Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: A method and a system for contextual recognition through screen-sharing are provided. Example embodiments may include receiving a data stream related to a presenter screen in a network-based collaboration session from a first user; extracting characteristic data from the data stream; associating added data with the data stream, based on the data; and presenting, in real time, to a second user, a viewer screen including the data stream and the added data. The method may also include recognizing the characteristic data before the extracting of the data.

Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: A novel price paid database, method, system, and computer program product in which checkout items are scanned at a plurality of stores, and a checkout computer identifies the purchased items. The checkout computer determines a price paid for each purchased item. A central computer records in a price-paid database an item identification and price-paid for each purchased items. The central computer publishes the price-paid database. The checkout computer recurrently updates the price-paid database in the central computer with the price paid for each purchased item, the customer identification (if available), the store identification, and a list price for each purchased item.

Abstract: System and method for utilizing motion capture data for healthcare compliance, sporting, gaming, military, virtual reality, industrial, retail loss tracking, security, baby and elderly monitoring and other applications for example obtained from a motion capture element and relayed to a database via a mobile phone. System obtains data from motion capture elements, analyzes data and stores data in database for use in these applications and/or data mining, which may be charged for. Enables unique displays associated with the user, such as 3D overlays onto images of the user to visually depict the captured motion data. Ratings, compliance, ball flight path data can be calculated and displayed, for example on a map or timeline or both. Enables performance related equipment fitting and purchase. Includes active and passive identifier capabilities.

Abstract: Disclosed are methods, apparatus, systems, and computer readable storage media for trials onboarding. A server may receive a request to generate a trial instance of an organization providing data and functionality for a period of time. Data on the request may also be stored. The trial instance may be selected from a template based on an access channel corresponding to the request.

Abstract: A method and apparatus of percutaneous cochlear implantation (PCI).

Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: The present invention, in another aspect, relates to a microstereotactic table. In one embodiment, the microstereotactic table includes a plate member having a first surface, an opposite, second surface, a body portion defined therebetween, a plurality of leg members, each of them removably engaged with the plate member, respectively, and a passage is formed between the first surface and the opposite, second surface of the body portion of the plate member and along a longitudinal axis, wherein a step is formed within the passage, and wherein the step is formed such that the distance from the step to one of the first surface and the opposite, second surface along the longitudinal axis is a predetermined length.

Abstract: A novel price paid database, method, system, and computer program product in which checkout items are scanned at a plurality of stores, and a checkout computer identifies the purchased items. The checkout computer determines a price paid for each purchased item. A central computer records in a price-paid database an item identification and price-paid for each purchased items. The central computer publishes the price-paid database. The checkout computer recurrently updates the price-paid database in the central computer with the price paid for each purchased item, the customer identification (if available), the store identification, and a list price for each purchased item.

Abstract: A method and a system for contextual recognition through screen-sharing are provided. Example embodiments may include receiving a data stream related to a presenter screen in a network-based collaboration session from a first user; extracting characteristic data from the data stream; associating added data with the data stream, based on the data; and presenting, in real time, to a second user, a viewer screen including the data stream and the added data. The method may also include recognizing the characteristic data before the extracting of the data.

Abstract: Systems and methods for performing computer-assisted procedures are provided. In the systems and methods, a current rigid transformation is applied to a first set of points with respect to a second set of points to obtain a current transformed set of points. Thereafter, a linearized transformation is determined that minimizes a weighted fiducial registration error between the current transformed set and the second set. An updated rigid transformation is then obtained based on the current rigid transformation, the translation vector of the linearized transformation, and a rotation matrix that is closest to the linearized matrix of the linearized transformation, followed by applying the updated rigid transformation to the first set to obtain an updated transformed set of points. Finally, if motion associated with such updating fails to meet some criterion, the determining, obtaining, and applying are iteratively repeated using the updated rigid transformation and the updated transformed set.

Abstract: In one aspect, an apparatus for supporting an adjustable surgical platform is disclosed. In one embodiment, the apparatus includes a supporting platform portion with a body portion that defines bore along a central axis. Arm portions with engaging means extend radially from the supporting platform portion. The apparatus also includes a shaft portion extending from the supporting platform portion in a first direction, with a shaft body portion that defines a bore along a longitudinal axis B. The bore of the shaft body portion is in communication with the bore of the supporting platform portion. The apparatus further includes a base portion connected to the shaft portion, and that defines a bore in communication with the bore of the shaft portion and the bore of the supporting platform portion. Mounting means are configured to secure the base portion to a region of interest of a living subject.

Abstract: Provided is a debris guard disposable in a pool to prevent debris floating on the surface of the water from entering the pool skimmer. The debris guard forms a barrier around the skimmer opening at the water surface to keep debris out of the skimmer to allow water to circulate through the skimmer and the water filter. In this regard, the debris guard does not significantly reduce or inhibit the flow rate of water flowing through the pool filtration system.

Abstract: In one aspect, an apparatus for supporting an adjustable surgical platform is disclosed. In one embodiment, the apparatus includes a supporting platform portion with a body portion that defines bore along a central axis. Arm portions with engaging means extend radially from the supporting platform portion. The apparatus also includes a shaft portion extending from the supporting platform portion in a first direction, with a shaft body portion that defines a bore along a longitudinal axis B. The bore of the shaft body portion is in communication with the bore of the supporting platform portion. The apparatus further includes a base portion connected to the shaft portion, and that defines a bore in communication with the bore of the shaft portion and the bore of the supporting platform portion. Mounting means are configured to secure the base portion to a region of interest of a living subject.

Abstract: A system and methods for providing an access to a cochlea of a living subject. In one embodiment of the present invention, a method comprises the steps of operating a surgical instrument towards a region of interest of the living subject for opening an access to the cochlea of the living subject from the lateral edge of the skull of the living subject to the cochlea of the living subject, and intra-operatively monitoring at least a part of the surgical instrument so that the surgical instrument is operated substantially along a predetermined path.

Abstract: In another aspect, the present invention relates to a method for determining the position and orientation of an anchor attached to the skull of a patient from a topographic image of the anchor acquired therefrom. In one embodiment, the method includes the steps of simulating an image of the anchor that matches the acquired topographic image of the anchor, determining the position and orientation of the anchor from the simulated image of the anchor, and determining the position and orientation of the anchor in the acquired topographic image of the anchor from the position and orientation of the anchor determined from the simulated image of the anchor. The simulating step comprises the step of modeling the anchor with an object that has a geometric shape simpler than that of the anchor.

Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.

Abstract: An apparatus for installing a corner bead to a doorway is provided. The apparatus may comprise a flange and an attachment base which are integrally connected to each other. The attachment base is securable to a doorframe such that upon securement, the flange and the doorframe form a receiving channel for receiving the corner bead therein. Such configuration maintains the structural integrity of the doorframe, maintains the length of the exposed edge of the doorframe and reduces cost to install the corner bead to the doorway.

Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.