Patents by Inventor Michael Graeber

Michael Graeber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION TREATMENT FOR ROSACEA
    Publication number: 20150313894
    Abstract: The invention relates to a method of treating erythema and/or telangiectasia associated with rosacea in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the site of erythema and/or telangiectasia on the skin of the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: July 13, 2015
    Publication date: November 5, 2015
    Inventors: Michael Graeber, Matthew James Leoni, Nathalie Wagner
  • COMBINATION TREATMENT FOR DERMATOLOGICAL CONDITIONS
    Publication number: 20150313895
    Abstract: The invention relates to a method of treating dermatological conditions or symptoms associated therewith in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the affected area of skin on the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: July 13, 2015
    Publication date: November 5, 2015
    Inventors: Michael Graeber, Matthew James Leoni, Nathalie Wagner
  • METHODS AND COMPOSITIONS FOR SAFE AND EFFECTIVE TREATMENT OF ERYTHEMA
    Publication number: 20150209350
    Abstract: Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.3% to about 10% by weight of brimonidine and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 6, 2015
    Publication date: July 30, 2015
    Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Yin-sang LIU, Matthew James LEONI
  • METHOD FOR PREVENTING OR TREATING SKIN TUMOR
    Publication number: 20150098917
    Abstract: Methods, compositions and products for preventing skin tumor formation or inhibiting the development of an existing skin tumor in a subject are described. The methods involve administering to the subject a composition containing an ?2 adrenergic receptor agonist, such as brimonidine.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Guy BOUVIER, Matthew James LEONI, Michael GRAEBER
  • METHOD FOR THE TREATMENT OF ACNE USING PHARMACEUTICAL COMPOSITIONS COMPRISING 0.3% BY WEIGHT OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID
    Publication number: 20150045440
    Abstract: Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously formulated into topically applicable gels, preferably aqueous gels, creams, lotions or solutions.
    Type: Application
    Filed: October 27, 2014
    Publication date: February 12, 2015
    Inventors: Michael GRAEBER, Janusz CZERNIELEWSKI
  • Method for the treatment of acne using compositions comprising 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid
    Patent number: 8921423
    Abstract: Dermatological disorders having an inflammatory or proliferative component, notably common acne, are treated with topically applicable pharmaceutical compositions containing about 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously formulated into topically applicable gels, preferably aqueous gels, creams, lotions or solutions.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: December 30, 2014
    Assignee: Galderma Research & Development
    Inventors: Michael Graeber, Janusz Czernielewski
  • Methods and compositions for safe and effective treatment of telangiectasia
    Patent number: 8916562
    Abstract: Improved methods and compositions for safe and effective treatment of telangiectasia or a symptom associated with telangiectasia in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.3% to about 10% by weight of brimonidine and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: December 23, 2014
    Assignee: Galderma Research & Development SNC
    Inventors: Michael Graeber, Christian Loesche, Philip Freidenreich, Yin Liu, Matthew James Leoni
  • Method for preventing or treating skin tumor
    Patent number: 8911713
    Abstract: Methods, compositions and products for preventing skin tumor formation or inhibiting development of an existing skin tumor in a subject are described. The methods involve administering to the subject a composition containing an ?2 adrenergic receptor agonist, such brimonidine.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 16, 2014
    Assignee: Galderma Research & Development
    Inventors: Guy Bouvier, Matthew James Leoni, Michael Graeber
  • ADMINISTRATION OF ADAPALENE AND BENZOYL PEROXIDE FOR THE LONG-TERM TREATMENT OF ACNE VULGARIS
    Publication number: 20140336257
    Abstract: A regimen for the safe and effective long-term treatment of acne vulgaris entails topically applying onto the affected skin area of a subject afflicted therewith, for a period of time of at least four (4) months, e.g., for at least twelve (12) months and advantageously on a daily basis and preferably once a day, a thus effective amount of a topical medicament containing adapalene and benzoyl peroxide, formulated into a pharmaceutically acceptable medium therefor.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 13, 2014
