Abstract: Aerosol generator having a liquid reservoir (10) defining in a sealed state a volume VR configured to hold an initial volume of liquid VL; a membrane (5) having openings, the liquid reservoir (10) being connected to the membrane (5) to feed the liquid to one side of the membrane, the membrane being oscillatable to transport the liquid through the openings whereby the liquid is emitted in the form of an aerosol on the other side of the membrane, wherein the volume VR of the liquid reservoir (10) before the membrane (5) is oscillated is configured to contain more than 5 ml of gas at an initial volume of the liquid VL of at least 5 ml.

Abstract: The present application relates to novel substituted 8-alkoxy-2-aminotetraline derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

Abstract: A lock for securing a bipod against theft, which may include a base, and first and second locking members each connected to the base. The first and second locking members are shaped and designed to lock one or more of the following parts of the bipod to a rigid object: a front wheel, a rear wheel, and a frame. In a preferred embodiment, the locking members include elongated loops, such as elongated arch-shaped members, which are preferably nestable for ease of transportation and storage, and whose distal ends may be removably connected to the base. One or more of the distal ends of the locking members may be permanently attached to the base, so that the locking mechanism may be transported and stored as a single unit. The locking members can preferably pivot relative to the base.

Abstract: A flow shifting fuel cell with water separator. The water separator is used to control the amount of moisture that passes through the anode flowpath of one or more fuel cells in one or more fuel cell stacks. The water separator is made up of a housing to direct the flow of a moisture-bearing fluid as well as act as a collection and container for separated moisture. Fluid that is cyclically passing through the fuel cell stack as part of its flow shifting mode of operation oscillates back and forth across a separation chamber formed within the water separator, thereby allowing bidirectional control of the moisture content within the fluid. A drain is formed in the separation chamber to allow removal of condensed water.

Abstract: The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel cyclopropylacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

Abstract: A joint arrangement, for a vehicle, is provided with a joint (7), which has a joint housing (8) and a pivot pin (9) mounted movably in relation thereto. The arrangement also includes a rod (4), which has a cavity (6) and is connected to the joint (7); a sealing bellows (10), which defines an interior space (10) and in which the joint (7) is arranged at least partially; and a gas-permeable connection (13), which connects the cavity (6) of the rod (4) to the interior space (11) of the sealing bellows (10) and has at least one groove (15), which is formed in a front side (21) of the joint (7), which said front side faces the rod (4), opens into the interior space (11) and has a radially outer end (27). The groove (15) with its radially outer end ends at a spaced location from the outer circumferential contour of the front surface (21).

Abstract: The present application relates to novel alkylcarboxylic acids having an oxo-substituted azaheterocyclic partial structure, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: The invention relates to methods for identifying genes involved in TRAIL-induced apoptosis, to inhibitors of the expression of genes inducing resistance of cells to TRAIL-induced apoptosis and to activators of the expression of a gene sensitizing cells to TRAIL-induced apoptosis. The invention also relates to methods for sensitizing cells to TRAIL-induced apoptosis, methods for treating hyperproliferative diseases, methods for determining the responsiveness of a subject suffering from a hyperproliferative disease to TRAIL, to pharmaceutical compositions comprising products capable of sensitizing cells to TRAIL-induced apoptosis, and to methods for determining the prognosis of a subject suffering from a hyperproliferative disease.

Abstract: The invention relates to biphenyl compounds of formula (I): wherein U, V and W together form a group of the formula *—CH?CH—CH<, *—CH2—CH2—CH< or *—CH2—CH2—N<, in which * means the point of linkage to the phenyl ring; A is O or CH2; and D, E, X, Y, Z, R1, R2, o, n, and p are as defined in the specification. The invention also relates to pharmaceutical compositions of the compound of the compounds. The compounds and pharmaceutical compositions of the invention can be used in the treatment or prevention of cardiovascular disorders.

Abstract: The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.

Abstract: The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

Abstract: An electrical contact device for an arrangement includes two apparatuses, between which a relative movement takes place along a first movement path. In at least one embodiment, the electrical contact device includes a first contact, including a first contact surface, and includes a second contact including a first multiplicity of contact arms, each provided with a contact projection for making contact with the first contact surface. In at least one embodiment, in order to prevent excessive friction wear to the first contacts even when the contact projections of the associated second contacts are arranged successively in the same direction as the first movement path, at least one device is provided for controlling a relative movement between the two contacts along a second movement path, which runs parallel to the first contact surface of the first contact and obliquely with respect to the first movement path.

Abstract: The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Abstract: An electrical contact device for an arrangement includes two apparatuses, between which a relative movement takes place along a first movement path. In at least one embodiment, the electrical contact device includes a first contact, including a first contact surface, and includes a second contact including a first multiplicity of contact arms, each provided with a contact projection for making contact with the first contact surface. In at least one embodiment, in order to prevent excessive friction wear to the first contacts even when the contact projections of the associated second contacts are arranged successively in the same direction as the first movement path, at least one device is provided for controlling a relative movement between the two contacts along a second movement path, which runs parallel to the first contact surface of the first contact and obliquely with respect to the first movement path.

Abstract: A joint arrangement, for a vehicle, is provided with a joint (7), which has a joint housing (8) and a pivot pin (9) mounted movably in relation thereto. The arrangement also includes a rod (4), which has a cavity (6) and is connected to the joint (7); a sealing bellows (10), which defines an interior space (10) and in which the joint (7) is arranged at least partially; and a gas-permeable connection (13), which connects the cavity (6) of the rod (4) to the interior space (11) of the sealing bellows (10) and has at least one groove (15), which is formed in a front side (21) of the joint (7), which said front side faces the rod (4), opens into the interior space (11) and has a radially outer end (27). The groove (15) with its radially outer end ends at a spaced location from the outer circumferential contour of the front surface (21).

Abstract: The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.