Abstract: A patch and compositions for iontophoresis of triptan compounds are described.

Abstract: The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

Abstract: The invention relates to a transdermal therapeutic system (10) comprising a pharmaceutical active agent formulation (13), an adhesive layer (11) comprising a contact surface (12), and at least one ultrasound transmitter (21), the side of the ultrasound transmitter opposing the contact surface being directly or indirectly adjacent to the pharmaceutical active agent formulation. The transdermal therapeutic system is a multi-layered laminate, one of the laminate layers comprising the ultrasound transmitter, another comprising the adhesive layer, and another comprising the pharmaceutical active agent formulation. Furthermore, from a top view, at least in a plane position of the transdermal therapeutic system, all of the laminate layers (11, 21, 14) are at least approximately mutually congruent and are at least approximately the size of the contact surface.

Abstract: A transdermal therapeutic system consisting of a backing layer, at least one active substance-containing matrix layer, which may at the same time possess pressure-sensitive adhesive properties, as well as a removable protective layer is characterized by a content of a neuroleptic, a content of at least one permeation enhancer as well as by a layer which is pressure-sensitive adhesive on the skin-facing side and based on polymers which are pure hydrocarbons.

Abstract: A containment bracket is disclosed for encasing a cable or wire within an enclosure designed to house electrical components. The containment bracket includes a housing having an interior region, the housing being attached to the enclosure. The containment bracket further includes a door coupled to the housing to access the interior region of the housing. A method for encasing a cable or wire within an enclosure designed to house electrical components is further disclosed.

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract: Disclosed is a monitoring system for collecting and/or transdermally rediffusing air containing environmental contaminants. The inventive monitoring system generally includes at least one diffusion collector and/or an equilibrium diffuser. The diffusion collector is provided with at least three layers, i.e. an adhesive layer that is in direct contact with the skin of a living being, a barrier layer, and a collecting layer on the exterior face of the monitoring system. The equilibrium diffuser includes an adhesive layer and a collecting layer. The collecting layers and the adhesive layers of the two components of the monitoring system are preferably made of the same material and have the same dimensions.

Abstract: A device for transdermal administration of active substances, comprising a backing layer and an active substance-containing reservoir connected to the backing layer. The skin-facing contact surface of the device has a plurality of microprotrusions which are suitable for penetrating the skin and which are equipped with structures that make extracting the protrusions from the skin more difficult.

Abstract: A device for the administration of basic active agents, such as nicotine, to the human or animal body. The active agents are administered by inhalation. The device comprises a first preparation containing a nicotine base or/and a further basic active agent and, a second or further preparations. At least one preparation contains at least one volatile acid suitable for inhalation.

Abstract: A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

Abstract: Transdermal pharmaceutical preparations for the treatment of Parkinson's disease containing a combination of at least two active substances selected from the following groups of active substances: dopamine agonists and L-dopa, monoamine oxidase inhibitors, anticholinergics, NMDA-receptor antagonists, sympathomimetics; at least two of the said active substances being members of different active substance groups.

Abstract: The invention relates to a method for improving the permeability of the human skin in order to transdermally supply active substances, permeability being improved by means of a plaster that is transparent in at least some areas, contains active sub-stance, and is flexible in at least some areas, and at least one external light source. According to said method, light that is emitted at least for a short period of time by an external light source and normally impinges at least some areas of the plaster is focused onto the stratum corneum of the skin with the aid of a plurality of individual focusing lenses which are integrated into the plaster so as to bring about changes in the stratum corneum, said changes improving the permeability of the skin. The inventive method for improving the permeability of the human skin allows for reproducible permeability for specific active substances.

Abstract: The invention relates to a method for producing self-solidifying film forming substances from initial liquid substances in a device designed for this purpose and to a corresponding device. The inventive method consists in coating an inert continuously advancing carrier in the form of the part of said device with initial substances (7, 13). A dosing device (25) makes it possible to adjust the thickness of said initial substances for coating the carrier. The coated carrier conveys a substance layer (23) to a drying device (30). The dried substance layer separates itself from the carrier or is removed therefrom. Said method makes it possible to produce self-solidifying film-forming gelatinous substances exhibiting a low material thickness variation from initial liquid substances.

Abstract: The invention relates to devices for administering heat pulses to the skin, and for heat pulse-promoted transdermal administration of active substances, said device having one or more electric heating elements and a source of current as well as a control unit, the said control unit being suitable for causing a pulse-like heating of the said heating element.

Abstract: A process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate is characterized in that the drying takes place in a first drying stage at between 30 and 50° C., in a second drying stage at between 35 and 80° C., and in third drying stage at between 25 and 50° C.

Abstract: A method for producing individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains:

Abstract: A process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate is characterized in that the drying takes place in a first drying stage at between 30 and 50° C., in a second drying stage at between 35 and 80° C., and in third drying stage at between 25 and 50° C.

Abstract: A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

Abstract: Individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w) of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.

Abstract: A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.