    Inventors: Michael GRAEBER, Yin LIU, Barbara GORE
  • ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS
    Publication number: 20140308223
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Application
    Filed: March 21, 2014
    Publication date: October 16, 2014
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Michael GRAEBER, Janusz CZERNIELEWSKI
  • ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS
    Publication number: 20140249232
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Application
    Filed: April 28, 2014
    Publication date: September 4, 2014
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Michael GRAEBER, Janusz CZERNIELEWSKI
  • Administration of adapalene and benzoyl peroxide for the long-term treatment of acne vulgaris
    Patent number: 8809305
    Abstract: A regimen for the safe and effective long-term treatment of acne vulgaris entails topically applying onto the affected skin area of a subject afflicted therewith, for a period of time of at least four (4) months, e.g., for at least twelve (12) months and advantageously on a daily basis and preferably once a day, a thus effective amount of a topical medicament containing adapalene and benzoyl peroxide, formulated into a pharmaceutically acceptable medium therefor.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: August 19, 2014
    Assignee: Galderma Research & Development
    Inventors: Michael Graeber, Yin Liu, Barbara Gore
  • Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
    Patent number: 8729127
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: May 20, 2014
    Assignee: Galderma Research & Development
    Inventors: Michael Graeber, Janusz Czernielewski
  • Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
    Patent number: 8703820
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: April 22, 2014
    Assignee: Galderma Research & Development
    Inventors: Michael Graeber, Janusz Czernielewski
  • COMBINATION TREATMENT FOR ROSACEA
    Publication number: 20140100232
    Abstract: The invention relates to a method of treating erythema and/or telangiectasia associated with rosacea in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the site of erythema and/or telangiectasia on the skin of the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 10, 2014
    Applicant: Galderma Laboratories Inc.
    Inventors: Michael Graeber, Matthew James Leoni, Nathalie Wagner
  • COMBINATION TREATMENT FOR DERMATOLOGICAL CONDITIONS
    Publication number: 20140094470
    Abstract: The invention relates to a method of treating dermatological conditions or symptoms associated therewith in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the affected area of skin on the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 10, 2013
    Publication date: April 3, 2014
    Applicant: Galderma Laboratories Inc.
    Inventors: Michael Graeber, Matthew James Leoni, Nathalie Wagner
  • METHODS AND COMPOSITIONS FOR SAFE AND EFFECTIVE TREATMENT OF ERYTHEMA
    Publication number: 20140094469
    Abstract: Improved methods and compositions for safe and effective treatment of erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical composition comprising about 0.3% to about 10% by weight of brimonidine and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Yin-sang LIU, Matthew James LEONI
  • METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING ERYTHEMA
    Publication number: 20140080836
    Abstract: Methods and products for treating or preventing erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical aqueous gel composition comprising about 0.01% to about 10% by weight of at least one ?-adrenergic receptor agonist and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 19, 2013
    Publication date: March 20, 2014
    Applicant: GALDERMA LABORATORIES INC.
    Inventors: Michael GRAEBER, Christian LOESCHE, Philip FREIDENREICH, Jack A. DEJOVIN, Isabelle Jean DEJOVIN, Yin-sang LIU, Matthew James LEONI
  • Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders
    Patent number: 8653140
    Abstract: Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: February 18, 2014
    Assignee: Galderma Research & Development
    Inventors: Michael Graeber, Janusz Czernielewski
  • Methods and compositions for treating or preventing erythema
    Patent number: 8586586
    Abstract: Methods and products for treating or preventing erythema or a symptom associated with erythema in a subject are described. The methods involve topically applying to an affected skin area a topical aqueous gel composition comprising about 0.01% to about 10% by weight of at least one ?-adrenergic receptor agonist and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 19, 2013
    Assignee: Galderma Laboratories Inc.
    Inventors: Michael Graeber, Christian Loesche, Philip Freidenreich, Jack A. DeJovin, Isabelle Jean DeJovin, Yin-sang Liu, Matthew James Leoni