Patents by Inventor Michael D. Bentley

Michael D. Bentley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligomer-corticosteroid conjugates
    Patent number: 8796248
    Abstract: The invention provides corticosteroids that are chemically modified by covalent attachment of a water soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water soluble oligomer.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: August 5, 2014
    Assignee: Nektar Therapeutics
    Inventors: Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
  • METHOD AND SYSTEM FOR ATHLETIC MOTION ANALYSIS AND INSTRUCTION
    Publication number: 20140114453
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Application
    Filed: December 30, 2013
    Publication date: April 24, 2014
    Applicant: K-Motion Interactive, Inc.
    Inventor: Michael D. Bentley
  • Methods for preparing conjugates
    Patent number: 8703115
    Abstract: The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: April 22, 2014
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Methods for Preparing Polymeric Reagents
    Publication number: 20140107349
    Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
    Type: Application
    Filed: December 17, 2013
    Publication date: April 17, 2014
    Applicant: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Methods for forming polymer-drug conjugates
    Patent number: 8633277
    Abstract: Methods for preparing polymer-drug conjugates are provided. The disclosed methods involve polymeric reagents comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. Related methods, compositions, preparations, and so forth are also provided.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: January 21, 2014
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Method and system for athletic motion analysis and instruction
    Patent number: 8616989
    Abstract: A system and method for analyzing and improving the performance of a body motion of an animal or human subject requires instrumenting a subject with inertial sensors, monitoring a body motion of interest, converting sensor data into motion data and animation, comparing the motion data with existing data for motion related performance parameters, providing a real-time, information rich, animation and data display of the results in color coded displays; and based on the results prescribing a training regime with exercises selected from a library of standardized exercises using standardized tools and training aids.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: December 31, 2013
    Assignee: K-Motion Interactive, Inc.
    Inventor: Michael D Bentley
  • Polymer-factor VIII conjugate compositions
    Patent number: 8618259
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: December 31, 2013
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • Stereoselective reduction of a morphinone
    Patent number: 8563726
    Abstract: A synthetic method is provided, wherein the method comprises stereoselectively reducing a ketone of a morphinone to form a reduced morphinone and optionally covalently attaching a water soluble polymer to the reduced morphinone.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 22, 2013
    Assignee: Nektar Therapeutics
    Inventors: Lin Cheng, Michael D. Bentley
  • Polymer Factor VIII moiety conjugates
    Patent number: 8519102
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: August 27, 2013
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
    Patent number: 8450390
    Abstract: The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: May 28, 2013
    Assignee: Nektar Therapeutics
    Inventors: Zhihao Fang, Michael D. Bentley
  • Pharmaceutical compositions and methods for delivering such compositions
    Patent number: 8435505
    Abstract: The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: May 7, 2013
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • OLIGOMER-ANTIHISTAMINE CONJUGATES
    Publication number: 20130053400
    Abstract: The invention provides antihistamine drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the antihistamine drug not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 7, 2012
    Publication date: February 28, 2013
    Applicant: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Wen Zhang, Tacey X. Viegas, Michael D. Bentley
  • Segmented polymers and their conjugates
    Patent number: 8383380
    Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: February 26, 2013
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Xiaoming Shen, Michael D. Bentley, Zhihao Fang, Tony L. Sander
  • STEREOSELECTIVE REDUCTION OF A MORPHINONE
    Publication number: 20130018190
    Abstract: A synthetic method is provided, wherein the method comprises stereoselectively reducing a ketone of a morphinone to form a reduced morphinone and optionally covalently attaching a water soluble polymer to the reduced morphinone.
    Type: Application
    Filed: April 13, 2012
    Publication date: January 17, 2013
    Applicant: Nektar Therapeutics
    Inventors: Lin Cheng, Michael D. Bentley
  • Multi-arm polymer prodrugs
    Patent number: 8318145
    Abstract: Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: November 27, 2012
    Assignee: Nektar Therapeutics
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
  • METHODS FOR THE FORMATION OF HYDROGELS USING THIOSULFONATE COMPOSITIONS AND USES THEREOF
    Publication number: 20120289609
    Abstract: The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 15, 2012
    Applicant: Nektar Therapeutics
    Inventors: Zhihao FANG, Michael D. BENTLEY
  • PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DELIVERING SUCH COMPOSITIONS
    Publication number: 20120258912
    Abstract: The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 11, 2012
    Applicant: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • POLYMER FACTOR VIII MOIETY CONJUGATES
    Publication number: 20120244597
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Application
    Filed: March 27, 2012
    Publication date: September 27, 2012
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • POLYMER-FACTOR VIII MOIETY CONJUGATES
    Publication number: 20120245289
    Abstract: Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
    Type: Application
    Filed: March 27, 2012
    Publication date: September 27, 2012
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Mary J. Bossard, Michael D. Bentley, Ping Zhang
  • Multi-arm polymer prodrugs
    Patent number: 8263062
    Abstract: Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: September 11, 2012
    Assignee: Nektar Therapeutics
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas