Abstract: The present invention relates to polypeptides that are directed against Receptor Activator of Nuclear Factor Kappa B Ligand (RANK-L) also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF). In a preferred embodiment, the polypeptide is an i-body comprising the modified domain 1 of NCAM forming the i-body scaffold, and an antigen-binding domain comprising CDR1 and CDR3 based on shark IgNAR antibody.

Abstract: A dispensing system for filling and refilling user propane tanks comprised of a point of purchase payment system with interactive display. Each purchased propane tank is filled at an access point within the dispensing unit for users to retrieve their order. A secondary payment method involves the use of a mobile app to purchase propane tanks and propane. A docking area takes both new tanks and tanks that need refilling. When refilling a propane tank, the user inserts the propane tank into the docking area. The propane tank is mechanically filled and inspected with cameras for damage and a leak test is conducted returned to the original docking area for the user to retrieve. The final amount on the customer invoice is based on the actual quantity of propane delivered into the user tank. The system also includes an autofill nozzle and autofill valve for application such as RVs.

Abstract: A carousel positioned around a dispensing tank not having a enter hub or physical center axis. Each carousel level has an 11 slot input capacity to receive and store user propane tanks and one open area to allow the robotic picker to pass vertically unobstructed. The carousel rotates clockwise or counterclockwise with the aid of a motorized track mounted next to or under the carousel. Markings along the outer surface of the carousel allow tracking and location. Multiple carousel levels are positioned vertically around the dispensing tank. Carousels ride along castor rails positioned around both inner and outer ridges of carousel. When a stored user propane tank is delivered to a customer, the carousel rotates to an available user propane tank within its available inventory and delivers the user propane tank to a door slide moves user propane tanks to a door users can access.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: Techniques for an ontology-based approach for modeling service dependencies in a provider network. The approach is flexible and extensible to different provider network SOA systems and not limited to a particular provider network or a particular SOA system. The approach can be used to model an entire SOA system or selected portion thereof and from different perspectives. In some examples, the approach uses an ontology represented using a Web Ontology Language (OWL). In some examples, the ontology is used to identify service dependencies and relationships in a knowledge base that is populated based on operational data collected in the provider network environment.

Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: This disclosure relates to an amyloid beta peptide (A?)-oligomer-specific antigen binding molecule and the use thereof as a diagnostic agent or as a therapeutic agent for the treatment or prevention of Alzheimer's Disease, Down's syndrome, mild cognitive impairment, cerebral amyloid angiopathy, vascular dementia, multi-infarct dementia, Parkinson's disease, Dementia with Lewy Bodies, Huntington's disease, Creutzfeldt-Jakob disease, cystic fibrosis, or Gaucher's disease.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: This disclosure relates to an amyloid beta peptide (A?)-oligomer-specific antigen binding molecule and the use thereof as a diagnostic agent or as a therapeutic agent for the treatment or prevention of Alzheimer's Disease, Down's syndrome, mild cognitive impairment, cerebral amyloid angiopathy, vascular dementia, multi-infarct dementia, Parkinson's disease, Dementia with Lewy Bodies, Huntington's disease, Creutzfeldt-Jakob disease, cystic fibrosis, or Gaucher's disease.

Abstract: Disclosed are AMA-1 immunogenic peptides and epitopes, nucleotide sequences encoding the peptides and epitopes, compositions, and vaccines including the peptides and/or epitopes. Antibodies that specifically bind to AMA-1 and the AMA-1 epitopes and immunogenic peptides disclosed herein are also provided. The disclosure provides for expression vectors, host cells, and methods for making the polypeptides and antibodies. Also provided are methods of treatment, prevention, vaccination, and/or immunization of a subject against malaria and the clinical indications associated with malaria.

Abstract: A technology is described for embedding a semantic annotation in operation code. An example method may include creating an executable package file that includes operation code obtained from a source executable package file. The operation code may be analyzed to identify a program element included in the operation code that is associated with a semantic annotation. The semantic annotation may then be inserted into the operation code relative to the program element associated with the semantic annotation. The executable package file may be executed, launching a program, and the semantic annotation may be evaluated during execution of the program to retrieve semantic context obtained from the ontological data referenced by the semantic annotation. The semantic context may be processed, causing execution behavior of the program to be analyzed in relation to the program element included in the operation code.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: A method comprising syncing, by a platform implemented by one or more processors, a plurality of computer files within an existing client data repository on a server to a specified geolocated polygons on a digital mapping interface, wherein the plurality of computer files are at least one of standalone computer files or computer files in a plurality of file directories; utilizing, by the platform, a geolocated polygon and attribute recommendation tool such that multiple embedded engines including (i) file directory and computer file property parsing to generate address or building name query strings to be processed through a machine learning gazetteer system; and (ii) optical character recognition to locate the address or building name query strings, to be processed through the machine learning gazetteer system, and keywords, processed into n-gram data structures to be cross-referenced against multiple internal or external keyword databases; and recommending, by the platform, geolocated polygons and geofile a