Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.

Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: A method for joining a valve member for use within a valve, the method including brazing a body portion having a head and a base, the base having a bore extending a depth therein, to a leg portion having a shaft, the shaft having a distal end, a proximal end opposite the distal end, and a plurality of legs extending radially and axially therefrom and away from the proximal end, the brazing including placing a braze material between the bore and the proximal end, inserting the proximal end into the bore such that a portion of an outer surface of the proximal end is adjacent to an inner surface of the bore, and heating at least the adjacent surfaces to a braze temperature.

Abstract: A method is disclosed for the retrieval and recovery of organic-based or organic-containing materials, including naturally occurring substances such as crude oil, and other petroleum-based or containing materials, natural gas, and the like, from environments where they are entrained within or otherwise admixed or complexed with other organic or inorganic materials, such as rock, sand, shale and the like. The method comprises: retrieving a quantity of the petroleum-containing mixture, treating the petroleum-containing mixture with a solvent for the petroleum material to separate the petroleum material from the mixture, and recovering the separated petroleum-containing material. The solvent may be at approximately ambient temperature and may be, for instance, heptane, hexane, naphtha, kerosene, gasoline or a petroleum based solvent or any other suitable solvent in which the asphalt binder is soluble.

Abstract: The liquid pump includes an inner and an outer tube. The inner tube can have a distal end that is positioned within an interior volume of the outer tube. A conical filter is on the distal end of the inner tube. A gas pump provides compressed air which is output through a plurality of inner tube holes on an inner surface of the inner tube on a distal portion of the inner tube and a plurality of annular space holes which are adjacent to an annular space between the inner tube and the outer tube.

Abstract: A modular, easily constructible exercise assembly providing pull-up type exercise routines is disclosed. This particular solution is designed to be secured to a stationary upright object, or anchor. The unique construction of the exercise assembly can be broken down into base components to conveniently fit into a back pack. Its specific structure and design is optimized to limit wear and material failure. Additionally, adjustability is provided to various components as detailed herein. For example, an exercise bar can articulate at different angles and extend and lengthen as selected by a user. Also, a securing bar is adjustable for coupling the exercise assembly to different sized stationary objects.

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: The invention provides freeze-dried nucleated cells, a method for preparing them, and methods of using them for in vitro assays and in vivo therapeutic treatments. The method for preparing the cells includes incubating cells in the presence of a cryoprotective sugar to load them with the sugar, then lyophilizing them without separating the cells from the cryoprotective sugar. In embodiments, the cells are also loaded with one or more bioactive agents.

Abstract: The liquid pump includes an inner and an outer tube. The inner tube can have a distal end that is position within interior volume of the outer tube. A conical filter is on the distal end of the inner tube. A gas pump provides compressed air which is output through a plurality of inner tube holes on an inner surface of the inner tube on a distal portion of the inner tube and a plurality of annular space holes which are adjacent to an annular space between the inner tube and the outer tube.

Abstract: A method is disclosed for the retrieval and recovery of organic-based or organic-containing materials, including naturally occurring substances such as crude oil, and other petroleum-based or containing materials, natural gas, and the like, from environments where they are entrained within or otherwise admixed or complexed with other organic or inorganic materials, such as rock, sand, shale and the like. The method comprises: (a) retrieving a quantity of the petroleum-containing mixture, (b) treating the petroleum-containing mixture with a solvent for the petroleum material to separate the petroleum material from the mixture and (c) recovering the petroleum-containing material separated in step (b). The method also includes the reclamation or recycling of asphalt or asphalt components to produce reusable asphalt or asphalt components featuring (a) providing crushed asphalt or asphalt components, and (b) adding the asphalt or asphalt components to a solvent in which the asphalt binder is soluble.

Abstract: A method to reclaim or recycle asphalt or asphalt components to produce reusable asphalt or asphalt components featuring (a) providing crushed asphalt or asphalt components, and (b) adding the asphalt or asphalt components to a solvent in which the asphalt binder is soluble. The solvent may be at approximately ambient temperature and may be, for instance, heptane, hexane, naphta, kerosene, gasoline or a petroleum based solvent or any other suitable solvent in which the asphalt binder is soluble. The solvent may be added in a standard automated parts washer or equivalent equipment to provide exposure to one or more solvents in which the asphalt binder is soluble.

Abstract: The present invention is directed to a composition containing at least one salt, at least one natural or synthetic saccharide, and at least one natural or synthetic high molecular weight, non-ionic, hydrophilic polymer. When in a liquid form, the composition is ready for infusion or injection to patients that suffer from loss of fluids that causes reduced volume and/or pressure in the systemic circulation. The composition is also suitable for treatment of organ conditions where blood flow is impaired or insufficient, resulting in organ distress, including tissue loss. The invention also relates to use as a prophylaxis to prevent medical consequences of anticipated conditions where depleted circulatory fluids, low blood pressure, or impaired organ perfusion require correction.

Abstract: A modular, easily constructible exercise assembly providing pull-up type exercise routines is disclosed. This particular solution is designed to be secured to a stationary upright object, or anchor. The unique construction of the exercise assembly can be broken down into base components to conveniently fit into a back pack. Its specific structure and design is optimized to limit wear and material failure. Additionally, adjustability is provided to various components as detailed herein. For example, an exercise bar can articulate at different angles and extend and lengthen as selected by a user. Also, a securing bar is adjustable for coupling the exercise assembly to different sized stationary objects.

Abstract: A solid overlay for laser shock peening is described herein. The solid overlay includes a transparent or translucent material, wherein the solid overlay is structured and adapted to a shape of a surface of a component to be treated by the laser shock peening. The solid overlay is configured to confine a plasma plume generated by laser light.

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: Disclosed are methods, apparatus, systems, and computer readable storage media for trials onboarding. A server may receive a request to generate a trial instance of an organization providing data and functionality for a period of time. Data on the request may also be stored. The trial instance may be selected from a template based on an access channel corresponding to the request.