics
    Inventors: Zhongxu Ren, Jennifer Riggs-Sauthier, Michael D. Bentley
  • Pharmaceutical Compositions of Conjugates Formed From Polymer Derivatives Having Particular Atom Arrangements
    Publication number: 20140227218
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Application
    Filed: December 20, 2013
    Publication date: August 14, 2014
    Applicant: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles