Abstract: The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.

Abstract: The present invention relates to a combination of selective blockers of TASK-1 and TASK-3 channels, in particular diazabicyclically substituted imidazo [1,2-a]pyrimidine derivatives and ?2-Adrenoceptor subtype C (alpha-2C) antagonists, in particular arylquinolizine derivatives of formula (I) for the treatment and/or prophylaxis of sleep-related breathing disorders, preferably obstructive and central sleep apneas and snoring.

Abstract: The present invention relates to a combination of selective blockers of TASK-1 and TASK-3 channels, in particular diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives and ?2-Adrenoceptor subtype C (alpha-2C) antagonists, in particular aryl piperazines of formula (I) for the treatment and/or prophylaxis of sleep-related breathing disorders, preferably obstructive and central sleep apneas and snoring.

Abstract: The present invention relates to ?2-Adrenoceptor subtype C (alpha-2C) antagonists, in particular arylquinolizine derivatives of formula (I) for the use in a method for the treatment and/or prophylaxis of sleep-related breathing disorders, preferably obstructive and central sleep apneas and snoring.

Abstract: A glass article is composed of an aluminosilicate glass with at least one halogen with refining action in an amount ranging from 500 ppm to 8000 ppm and an Sn content of less than 500 ppm. The glass has less than 100 ppm As and less than 100 ppm Sb and the glass article has a thickness of less than 250 ?m.

Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.

Abstract: The invention relates to an assembly (100) of a strip for connecting a leaf to a frame in an articulated manner about a hinge axis (S), comprising an installation part (10) which can be installed on an installation side of the leaf or the frame, a strip tab (20) which can be secured to the installation part (10), and a first adjustment means (50), by means of which the strip tab (20) can be pivoted relative to the installation part (10) in an adjustment range (J) about a pivot axis (B) extending parallel to the hinge axis (S), wherein, of the installation part (10) and the strip tab (20), one has a securing groove (31) with a groove opening (32) and a groove longitudinal axis (A), which extends parallel to the hinge axis (S), and the other of the installation part (10) and the strip tab (20) has a securing protrusion (35) which engages into the securing groove (31).

Abstract: Snippets of content associated with a communication platform are described. In an example, based at least in part on a determination, by the communication platform, that a user of the communication platform is permitted to access one or more snippets of content provided by one or more other users of the communication platform, causing one or more user interface elements associated with the one or more snippets of content to be presented via a user interface of a user computing device of the user. The communication platform can receive, from the user computing device, a request to view a snippet of content of the one or more snippets of content and can cause the snippet of content to be presented by the user computing device via the user interface associated with the communication platform.

Abstract: An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane having a first side for being in contact with the fluid and an opposite second side, the membrane having a plurality of through holes penetrating the membrane in an extension direction from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having along its extension direction a smallest diameter, a larger diameter that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, wherein the ratio of the total length of each through hole in the extension di

Abstract: Various embodiments are directed to apparatuses, systems, and methods for authorizing within a group-based communication interface a bundled plurality of applications to be collectively installed in a group-based communication workspace enabling communications between client devices via a group-based communication system. Various embodiments are directed to apparatuses, systems, and methods for collectively installing within a group-based communication system a bundled plurality of applications associated with an application bundle. Various embodiments are directed to apparatuses, systems, and methods for generating within a group-based communication interface application bundle data associated with a plurality of applications.

Abstract: A board associated with a communication platform and/or one or more channels associated therewith is described. In an example, the board can be associated with editable text and one or more objects capable of being at least one of reordered, added, deleted, or edited. In an example, the one or more objects can be associated with one or more sections. In an example, a communication platform can perform a modification to the board, based at least in part on receiving a request associated with the modification, and can cause the board to be presented via a user interface associated with a member of at least one communication channel with which the board is associated. In an example, the board can be sharable with users associated with different communication channels, workspaces, organizations, or the like.

Abstract: Various examples are directed to systems, methods, and apparatuses for providing an interactive developer interface of a group-based communication system. Various examples are directed to systems, methods, and apparatuses for consolidating application data associated with an application within a group-based communication interface. Various examples are directed to systems, methods, and apparatuses for indexing processing actions associated with a plurality of applications.

Abstract: Systems and methods provide managing of communication between a remote data object hosted by a remote resource and a group-based communication interface of a group-based communication system.

Abstract: (alpha-2C) antagonists, in particular substituted piperidinyl-pyrimidinyl-tetra hydrochinolines and piperidinyl-pyridinyl-tetrahydrochinolines of formula (I) for the use in a method for the treatment and/or prophylaxis of sleep-related breathing disorders, preferably obstructive and central sleep apneas and snoring. Formula (I) in which X is a group (A) or (B).

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: A ball joint, in particular a chassis joint, which has a housing and a ball socket that comprises a ball bearing section for receiving a joint ball. An anti-rotation member prevents movement of the ball socket within the housing. To improve operational performance of the ball joint, the anti-rotation member is formed by a connecting element of the housing and a mating connecting element of the ball socket. The connecting elements have corresponding holding profiles so that, in an assembled condition, the connecting elements form a shape-enclosing plug-in connection.

Abstract: Embodiments of the present disclosure provide methods, systems, apparatuses, and computer program products for building and rendering a message user interface (UI) within a group-based communication interface of a group-based communication system, where the message UI is rendered to a client device based on a customizable block configuration and on customizable block data that is received from an external application.

Abstract: The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.

Abstract: Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Abstract: Snippets of content associated with a communication platform are described. In an example, based at least in part on a determination, by the communication platform, that a user of the communication platform is permitted to access one or more snippets of content provided by one or more other users of the communication platform, causing one or more user interface elements associated with the one or more snippets of content to be presented via a user interface of a user computing device of the user. The communication platform can receive, from the user computing device, a request to view a snippet of content of the one or more snippets of content and can cause the snippet of content to be presented by the user computing device via the user interface associated with the communication platform.