Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

Abstract: The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.

Abstract: An aqueous drilling fluid which contains a diquaternary ammonium cation functionalized clay which provides a substantially constant rheological profile, with respect to salinity, when incorporated into well drilling fluids. A clay/organic chemical composition includes: (a) montmorillonite clay and (b) one or more diquaternary ammonium compounds. A further aspect of the invention is a well drilling process which employs a drilling fluid containing the diquaternary ammonium cation functionalized clay described hereafter.

Abstract: A filter housing providing improved cleanliness is provided. In one embodiment, the filter housing includes a body, a cover plate and a clean fluid manifold assembly. The body has a first plenum defined therein which is configured to accommodate multiple filter elements. The clean fluid manifold having a recess and plurality of index tubes. The recess bounds a second plenum, wherein surfaces of the recess have been machined, or otherwise have had surface material removed to provide a smooth, clean and contamination free surface. The plurality of index tubes have a first end coupled to the clean fluid manifold and a second end extending into the first plenum, the second end of the index tube configured to engage with a filter element.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: A diskless host computer is automatically configured upon adding it to storage-area network (SAN). Upon physically connecting the diskless host computer to the network, the host computer alerts the network and a control station of its presence. A suitable identifier provided by the host, such as a Fibre Channel World Wide Name, is used to look up a configuration corresponding to a host of its type. Configurations corresponding to all types of hosts expected to be connected to the network are pre-stored in the SAN data storage system. Each configuration includes an operating system and can include any other software related to configuring or installing a new host. The control station then provides access to a storage device on which the operating system is stored so that the host can boot from it or access it for any other purposes.

Abstract: The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).

Abstract: The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

Abstract: An aqueous drilling fluid which contains a diquaternary ammonium cation functionalized clay which provides a substantially constant rheological profile, with respect to salinity, when incorporated into well drilling fluids. A further aspect of the invention is a well drilling process which employs a drilling fluid containing the diquaternary ammonium cation functionalized clay described hereafter. A clay/organic chemical composition that comprises: (a) montmorillonite clay and (b) one or more diquaternary ammonium compounds.

Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.

Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.