Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genito-urinary, gastrointestinal, and respiratory disorders: wherein R1 is —C(?S)CH3, pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, furyl, furylcarbonyl, acetyl, or carbamoyl; R2a and R2b are independently H, methyl, or ethyl; R3 is H or methyl; Y is a bond, —(CR4R5)n— or —CR4?CR5—; wherein R4 and R5 are each independently H or methyl and n is 1 or 2; X is N or CH; A is phenyl, 5-membered heterocyclyl, or 6-membered heterocyclyl; R6, R7 and R8 are each independently H, halo, lower alkyl, cycloalkyl, alkylthio, alkylthio-lower alkyl, alkylsulfonyl-lower alkyl, di(lower alkyl)amino-lower alkyl, morpholinyl-lower alkyl, 4-methyl-piperazinyl-methyl, trifluoromethyl, pyridyl, tetrazolyl, thiophenyl, phenyl, biphenyl, or benzyl (where thiophenyl, phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoromethyl, lower alkoxy or lower alkylthio) or R6 and R7 together form a 5-membered or 6-membered carboc

Abstract: Base platforms customizable into ICs are designed by identifying a plurality of macros for placement on the platform, each macro being defined in part by a plurality of elements that perform respective functions of the macro. Identical elements in a plurality of macros are identified, and a common element is placed on the platform for an identical element of at least two macros. All other elements of the macros are placed at locations on the platform relative to the common element as to satisfy macro placement rules for each macro. Identical elements can be identified by identifying similar elements in a plurality of macros, and creating a common element generic to the similar elements. The user designs a metalization layer to select macros and configure common elements to the selected macros.

Abstract: A method and apparatus are provided for placing cells in an integrated circuit layout pattern. A base layer layout pattern defines an array of base cell locations and base layer elements, wherein at least portions of some rows in the array are reserved for decoupling capacitor cells. Each decoupling capacitor cell has a width, which is greater than that of a single base cell location and which is abstracted from the base layer layout pattern. A cell library defines a plurality of cells, including a macro cell having open rows consistent with the rows in the base layer layout pattern that are reserved for the decoupling capacitor cells. The width of each decoupling capacitor cell is abstracted from the macro cell. Cells from the cell library, including the macro cell, are placed within a design layout pattern relative to the base layer layout pattern. An area consumed by the macro cell within the design layout pattern is independent of the width of the decoupling capacitor cells.

Abstract: A subscriber access control system (SACS) configures a network device connected to cable network to affect the behavior of that device. The SACS comprises a rules engine and a datastore that stores the current state of subscribers known to the SACS and historical request information. When the SACS receives a request to quarantine a device, it assigns attributes to a subscriber record accessed by a DHCP server to affect the configuration and behavior of that device. The actual behavior of the quarantined device is determined by the presence of the attribute and the value of the attribute.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: A system and method for mapping IP components onto a pre-fabricated chip slice allows a user to select a target location for placement of an IP component onto a slice. A slice definition of the pre-fabricated chip slice is searched for a legal location for the IP component that is near to the target location. The IP component is mapped to the legal location.

Abstract: A top cover and safing sector assembly of a 7.

Abstract: A command processor of an integrated circuit design suite has a graphical user interface and a command interpreter for interpreting user commands. The graphical user interface is specified entirely by a user at run time. One or more design tools corresponding to processes within an integrated circuit design process operate under the control of the command processor and within the graphical user interface.

Abstract: An integrated circuit is provided, which includes first, second and third power supply conductors. The second power supply conductor has a higher voltage than the first power supply conductor, and the third power supply conductor has a higher voltage than the second power supply conductor. A high voltage power supply decoupling capacitor is coupled between the first and third power supply conductors. A low voltage power supply decoupling capacitor coupled between the first and second power supply conductors. A voltage reducer is coupled between the second and third power supply conductors. A plurality of semiconductor devices is biased between the first and second power supply conductors.

Abstract: A railroad car energy absorption apparatus is disclosed. The railroad car energy absorption apparatus includes a spring assembly having an elastomer spring element arranged in operable combination with structure for inhibiting localized heat deterioration of the elastomer spring element.

Abstract: A pre-diffused high density array of core memory cells is provided in a metal programmable device. The peripheral logic is made up of gate array cells in the metal programmable device. The peripheral logic may be configured to access the core memory cells as various memory types, widths, depths, and other configurations. If the entire memory is not needed, then the unused memory cells can be used as logic gates. The application-specific circuit, including peripheral logic, memory interface logic, and memory configuration is programmed with a metal layer.

Abstract: A pre-diffused high density array of core memory cells is provided in a metal programmable device. The peripheral logic is made up of gate array cells in the metal programmable device. The peripheral logic may be configured to access the core memory cells as various memory types, widths, depths, and other configurations. If the entire memory is not needed, then the unused memory cells can be used as logic gates. The application-specific circuit, including peripheral logic, memory interface logic, and memory configuration is programmed with a metal layer.

Abstract: The present invention concerns a method (200) and a system (100) for automatically refreshing previously recorded data on a recordable storage medium during playback of the previously recorded data from the recordable storage medium. The method includes the steps of: reading (212) a segment of the previously recorded data from the recordable storage medium; and re-writing (218) at least a portion of the segment of the previously recorded data back onto the recordable storage medium. In addition, the method can include the step of selectively examining (214) the segment of the previously recorded data by searching for errors in the previously recorded data in which the re-writing step can be performed only if the level of errors in the previously recorded data reaches a predetermined level.

Abstract: A self-service terminal (10) having a user interface (14) for interacting with a user (12) is described. The terminal (10) may be an ATM and includes a programmable personality controller (74), and control means (72) such as an ATM application program. The personality controller (72) has a plurality of different personality settings. The control means (72) is responsive to the programmable personality controller (74) and adapts the ATM's interaction with the user in response to the setting of the personality controller (74). A method of interacting with a user at a self-service terminal is also described.

Abstract: A method for controlling a system for processing stored information on a storage medium, includes the following steps. Information on the storage medium is played back using one of a plurality of repeat modes during a play mode of operation. During the play mode of operation, a user is provided with an opportunity to select a repeat mode from among the plurality of repeat modes. The playback of the information on the storage medium is then changed to the selected repeat mode during the play mode of operation. Apparatus for processing information includes playback circuitry for retrieving information from the storage medium during a play mode of operation. A user control device is coupled to playback circuitry and receives user input.

Abstract: A pneumatic carrier system is provided for distribution and transport of materials between different locations. The system includes a plurality of carriers for conveyance of materials and a control system for controlling the movement of the carriers in the system. The control system uses information associated with the carriers and the status of areas of the system to detect gridlock conditions which inhibit the movement of carriers. The system also includes bypass locations which are used to resolve detected gridlock conditions.

Abstract: Apparatus for blindfolding a bird, comprising an elongated handle, a deformable split ring attached to the handle, where the ring includes at least one peripheral flange, and a pliant hood, having an opening in one end thereof, detachably mounted around the circumference of the split ring and where the perimeter of the hood's opening is elastic and is adapted to fit under the peripheral flange.