Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

Abstract: The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.

Abstract: A patch and compositions for iontophoresis of triptan compounds are described.

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract: A patch and compositions for iontophoresis of triptan compounds are described.

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

Abstract: The invention relates to a transdermal therapeutic system (TTS) which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system incorporates a back layer and an active substance-containing layer that includes at least one peptide and a carrier substance.

Abstract: The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.

Abstract: The present invention relates to adhesive bandages provided with a water-vapor permeable back layer and an adhesive layer, in which the adhesive layer includes 10 weight percent of a disperse internal phase of hydrophilic particles that are water-swellable in an outer phase that includes at least 10 weight percent of a styrene block copolymer and at least 20 weight percent of an ester gum of the colophony, and that can further contain at least one anti-virus substance.

Abstract: The invention relates to transdermal therapeutic systems (TTS) which include, as active ingredient, the NMDA receptor antagonist memantine or one of its physiologically compatible salts. The TTSs can be produced and used for treating diseases of the central nervous system.

Abstract: A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided.

Abstract: Transdermal therapeutic system with which at least one pharmaceutical active substance that is non-volatile at room temperature can be administered at a daily dose of at most 30 mg, comprising a rear surface directed away from the skin and impermeable to the active substance, an adjoining polymer layer located away from the skin and based on polyisobutylene with a coating weight of at least 80 g/m2, an adhesive skin contact layer resting on the skin-remote polymer layer and based on acrylate copolymers with a coating weight of at most 50 g/m2, and a protective layer that is impermeable to the active substance and can be peeled off from the skin contact layer.

Abstract: The invention relates to a method for improving the permeability of the human skin in order to transdermally supply active substances, permeability being improved by means of a plaster that is transparent in at least some areas, contains active substance, and is flexible in at least some areas, and at least one external light source. According to said method, light that is emitted at least for a short period of time by an external light source and normally impinges at least some areas of the plaster is focused onto the stratum corneum of the skin with the aid of a plurality of individual focusing lenses which are integrated into the plaster so as to bring about changes in the stratum corneum, said changes improving the permeability of the skin. The inventive method for improving the permeability of the human skin allows for reproducible permeability for specific active substances.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for administering pharmaceutical agents through the skin, comprising a back layer (R) impermeable to the agent and at least one layer (S) comprising the agent, wherein the layer (H) facing the skin comprises urea in solid form, allowing continuous administration of large quantities of agent over a long period of time.

Abstract: The present invention relates to a transdermal therapeutic system comprising at least one readily volatile and/or thermolabile active ingredient and/or auxiliary, which can be produced by laminating at least three components onto one another, namely a polymeric matrix layer, a likewise polymeric acceptor layer that absorbs the active ingredient and/or auxiliary at an increased rate, and a donor layer comprising, at the point of production, the volatile and/or thermolabile active ingredient and/or auxiliary. The system according to the invention is characterized in that, during or shortly after the lamination process, the donor layer combines with the acceptor layer as a result of migration of the readily volatile and/or thermolabile substances.

Abstract: The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and is characterized by a considerably increased utilization of the active substance.

Abstract: The invention relates to a transdermal therapeutic system which comprises a back layer that is impermeable to the active substance, and a peelable protective layer that is impermeable to the active substance and at least one matrix layer consisting of polysiloxanes and/or polysiloxane derivatives and containing micro-reservoirs. Said micro-reservoirs contain at least one ion pair from a pharmacologically active substance and an additive and either the active substance is nucleophilic and the additive is electrophilic or the active substance is electrophilic and the additive is nucleophilic.

Abstract: The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.

Abstract: Disclosed is a monitoring system for collecting and/or transdermally rediffusing air containing environmental contaminants. The inventive monitoring system generally includes at least one diffusion collector and/or an equilibrium diffuser. The diffusion collector is provided with at least three layers, i.e. an adhesive layer that is in direct contact with the skin of a living being, a barrier layer, and a collecting layer on the exterior face of the monitoring system. The equilibrium diffuser includes an adhesive layer and a collecting layer. The collecting layers and the adhesive layers of the two components of the monitoring system are preferably made of the same material and have the same dimensions.